2007 Fiscal Year Final Research Report Summary
Novel Regeneration System based on Fat Producing Adipokine
| Project/Area Number |
18591023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Osaka University |
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Principal Investigator |
MAEDA Kazuhisa Osaka University, Graduate School of Medicine, Assistant Professor (60397750)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIDA Kouji Tohoku University, Graduate School of Medicine, Professor (40244610)
NAKAGAMI Hironori Osaka Univetsty, Graduate School of Medicine, Assistant Professor (20325369)
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| Project Period (FY) |
2006 – 2007
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| Keywords | adipokine / transplantation / feeder cell |
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| Research Abstract |
1. Adipose tissue-derived cells (ADSC) demonstrated potential as angiogenic cell therapy for ischemic disease in mice, which appears to be mainly achieved by their ability to secrete angiogenic growth factors.
2. A novel human feeder cell layer of mesenchymal stem cells harvested from human adipose tissues was established. Transplantation of completely autologous tissue-engineered corneal epithelial cell sheets with healthy donor adipose derived stromal beds were done under the approval by the institutional review board of Osaka University Medical School.
3. Effects of cultured adipose tissue-derived stromal cells on proliferation and differentiation of hematopoietic stem cell was examined. URB (Up-Regulated Bombesin receptor subtype3 knock out mouse) was shown to be abundantly expressed in ADSC and act as a novel adipokine.
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[Journal Article] URB is abundantly expressed in adipose tissue and dysregulated in obesity2008
Author(s)
Okada, T, Nishizawa, H, Kurata, A, Tamba, S, Sonoda, M, Yasui, A, Kuroda, Y, Hibuse, T, Maeda, N, Kihara, S, Hadama, T, Tobita, K, Akamatsu, S, Maeda, K, Shimomura, I, Funahashi, T
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Journal Title
Biochem Biophys Res Commun 367(2)
Pages: 370-376
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Adipose tissue-derived stromal cells as a novel option for regenerative cell therapy2006
Author(s)
Nakagami, H, Morishita, R, Maeda, K, Kikuchi, Y, Ogihara, T, Kaneda, Y
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Journal Title
J Atheroscler Thromb 13(2)
Pages: 77-81
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 肥満と発ガン2007
Author(s)
前田和久
Organizer
第33回日本泌尿器疾患予防医学研究会
Place of Presentation
大阪
Year and Date
2007-07-13
Description
「研究成果報告書概要(和文)」より
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