2007 Fiscal Year Final Research Report Summary
Disruption of circadian rhythm aggravates experimental arthritis: study in cry gene-knockout mice.
| Project/Area Number |
18591110
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
膠原病・アレルギー・感染症内科学
|
|---|
| Research Institution | Kobe University |
|---|
Principal Investigator |
HASHIRAMOTO Akira Kobe University, FES School of Medicine, Associate Professor (80346246)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIURA Yasushi Kobe University, FHS School fo Medicine, Associate Professor (60346244)
|
|---|
| Project Period (FY) |
2006 – 2007
|
| Keywords | circadian rhythum / Cry gene / rheumatoid arthritis / TNF-a |
|---|
| Research Abstract |
Mammalian clock genes, Per and Cry, physiologically regulate circadian rhythm. We show that experimental arthritis in mice impairs rhythmic expression of Per and Cry, and deletion of Cry further aggravates arthritis to maximal levels. While Wee-1 kinase and c-Fos/ AP-1, a transactivator of Wee-1, are up-regulated in human rheumatoid arthritis (RA), and Wee-1 is the sole molecule up-regulated among cell cycle regulators in Cry-1/2 deficient mice, the splenic T cells of Cry-1/2 deficient mice were activated, and the molecules playing essential roles in arthritis such as c-Fos/AP-1, Wee-1, inflammatory cytokines including TNF-a, IL-lb and IL-6, and matrix-degrading MMP-3 were all increased. In particular, Cry transactivated pro-inflammatory cytokine TNF-a. Thus, biological clock modulates human health and disease, in particular, arthritis
|
Research Products
(31 results)
-
-
[Journal Article] Easy and Accurate Diagnosis of Rheumatoid Arthritis Using Anti-Cyclic Citrullinated Peptide 2 Antibody, Swollen Joint Count, and C-Reactive Protein/Rheumatoid Factor2008
Author(s)
Yamane, T, Hashiramoto, A, Tanaka, Y, Tsumiyama, K, Miura, Y, Shiozawa, K, Chihara, K, Shiozawa, S
-
Journal Title
J Rheumatol 35(3)
Pages: 414-420
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and phosphatidylinositol 3-kinase/Akt.2007
Author(s)
Hashiramoto A, Sakai C, Yoshida K, Tsumiyama K, Miura Y, Shiozawa K, Nose M, Komai K, Shiozawa S.
-
Journal Title
Arthritis Rheum. 56
Pages: 2170-2179
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
-
[Journal Article] Decoy receptor 3 expressed in rheumatoid synovial fibroblasts protects the cells against fas-induced apoptosis2007
Author(s)
Hayashi, S, Miura, Y, Nishiyama, T, Mitani, M, Tateishi, K, Sakai, Y, Hashiramoto, A, Kurosaka, M, Shiozawa, S, Doita, M
-
Journal Title
Arthritis Rheum 56(4)
Pages: 1067-1075
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and phosphatidylinositol3-kinase/Akt2007
Author(s)
Hashiramoto, A, Sakai, C, Yoshida, K, Tsumiyama, K, Miura, Y, Shiozawa, K, Nose, M, Komai, K, Shiozawa, S
-
Journal Title
Arthritis Rheum 56(7)
Pages: 2170-2179
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells.2006
Author(s)
Takami N, Osawa K, Miura Y, Komai K, Taniguchi M, Shiraishi M, Sato K, Iguchi T, Shiozawa K, Hashiramoto A, Shiozawa S.
-
Journal Title
Arthritis Rheum. 54
Pages: 779-87
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
[Journal Article] Anchorage on fibronectin via VIA-5(a5b1 integrin)protects rheumatoid synovialcells from Fas-induced apoptosis2006
Author(s)
Kitagawa, A, Miura, Y, Saura, R, Mitani, M, Ishikawa, H, Hashiramoto, A, Yoshiya, S, Shiozawa, S, Kurosakam M
-
Journal Title
Ann Rheum Dis 65(6)
Pages: 721-7
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells2006
Author(s)
Takami, N, Osawa, K, Miura, Y, Komai, K, Taniguchi, M, Shiraishi, M, Sato, K, Iguchi, T, Shiozawa, K, Hashiramoto, A, Shiozawa, S
-
Journal Title
Arthritis Rheum 54(3)
Pages: 779-87
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
-
[Presentation] Disruption of circadian rhythm aggravates experimental arthritis: study in cry gene-knockout mice2006
Author(s)
Yamane, T, Hashiramoto, A, Tsumiyama, K, Okamum, H, Shiozawa, S
Organizer
American College of Rheumatology 70th Annual Scientific Meeting
Place of Presentation
Washington, DC
Year and Date
20061110-15
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
-
-
[Presentation] Anti-CCP2 assay accurately predicts future development of rheumatoid arthritis as early as 3 months from onset of arthritic symptoms
Author(s)
Yamane, T, Shiozawa, K, Hashiramoto, A, Tanaka, Y, Tsumiyama, K, Miura, Y, Shiozawa, S
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] A novel small molecule AP-1 inhibitor T-5224 resolves mouse type II collagen-induced arthritis in a c-Fos/AP-1-specific fashion
Author(s)
Aikawa, Y, Morimoto, K, Yamamoto, T, Chaki, H, Hashiramoto, A, Narita, H, Hirono, S, Shiozawa, S
Description
「研究成果報告書概要(欧文)」より
-
-
[Presentation] Therapeutic efficacy of a novel small molecule AP-1 inhibitor T-5224 on collagen-induced arthritis in mice: characterization of anti-arthritic effect directly inhibiting IL-1.6 and matrix degrading MMPs
Author(s)
Morimoto, K, Aikawa, Y, Yamamoto, T,Chaki, H, Hshiramoto, A, Narita, H, Hirono, S, Shiozawa, S
Description
「研究成果報告書概要(欧文)」より
