2008 Fiscal Year Final Research Report
Analysis of tyrosine kinase genes in childhood leukemia
Project/Area Number |
18591209
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Gunma Institute of Public Health and Environmental Sciences |
Principal Investigator |
SOTOMATSU Manabu Gunma Institute of Public Health and Environmental Sciences, 研究企画係, 研究員 (70251113)
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Co-Investigator(Kenkyū-buntansha) |
HAYASHI Yasuhide 群馬県衛生環境研究所, 研究企画係, 研究員 (30238133)
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Co-Investigator(Renkei-kenkyūsha) |
KATO Masahiko 群馬県衛生環境研究所, 研究企画係, 研究員 (30292593)
MARUYAMA Kenichi 群馬県衛生環境研究所, 研究企画係, 研究員 (70229615)
KUROIWA Minoru 群馬県衛生環境研究所, 研究企画係, 研究員 (90234583)
|
Project Period (FY) |
2006 – 2008
|
Keywords | 小児血液学 |
Research Abstract |
変異は重要な予後因子であった。MLL-PTDは11トリソミーや正常核型で多くみられ、小児でも予後不良であった。Nucleophosmin遺伝子の変異は成人では予後良好であるが、我々の検討では検出されず、小児例はまれと思われた。WTl遺伝子の異常は小児のAMLでは約8%にみられ、予後不良因子と思われた。小児AMLはこれらの遺伝子異常により予後が予測されると思われる。
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Research Products
(139 results)
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[Journal Article] FBXW7 and NOTCH1 mutations in childhood T cel1 acute lymphoblastic leukaemia and T cel1 non-Hodgkin lymphoma2009
Author(s)
Park MJ, Taki T, Oda M, Watanabe T, Yumura-Yagi K, Kobayash, R, Suzuki N,Hara J, Horibe K, Hayashi Y.
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Journal Title
Brit J of Haematol 145
Pages: 198-206
Peer Reviewed
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[Journal Article] A complex t(1;22;11) (q44;q13;q23) translocation causing MLL-p300 fusion gene in therapy-related acute myeloid leukemia.2008
Author(s)
Ohnishi H, Taki T, Yoshino H, Takita J, Ida K, Ishii M, Nishida K, Hayashi Y, Taniwaki M, Bessho F, Watanabe T.
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Journal Title
Eur J Haematol 81
Pages: 475-480
Peer Reviewed
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[Journal Article] C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene.2008
Author(s)
Matsushita H, Nakajima H, Nakamura Y, Tsukamoto H, Tanaka Y, Jin G, Yabe M, Asai S, Ono R. Nosaka T, Sugita K, Morimoto A, Hayashi Y, Hotta T, Ando K, Miyachi H.
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Journal Title
Oncogene 27
Pages: 6749-6760
Peer Reviewed
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[Journal Article] Oncogenic mutations of ALK kinase in neuroblastoma.2008
Author(s)
Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, Wang L, Soda M, Kikuchi A, Igarashi T, Nakagawara A, Hayashi Y, Mano H, Ogawa S.
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Journal Title
Nature 455
Pages: 971-974
Peer Reviewed
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[Journal Article] Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity.2008
Author(s)
Sawada T, Nishiyama C, Kishi T, Sasazuki T, Komazawa-Sakon S, Xue X, Piao JH, Ogata H, Nakayama J, Taki T, Hayashi Y, Watanabe M, Yagita H, Okumura K, Nakano H.
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Journal Title
J Biol Chem. 283
Pages: 26820-8
Peer Reviewed
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[Journal Article] Significance of the complete clearance of peripheral blasts after 7 days of prednisolone treatment in children with acute lymphoblastic leukemia : the Tokyo Children's Cancer Study Group Study L99-15.2008
Author(s)
Manabe A, Ohara A, Hasegawa D, Koh K, Saito T, Kiyokawa N, Kikuchi A, Takahashi H, Ikuta K, Hayashi Y, Hanada R, Tsuchida M.
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Journal Title
Haematologica 93
Pages: 1155-60
Peer Reviewed
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[Journal Article] Whole genome profiling of chromosomal aberrations in hepatoblastoma using high-density single nucleotide polymorphism genotyping microarrays2008
Author(s)
Suzuki M, Kato M, Chen Y, Takita J, Sanada M, Nannya Y, Yamamoto G, Takahashi A, Ikeda H, Kuwano H, Ogawa S, Hayashi Y.
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Journal Title
Cancer Science 99
Pages: 564-570
Peer Reviewed
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[Journal Article] Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNA.2008
Author(s)
Chinen Y, Taki T, Nishida K, Shimizu D, Okuda T, Yoshida N, Kobayashi C, Koike, K, Tsuchida M, Hayashi Y, Taniwaki M.
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Journal Title
Oncogene 27
Pages: 2249-2256
Peer Reviewed
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[Journal Article] Clinical features and outcome of MLL gene rearranged acute lymphoblastic leukemia in infants with additional chromosomal abnormalities other than 11 q23 translocation.2008
Author(s)
Tauchi H, Tomizawa D, Eguchi M, Eguchi-Ishimae M, Koh K, Hirayama M, Miyamura N, Kinukawa N, Hayashi Y, Horibe K, Ishii E.
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Journal Title
Leuk Res. 32
Pages: 1523-1529
Peer Reviewed
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[Journal Article] Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.2008
Author(s)
Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T.
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Journal Title
Genes Dev. 22
Pages: 986-991
Peer Reviewed
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[Journal Article] Mutation and expression analyses of the MET and CDKN2A genes in rhabdomyosarcoma with emphasis on MET overexpression.2007
Author(s)
Chen Y, Takita J, Mizuguchi M, Tanaka K, Ida K, Koh K, Igarashi T, Hanada R, Tanaka Y, Park MJ, Hayashi Y.
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Journal Title
Genes Chromosomes Cancer 46
Pages: 348-358
Peer Reviewed
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[Journal Article] Fms-like tyrosine kinase 3 ligand stimulation induces MLL-rearranged leukemia cells into quiescence resistant to antileukemic agents.2007
Author(s)
Furuichi Y, Goi K, Inukai T, Sato H, Nemoto A, Takahashi K, Akahane K, Hirose K, Honna H, Kuroda I, Zhang X, Kagami K, Hayashi Y, Harigaya K, Nakazawa S, Sugita K.
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Journal Title
Cancer Res. 67
Pages: 9852-9861
Peer Reviewed
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[Journal Article] Outcome of risk-based therapy for infant acute lymphoblastic leukemia with or without an MLL gene rearrangement, with emphasis on late effects : a final report of two consecutive studies, MLL96 and MLL98, of the Japan Infant Leukemia Study Group.2007
Author(s)
Tomizawa D, Koh K, Sato T, Kinukawa N, Morimoto A, Isoyama K, Kosaka Y, Oda T, Oda M, Hayashi Y, Eguchi M, Horibe K, Nakahata T, Mizutani S, Ishii E.
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Journal Title
Leukemia 21
Pages: 2258-2263
Peer Reviewed
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[Journal Article] Omenn syndrome-review of several phenotypes of Omenn syndrome and RAG1/RAG2 mutations in Japan.2006
Author(s)
Kato M, Kimura H, Seki M, Shimada, A, Hayashi Y, Morio T, Kumaki S, Ishida Y, Kamachi Y, Yachie A.
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Journal Title
Allergol Int. 55
Pages: 115-119
Peer Reviewed
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[Journal Article] Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies.2006
Author(s)
Chen Y, Takita J, Hiwatari M, Igarashi T, Hanada R, Kikuchi A, Hongo T, Taki T, Ogasawara M, Shimada A, Hayashi Y.
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Journal Title
Genes Chromosomes Cancer 45
Pages: 583-591
Peer Reviewed
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[Journal Article] KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study Group.2006
Author(s)
Shimada A, Taki T, Tabuchi K, Tawa A, Horibe K, Tsuchida M, Hanada R, Tsukimoto I, Hayashi Y.
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Journal Title
Peer Reviewed
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[Presentation] Genome-wide analysis of epigenetic abnormalities in neuroblastoma using oligonucleotide tiling array2008
Author(s)
Kato M, Iio M, Takita J, Chen, YY, Nakamura F, Sanada M, Watanabe T, Igarashi T, Ogawa S, Hayashi Y
Organizer
ANR
Place of Presentation
千葉
Year and Date
20080521-24
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