• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2007 Fiscal Year Final Research Report Summary

Mollecular histopathological study for human papillomavirus type-pecific cytopathic effect

Research Project

Project/Area Number 18591254
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionKumamoto University

Principal Investigator

EGAWA Kiyofumi  Kumamoto University, Graduate School of Medical and Pharmaceutical Sciences, Associate Professor (50183215)

Co-Investigator(Kenkyū-buntansha) HONDA Yumi  Kumamoto University, Hospital, Assistant professor (00284761)
Project Period (FY) 2006 – 2007
KeywordsVirus / Cancer / Cell-Tissue / HPV / Stem cell
Research Abstract

Although it is now accepted that there are correlations between human papillomavirus (HPV) types and specific cytopathic changes (HPV-type-specific cytopathic effect: CPE), the true mechanism of the CPE is still unknown. There are as yet little evidences for the target cells of HPVs, either. In a series of previous studies of our own, we found out HPV 60, 63, 65, 88 and 95 in new clinical types of viral warts, in which particular intracytoplasmic inclusion bodies were seen type-specifically. It is now accepted that genus gamma-papillomavirus consists of HPV 4, 48, 50, 60, 65, 88 and 95, while genus mu HPV 1 and 63. A characteristic of these genera is producing various intracytoplasmic inclusion bodies (ICBs) in genotype-specific manner. In the present study, it has been revealed that the heterogeneous ICBs, and their association with specific types of HPV, will provide a useful model for studying the interaction between keratinocytes and HPVs, especially in the functional aspect of E4 gene expression. Aside from the HPV type-specific ICBs, HPV 4/60/65-associated pigmented warts implicate HPV type-specific activation of melanogenesis HPV 60 provides a new clinical entity of HPV-associated epidermoid cysts; a reported double infection with HPV 1 and HPV 63 within a single cell with only HPV 63-associated ICB poses an important problem of a possible interference between the viruses: HPV 63-induced punctuate wart has recently been described as an excellent clue to epidermal stem cells whose exact localization is not yet clear; and HPV 1-induced hypertrichosis observed in a patient suggests that HPV infection not only induce visible lesions but also activate its neighboring epithelium. On the basis of our results, we suggest that the genus gamma- and mu-papiUomaviruses pose important problems to be resolved in virology and human pathology

  • Research Products

    (30 results)

All 2008 2007 2006 Other

All Journal Article (11 results) (of which Peer Reviewed: 3 results) Presentation (9 results) Book (10 results)

  • [Journal Article] A new disorder in UV-induced skin cancer with defective DNA repair distinct from Xeroderma Pigmentosum or Cockayne Syndrome2008

    • Author(s)
      Hashimoto H.
    • Journal Title

      Journal of Investigative Dermatology 128

      Pages: 694-701

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Genuc gamma and mu-papillomaviruses:Clinical and histopathological aspects suggestive of their important roles in virology and human pathology2008

    • Author(s)
      Egawa K.
    • Journal Title

      Current topics in Virology

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A new disorder in UV-induced skin cancer with defective DNA repair distinct from Xeroderma Pigmentosum or Cockayne Syndrome2008

    • Author(s)
      Hashimoto, H
    • Journal Title

      Journal of Investigative Dermatology 128

      Pages: 694-708

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Genuc gamma and mu-papillomaviruses : Clinical and histopathological aspects suggestive of their important roles in virology and human pathology2008

    • Author(s)
      Egawa, K
    • Journal Title

      Current topics in Virology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 鶏眼と足底疣贅の鑑別法2007

    • Author(s)
      江川 清文
    • Journal Title

      Monthly Book Derma 創刊10周年記念号

      Pages: 74-79

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ウイルス性疣贅2007

    • Author(s)
      江川 清文
    • Journal Title

      Monthly Book Derma 127

      Pages: 103-110

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Human papillomavirus as a clue to the anatomical site-specific epidermal stem cells2007

    • Author(s)
      Egawa, K
    • Journal Title

      Stem cells and Cancer(Parsons DW(ed))(Nova Publishers, Inc.) 23-45

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Sarcoidal gxanuloma developing not only at the entry site of industriallubricating oil, but also at a lesional lymphnode and entry points of venepuncture2006

    • Author(s)
      Kogushi H.
    • Journal Title

      Dermatology 213

      Pages: 250-252

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 頭蓋内post-transplantation lymphoma患者の放射線照射部位に初発したTENの1例2006

    • Author(s)
      田上 俊英
    • Journal Title

      西日本皮膚科 68

      Pages: 46-50

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] ウイルス性疣贅のビタミンD3外用療法2006

    • Author(s)
      江川 清文
    • Journal Title

      臨床皮膚科 60

      Pages: 113-117

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Sarcoidal granuloma developing not only at the entry site of industrial lubricating oil, but also at a lesional lymphnode and entry points of venepuncture2006

    • Author(s)
      Kogushi, H
    • Journal Title

      Dermatology 213

      Pages: 250-252

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] HPVについて2007

    • Author(s)
      江川 清文
    • Organizer
      第193回日本皮膚科学熊本地方会
    • Place of Presentation
      熊本
    • Year and Date
      2007-12-02
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Human papillomavirus as a clue to the anatomical site specificepidermat stem cells2006

    • Author(s)
      Egawa K
    • Organizer
      23th International papillomavirus conference and clinical workshop
    • Place of Presentation
      Prague
    • Year and Date
      20060901-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Local hypertrichosis and eccrine duct hyperplasia associated with human papillomavirus type 1 infection2006

    • Author(s)
      Honda Y.
    • Organizer
      23th International papillomavirus conference and clinical workshop
    • Place of Presentation
      Prague
    • Year and Date
      20060901-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Analysis of human papillomavirus in Bowen's disease2006

    • Author(s)
      Kitasato H
    • Organizer
      23th International papillomavirus conference and clinical workshop
    • Place of Presentation
      Prague
    • Year and Date
      20060901-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Different life cycle strategies amongst human papillomaviruses of distinct evolutionary origin2006

    • Author(s)
      Peh WL
    • Organizer
      23th international papillomavirus conference and clinical workshop
    • Place of Presentation
      Prague
    • Year and Date
      20060901-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Human papillomavirus as a clue to the anatomical site-specific epidermal stem cells

    • Author(s)
      Egawa, K
    • Organizer
      23th International papillomavirus conference and clinical workshop
    • Year and Date
      00000901-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Local hypertrichosis and eccrine duct hyperplasia associated with human papillomavirus type 1 infection

    • Author(s)
      Honda, Y
    • Organizer
      23th International papillomavirus conference and clinical workshop
    • Year and Date
      00000901-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Analysis of human papilldinavirus in Bowen's disease

    • Author(s)
      Kitasato, H
    • Organizer
      23th International papillomavirus conference and clinical workshop
    • Year and Date
      00000901-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Different life cycle strategies amongst human papillomaviruses of distinct evolutionary origin

    • Author(s)
      Pen, WL
    • Organizer
      23th International papillomavirus conference and clinical workshop
    • Year and Date
      00000901-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] EBM皮膚疾患の治療2008-20092008

    • Author(s)
      江川 清文
    • Total Pages
      298
    • Publisher
      中外医学社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Stem Cells and Cancer2007

    • Author(s)
      Egawa K.
    • Total Pages
      284
    • Publisher
      Nova Science Publishiers,Inc.
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 看護のための最新医学講座(第2版)19皮膚科疾患2007

    • Author(s)
      江川 清文
    • Total Pages
      421
    • Publisher
      中山書店
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 最新皮膚科学体系2006-20072006

    • Author(s)
      江川 清文
    • Total Pages
      346
    • Publisher
      中山書店
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] WHAT'S NEW in皮膚科学2006-20072006

    • Author(s)
      江川 清文
    • Total Pages
      214
    • Publisher
      メディカルビュー社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 皮膚科専門医テキスト集2000年度2006

    • Author(s)
      江川 清文
    • Total Pages
      333
    • Publisher
      日本皮膚科学会
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 皮膚科診療のコツと落とし穴1症候・症状、診断、検査2006

    • Author(s)
      江川 清文
    • Total Pages
      206
    • Publisher
      中山書店
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 皮膚科診療のコツと落とし穴3疾患II2006

    • Author(s)
      江川 清文
    • Total Pages
      168
    • Publisher
      中山書店
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 皮膚科診療のコツと落とし穴4治療2006

    • Author(s)
      江川 清文
    • Total Pages
      252
    • Publisher
      中山書店
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 臨床病態学32006

    • Author(s)
      江川 清文
    • Total Pages
      594
    • Publisher
      ヌーヴェルヒロカワ
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2010-02-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi