NAGASAKI SCHIZOPHRENIA STUDY A STUDY ON LONG-TERM COURSE AND OUTCOME OF SCHIZOPHRENIA

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18591294
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Nagasaki University
• Principal Investigator: NAKANE Hideyuki Nagasaki University, Graduate School of Biomedical Sciences, Medical and Dental Sciences, Unit of Translational Medicine, Department of Neuropsychiatry, Associate Professor (90274795)
• Co-Investigator(Kenkyū-buntansha): KINOSHITA Hirohisa Nagasaki University, Hospital of Medicine and Dentistry, Department of Neuropsychiatty, Assistant Professor (10380883) ; OZAWA Hirpki Nagasaki University, Graduate School of Biomedical Sciences, Medical and Dental Sciences, Unit of Translational Medicine, Department of Neuropsychiatry, Professor (50260766) ; NAKANE shibumi Nagasaki International University, Graduate School, Major in Social Work, Division of Human Sociology, Professor (80039833)
• Project Period (FY): 2006 – 2007
• Keywords: Schizophrenia / long-term outcome / clinical course / Social function / Quality of life / QOL

Research Abstract

Objective: For many years, The Nagasaki World Health Organization (WHO)Collaborating Center for Research and Training in Mental Health has been participating in a collaborative study of schizophrenia. "WHO Collaborative Study on the Determinants of Outcome of Severe Mental Disorders' (DOSMeD)started in 1976, subjects were first collected in 1979- 1980 for an incidence study of schizophrenia in Nagasaki. 107 patients who visited 30 institutions participating in the case-finding search were registered for this study. The patients were followed from first contact to 1,2,5,10,and 15 years later. 5- and 10-year follow-ups were conducted independently by the Nagasaki Center This time, we are investigating long-term outcomes of schizophrenia in Nagasaki.
Methods : The clinical outcomes of successfully traced patients were evaluated by Positive and Negative Syndrome Scale(PANSS), Scale for the Assessment of Negative Symptoms(SANS), Mini-ICF-Rating for Mental Disorders(Mini-ICF-P), Disability As sessment Schedule(DAS), Life Chart Schedule(LCS), Kate Adjustment Scales(KAS), the 26-item short form of the World Health Organization Quality of Life(WHO-QOL-26), Global Assessment of Functioning Scale(GAF), Global Assessment Scale(GAS)and Clinical Global Impression (CGI).All of the interviews were given by psychiatrists who had performed the reliability exercises for the assessment instruments of this study As a biological indicator, serum brain-derived neurotrophic factor(BDNF) levels of subjects were examined.
Results: So far, we followed up 28 subjects. Major parts of the hospitalized patients were staying for long periods. Others were receiving out-patient treatment A few cases were dead by suicide or from illness. A small minority of subjects were working.
Conclusions : There were various clinical outcomes. Subjects with continuous psychotic symptoms were remarkable. Social function deteriorated in subjects who were hospitalized for long periods. Out-patients were keeping social function to some extent.

Research Products

• [Presentation] 長崎統合失調症研究-統合失調症の超長期経過と転帰について (2008)
  • Author(s): 一ノ瀬 仁志、中根 秀之、木下 裕久、稲富 宏之、太田 保之、小沢 寛樹、中根 允文
  • Organizer: 第27回日本社会精神医学会
  • Place of Presentation: 福岡
  • Year and Date: 2008-02-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Nagasaki Schizophrenia long-term outcome Study (2008)
  • Author(s): H., Ichinose, H., Nakane, H., Kinoshita, H., Inadomi, Y., Ohta, H., Ozawa, Y., Nakane
  • Organizer: 27th Japanese Society of Social Psychiatry
  • Place of Presentation: Fukuoka
  • Year and Date: 2008-02-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] NAGASAKI SCHIZOPHRENIA STUDY:A STUDY ON LONG-TERM COURSE AND OUTCOME OF SCH-ZOPHRENIA (2007)
  • Author(s): H. Ichinose, H. Nakane, H. Kinoshita, Y. Ohta, H.Ozawa, Y. Nakane
  • Organizer: XIXth World Congress of World Association for Social Psvchiaitry
  • Place of Presentation: プラハ
  • Year and Date: 2007-10-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Nagasaki Schizophrenia Study : A STUDY ON LONG-TERM COURSE AND OUTCOME OF SCHIZOPHRENIA (2007)
  • Author(s): H., Ichinose, H., Nakane, H., Kinoshita, Y., Ohta, H., Ozawa, Y., Nakane
  • Organizer: XlXth World Congress of World Association for Social Psychiatry
  • Place of Presentation: Prague
  • Year and Date: 2007-10-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 統合失調症の長期転帰追跡研究-(長期転帰と未治療期間との関連) (2007)
  • Author(s): 木下 裕久、中根 允文、一ノ瀬 仁志、中根 秀之、小沢 寛樹
  • Organizer: 第3回統合失調症研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-02-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The Study of Schizophrenia Long-term outcome (2007)
  • Author(s): H., Kinoshita, Y., Nakane, H., Ichinose, H., Nakane, H., Ozaw
  • Organizer: 3rd Research group for Schizophrenia
  • Place of Presentation: Tokyo
  • Year and Date: 2007-02-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 統合失調症の長期転帰因子の探索 (2006)
  • Author(s): 小沢 寛樹, 木下 裕久, 一ノ瀬 仁志, 中根 秀之, 中根 允文
  • Organizer: 第39回精神神経系薬物治療研究報告会
  • Place of Presentation: 大阪
  • Year and Date: 2006-12-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The quest for predictors of long-term outcome of schizophrenia (2006)
  • Author(s): H., Ozawa, H., Kinoshita, H., Ichinose, H., Nakane, Y., Nakane
  • Organizer: 39th Psychopharmacology Research Association
  • Place of Presentation: Osaka
  • Year and Date: 2006-12-08
  • Description: 「研究成果報告書概要(欧文)」より