2007 Fiscal Year Final Research Report Summary
Underlying cause of a patient elucidation and clinica application of the panic disorder
| Project/Area Number |
18591296
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Oita University |
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Principal Investigator |
AKIYOSHI Jotaro Oita University, Faculty of Msdicine, Department of Neuropsychiatiy, Associate Professor (00159344)
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUMI Takashi Oita University, Department of Neuropsychiatry, Assistant Professor (60284791)
KODAMA Kesuke Oita University, Department of Neuropsychiatry, Assistant instrutor (60398261)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Panic Disorder / Anxiety / Hepatocvte Growth Factor / Ghrelin / Serotonin / GABA / NIRS |
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| Research Abstract |
We investigated basic and clinical research for panic disorder Hist, we examine associate genetic study We could not find the relationship between ghrelin, serotonin receptor 3, mGluR7, mGluRS, GABA receptor alfa-6 subunit, nociceptine/orphanin FQ receptor and panic disorder Second, we examine the role of hepatocyte growth fector (HGF) and ghrelin in animal model of anxiety We injected the antisense of these substances to rafe lateral ventricle by using mini pump. The inhibition of HGF induces an increase in depression and anxiety-related behaviors. HGF might have antidepressive and anxiolytic effect. Administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats. Third, we examine human frontal cortex in healthy volunteers by using near-infrared reflection spectroscopy (NIRS) prior to and during anticipatory anxiety to determine if NIRS could detect any anxiety-related changes. O2Hb levels in the right frontal region correlate with anxiety or heightened negative effect.
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[Journal Article] Serotonin receptor 3A(HTR3A) gene is associated with personality traits, but not panic disorder2008
Author(s)
Mizuta, N., Akiyoshi, J., Sato, A., Hanada, H., Tanaka, Y., Tsuru, J., Matsushita, H., Kodama, K., Isogawa, K.
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Journal Title
Psychiatr Genet 18(1)
Pages: 44
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Ghrelin gene polymorphism is associated with depression, but not panic disorder2008
Author(s)
Nakashima, K., Akiyoshi, J., Hatano, K., Hanada, H., Tanaka, Y., Tsuru, J., Matsushita, H., Kodama, K., Isogawa, K.
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Journal Title
Psychiatr Genet (in print)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Administration of antisense DNA for hepatocyte growth factor causes an depressive and anxiogenic response in rats2007
Author(s)
Wakatsuki, M., AMyoshi, J., Ichioka, S., Tanaka, Y., Tsuru, J., Matsushita, H., Hanada, H., Isogawa, K.
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Journal Title
Neuropeptides 41(6)
Pages: 477-483
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A)receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder2007
Author(s)
Kobayashi, Y., Akiyoshi, J., Kanehisa, M., Ichioka, S., Tanaka, Y., Tsuru, J., Hanada, H., Eodama, K., Isogawa, K., Tsutsumi, T.
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Journal Title
Psychiatr Genet 17(1)
Pages: 9
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Anticipatory anxiety-induced changes in human lateral prefrontal cortex activity2007
Author(s)
Morinaga, K., Akiyoshi, J., Matsushita, H., Ichioka, S., Tanaka, Y., Tsuru, J., Hanada, H.
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Journal Title
Biol Psychol 74(1)
Pages: 34-38
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Administration of antisense DNA for ghrelin causes an antidepressant and anxiolytic response in rats2006
Author(s)
Kanehisa, M., Akiyoshi, J., Kitaichi, T., Matsushita, H., Tanaka, E., Kodama, K., Hanada, H., Isogawa, K.
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Journal Title
Prog Neurop sychopharmacol Biol Psychiaatry 30(8)
Pages: 1403
Description
「研究成果報告書概要(欧文)」より
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