2007 Fiscal Year Final Research Report Summary
Pathophysiological Analysis of Eating Disorder
| Project/Area Number |
18591302
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
SAITO Satoshi Sapporo Medical University, Dept of Neuropsy, Instructor (30295357)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Hiroshi Hokkaido Bunkyc Univ., Dept of Occupational Therapy, Professor (30232193)
HASHIMOTO Eri Sapporo Medical Univ., Dept of Neuropsy, Associate Professor (30301401)
UKAI Wataru Sapporo Medical Univ., Dept of Neuropsy, Assistant Professor (40381256)
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| Project Period (FY) |
2006 – 2007
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| Keywords | eatine disorder / brain-derived neurotorophic factor / body mass index / eating attitudes test / Hamilton depression ratine scale / EAT |
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| Research Abstract |
In the current study, we concluded that there was a positive correlation between the level of brain-derived neurotorophic factor (BDNF) and body mass index (BMI) among patients with eating disorders. In several previous studies have already revealed a close relationship between decreased level of BDNF in blood and depressive symptoms, and the result of this study also showed a negative correlation between the level of BDNF and the score of Hamilton Depression Rating Scale (HDRS), that is consistent with the results of prior studies. In addition, scores of HDRS and Eating Disorder Inventory-2 (EDI-2) showed a positive correlation, suggesting that worsening of depressive symptoms which are affected by the condition of eating disorder could have an influence on decline of BDNF.
On the other hand, regardless of the symptoms of depression, one of the subscales of Eating Attitudes Test (EAT-26) called "oral control" (OC) showed a negative correlation with the level of BDNF, and reduced level
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of BDNF may have contributed to the strictly controlled eating behavior over what to eat and not to eat often seen among patients with eating disorders.
Also, among in-patient anorexic patients who showed a significant BMI increase, we found a tendency of increased level of blood BDNF, but the change itself was not so significant However, since the rate of BMI change was positively correlated with the one of BDNF change, increased level of BDNF could possibly have a considerable effect on the process of recovering body weight among patients with anorexia. There have been reports that BDNF is a crucial factor regulating food intake and energy consumption as well as maintaining body weight Moreover, recently, its relationships with cognitive dysfunction and depressive symptoms also have drawn a great deal of attention from many researchers. For that reason, we believe that it is our responsibility to conduct further research to clarify how cognitive dysfunction and depressive symptoms relates to the condition of eating disorder during the period of recovery, which will bring a new insight on biological role of BDNF in the pathophysiology of eating disorder Less
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