2008 Fiscal Year Final Research Report
Pharmacogenomic research for order-made pharmacotharapeutic treatment planning for panic disorder
| Project/Area Number |
18591307
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
SHIMODA Kazutaka Dokkyo Medical University, 医学部, 教授 (30196555)
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| Co-Investigator(Kenkyū-buntansha) |
SAEKI Yoshinori 獨協医科大学, 医学部, 講師 (20406177)
MUROI Hideta 獨協医科大学, 医学部, 助手 (90383009)
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| Project Period (FY) |
2006 – 2008
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| Keywords | 遺伝子 / ゲノム / 薬物反応性 |
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| Research Abstract |
パニック障害患者を対象にパロキセチンによる治療を行い、初期治療反応性と、パロキセチン血中濃度、セロトニントランスポータープロモーター領域(5-HTTLPR)遺伝子多型との関連について検討した結果、治療反応性と有意な相関がみられたのはパロキセチン血中濃度と5-HTTLPR遺伝子多型であり、他の因子とは有意な相関がみられず、パロキセチン血中濃度高値と5-HTTLPRのL型は初期治療反応性を低下させる因子と考えられた。
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[Presentation] A research of clinical factors which influence the initial therapeutic response of paroxetine in patients with panic disorder2008
Author(s)
T Ayugase, S Ishiguro, T Watanabe, M Ueda, Y Saeki, G Hirokane, S Morita, N Yamada, K Akiyama, K Shimoda
Organizer
21^<st> annual meeting of European College of Neuropsychopharmacology
Place of Presentation
Barcelona, Spain
Year and Date
20080830-20080903
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[Presentation] Effects of CYP2D6 polymorphism on paroxetine concentration and inhibition of serotonin uptake in panic disorder patients treated with paroxetine.2008 International Coferrence on Pharmcogenomics2008
Author(s)
M. Ueda, T. Watanabe, Y. Saeki, S. Ishiguro, T. Ayugase, G. Hirokane, S. Morita, N. Yamada, K. Akiyama, Y. Toyohira, N. Yanagihara, K. Shimoda
Organizer
A Joint Conference with the 14^<th> Annual Meeting of the Pacific Rim Assocation of Clinical Pharmacogentics
Place of Presentation
Busan, Korea
Year and Date
20080409-12
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