2009 Fiscal Year Final Research Report
Neuronal mechanisms of stress-induced hyperarousal : A psychophysiological study in rats
| Project/Area Number |
18591322
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
SHINBA Toshikazu Tokyo Metropolitan Organization for Medical Research, 精神医学総合研究所, 副参事研究員 (80175398)
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| Project Period (FY) |
2006 – 2009
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| Keywords | ストレス / 脳波 / 事象関連電位 / DC電位 / ノルアドレナリン / ラット / 過覚醒 |
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| Research Abstract |
The DC potential at the rat frontal cortex showed a significant diurnal variation, and its negative shifts were accompanied by muscular activation and delta wave suppression, indicating its relationship with arousal level. DC potential shifts were also observed at the frontal cortex on expecting the footshock stress. Acute stress application induced a significant NA increase at the cerebral cortex, hypothalamus and hippocampus 7 days after the footshock stress. These results suggest that stress induces changes in frontal DC potential and noradrenaline activity, leading to generation of hyperarousal state.
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[Journal Article] Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice.2009
Author(s)
Kitamura K, Itou Y, Yanazawa M, Ohsawa M, Suzuki-Migishima R, Umeki Y, Hohjoh H, Yanagawa Y, Shinba T, Itoh M, Nakamura K, Goto Y
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Journal Title
Human Molecular Genetics 18
Pages: 3708-3724
Peer Reviewed
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