2007 Fiscal Year Final Research Report Summary
Basic research of SENDAI stent graft for peripheral artery aneurysm
| Project/Area Number |
18591326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University |
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Principal Investigator |
MATSUHASHI Toshio Tohoku University, TOHOKU UNIVERSITY HOSPITAL, ASSISTANT PROFESSOR (40333819)
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| Project Period (FY) |
2006 – 2007
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| Keywords | covered stent / immunosuppressant / aneurysmal model / elastase |
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| Research Abstract |
(1) Evaluation of microporous covered SENDAI stent graft. This study aimed to evaluate whether drug coating of the recently developed covered SENDAI stents-self-expandable stents covered with segmented polyurethane (SPU) films-reduces neointimal hyperplasia in canine model. FK506, which is one of the most effective immunosuppressants, was used. Bare stents; non-coated covered stents; and FK506-coated covered stents were placed bilaterally in the external iliac arteries of adult beagle dogs. After 1 month observation period, angiography did not show significant stent-induced stenosis. Histological evaluation revealed a completely endothelialized intravascular lumen and the absence of thrombus formation. The area of the intimal hyperplasia induced by the FK506-coated stents was significantly smaller than that induced by the non-coated stents, whereas it was larger in the case of both the covered stents than that in the case of the bare stent. In conclusion, FK506 treatment of the self-expandable, covered stents was confirmed to effectively inhibit neointimal hyperplasia, while the SPU film used for covering functioned as a pharmacological reservoir in addition to a scaffold for neointimal formation.
(2) Endovascular aneurysmal model. Materials and Methods. : The experimental animals were 8 female beagle dogs that weighed 11.0 kg on an average. Double balloon catheter was inserted into. external iliac artery and 2m1 elastase was injected into occluded space for 1 hour. We evaluated its angiographic and histological findings one month after elastase injection. Results.: Aneurysms of external iliac arteries were obserbed one month after elastase injection. Before elastase injection, balloon dilatation of external iliac arteries was necessary.
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