2007 Fiscal Year Final Research Report Summary
Hydrogel-mediated release of basic fibroblast growth factor from a stent-graft accelerates biological fixation with the aortic wall in a porcine mode
| Project/Area Number |
18591333
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
SANADA Junichiro Kanazawa University, University Hospital, Assistant Professor (10313652)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUI Osamu Kanazawa University, Graduate School of Medicine, Professor (10019961)
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| Project Period (FY) |
2006 – 2007
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| Keywords | aortic aneurysm / stent-graft / basic fibroblast growth factor / hydrogel / biological fixation |
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| Research Abstract |
PURPOSE: To evaluate the local reaction of the aortic wall induced by basic fibroblast growth factor (bFGF) released from a gelatin hydrogel coated on the outer surface of a stent-graft for the purpose of biological fixation.
METHODS: A total of 18 nitinol-based, polyester-covered stent-grafts were implanted in 6 porcine aortas for 1 month. The implanted stent-grafts were divided into 3 groups: the control group (uncoated), the hydrogel group (coated with hydrogel containing water), and the bFGF group (coated with hydrogel containing bFGF). After stent-graft implantation, the results of intravascular ultrasound (IVUS) and qualitative and quantitative microscopic examinations were compared among the groups.
RESULTS: In the bFGF group, a thin white lamellar tissue was observed on IVUS images. Significantly more new intimal tissue formation was observed in all the bFGF group animals than in the other 2 groups, and alpha smooth muscle (SM) actin-positive cells (alphaSMCs) were detected in this new tissue. The alphaSMCs within the fabric of tightly woven grafts were significantly more abundant in the bFGF group than in the other groups.
CONCLUSION: The local controlled release of bFGF from the stent-graft significantly accelerated the proliferation of new intimal tissue between the aorta and the stent-graft and within the graft materials. These findings suggest that a graft can be fixed biologically to the aortic wall, which may contribute to the shrinkage of aneurysms following stent-grafting.
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[Journal Article] Hydrogel-mediated release of basic fibroblast growth factor from a stent-graft accelerates biological fixation with the aortic wall in a porcine model2007
Author(s)
Kusanagi, M., Matsui, O., Sanada, J., Ogi, T., Takamatsu, S., Zhong, H., Kimura, Y., Tabata, Y
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Journal Title
J Endovasc Ther 14(6)
Pages: 785-793
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Stent-graft deployment to treat a perigraft seroma formed after descending thoracic aortic surgery2007
Author(s)
Ohtake, H., Kimura, K., Soga, S., Sanada, J., Matsui, O., Watanabe, G
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Journal Title
J Endovasc Ther 14(6)
Pages: 813-815
Description
「研究成果報告書概要(欧文)」より
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