2007 Fiscal Year Final Research Report Summary
Quantitative measurement of regional cerebral perfusion pressure and evaluation of autoregulatory function for cerebral blood flow
| Project/Area Number |
18591334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
OKAZAWA Hidehiko University of Fukui, Bionaedical Imaging Reseamh Center, Professor (50360813)
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| Co-Investigator(Kenkyū-buntansha) |
TSUCHIDA Tatsurou University of Fukui, Hospital, Assistant Professor (70303386)
MORI Tetsuya University of Fukui, Biornedical IrnattingResearch Center, Assistant Professor (40397287)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Cerebral nerfusion / Cerebral nerfusion pressure / Positron emission tranno-renhv / Cerebral ischemic disease / aerebrovascular occlusive disease / Cerebral autorewulation |
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| Research Abstract |
Autoregulatory mechanism to keep cerebral blood flow (CBF) and perfusion pressure may be impaired in patients with cerebrovascular disease. To investigate the critical hemodynamic status in the impaired cerebral circulation, changes in regional CBF and arterial-to-capillary blood volume (Vo) induced by acetazolamide (ACZ) were measured in patients with cerebrovascular disease, as well as changes in hemodynamic parameter defined by CBF/Vo ratio, which is expected to be proportional to the regional perfusion pressure. Patients with unilateral major cerebral arterial occlusive disease underwent H^2 15O-PET at baseline and 10 min after ACZ administration to calculate CBF, Vo and CBF/Vo ratio. The hemodynamic parameters in the territories of bilateral middle cerebral arteries were obtained and compared between the two hemispheres and two conditions. Following ACZ administration, the group of patients who had a reduced CBF response in the ipsilateral hemisphere (= reduced vasodilatory capacity group) showed a significant Vo increase in the same region. Thus, the CBF/Vo ratio decreased significantly after ACZ administration in the ipsilateral hemisphere of patients with reduced vasodilatory capacity. This ratio did not change in the contralateral hemisphere of this group nor in the other group with normal vasodilatory capacity, suggesting that its reduction represented severe hemodynamic impairment and dysfunction of autoregulation for regional perfusion pressure. The significant decrease in CBF/Vo ratio was associated with strokes in patients of reduced vasodilatory capacity. The decrease in the CBF/Vo ratio after ACZ challenge is presumed to represent altered regional cerebral perfusion pressure reflecting a critical hemodynamic status in patients with cerebrovascular disease.
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[Journal Article] Shorter examination method for the diagnosis of misery perfusion using count-based OEF elevation in 15O-Gas PET2008
Author(s)
Kobayashi, M., Kudo, T., Tsujikawa, T., Isozaki, M., Arai, Y., Fujibayashi, Y., Okazawa, H
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Journal Title
J Nuel Med 49
Pages: 242-246
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] 18F-fluorodeoxyglucose positron emission tomography in common enhancing malignant brain tumors2008
Author(s)
Kosaka, N., Tsuchida, T., Uematsu, H., Kimura, H., Okazawa, H., Itoh, H
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Journal Title
Am J Rentogenol (in press)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Can reductions in baseline CBF and vasoreactivity detect misery perfusion in chronic cerebrovascular disease2007
Author(s)
Okazawa, H., Tsuchida, T., Kobayashi, M., Arai, Y., Pagani, M., Isozaki, M., Yonekura, Y
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Journal Title
Eur JNucl Med Mol Imaging 34
Pages: 121-129
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of 5-HT1B/1D receptor agonist rizatriptan on cerebral blood flow and blood volume in normal circulation2006
Author(s)
Okazawa, H., Tsuchida, T., Pagani, M., Mori, T., Kobayashi, M., Tanaka, F., Yonekura, Y
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Journal Title
J Cereb Blood Flow Metab 26
Pages: 92-98
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Diagnosis of misery perfusion using noninvasive 0-15 gas PET2006
Author(s)
Kobayashi, M., Okazawa, H., Tsuchida, T., Kawai, K., Fujibayashi, Y., Yonekura, Y
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Journal Title
J Nuel Med 47
Pages: 1581-1586
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Effect of intravenous adenosine-tri-phosphate (ATP) on cerebral blood flow by bolus 150-labeled water PET study2008
Author(s)
Hussain, H., Tsuchida, T., Kudo, T., Tsujikawa, T., Kobayashi, M., Fujibayashi, Y., Okazawa, H
Organizer
The 13th National Conference of Society of Nuclear Medicine, Bangladesh
Place of Presentation
Khulna (Bangladesh)
Year and Date
2008-02-21
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Potential of shorter examination time for diagnosis of misery perfusion using count-based OEF increase in 0-15 gas PET2007
Author(s)
Kobayashi, M., Okazawa, H., Tsujikawa, T., Tsuchida, T., Isozaki, M., Arai, Y., Kawai, K., Fujibayashi, Y
Organizer
The 54th Annual Meeting of the Society of Nuclear Medicine
Place of Presentation
Washington D.C. (USA)
Year and Date
2007-06-03
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Importance of baseline CBF evaluation for detection of critical hemodynamic status in cerebrovascular disease : Comparison with acetazolamide test using PET2007
Author(s)
Okazawa, H., Tsujikawa, T., Arai, Y., Kobayashi, M., Isozaki, M., Fujibayashi, Y
Organizer
The 23rd International Symposium on Cerebral Blood Flow, Metabolism and Function
Place of Presentation
Osaka
Year and Date
2007-05-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Possibility of scan time reduction for count-based OEF elevation in O-15 gas PET2007
Author(s)
Kobayashi, M., Okazawa, H., Tsujikawa, T., Tsuchida, T., Isozaki, M., Arai, Y., Kawai, K., Fujibayashi, Y
Organizer
The 8th International Conference on Quantification of Brain Function with PET
Place of Presentation
Osaka
Year and Date
2007-05-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Assessment of noninvasive examination method for diagnosis of misery perfusion in [O-151 oxygen-gas PET2006
Author(s)
Kobayashi, M., Okazawa, H., Tsuchida, T., Tsujikawa, T., Isozaki, M., Mai, Y., Kawai, K., Fujibayashi, Y
Organizer
The 9th Congress of World Federation of Nuclear Medicine & Biology
Place of Presentation
Seoul (Korea)
Year and Date
2006-10-22
Description
「研究成果報告書概要(欧文)」より
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[Presentation] How accurately can reductions in baseline CBF and vasoreactivity detect misery perfusion in cerebrovascular disease?2006
Author(s)
Okazawa, H., Tsuchida, T., Arai, Y., Kobayashi, M., Mori, T., Tsujikawa, T., Yonekura, Y., Fujibayashi, Y
Organizer
Annual Congress of the European Association of Nuclear Medicine
Place of Presentation
Athens (Greece)
Year and Date
2006-09-30
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Diagnosis of misery perfusion using noninvasive 15O-gas PET2006
Author(s)
Kobayashi, M., Okazawa, H., Tsuchida, T., Kawai, K., Mori, T., Fujibayashi, Y., Yonekura, Y
Organizer
Annual Congress of the European Association of Nuclear Medicine
Place of Presentation
Athens (Greece)
Year and Date
2006-09-30
Description
「研究成果報告書概要(欧文)」より
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