2007 Fiscal Year Final Research Report Summary
Conelation between degree of differentiation of hepatocellular carcinoma and signal intensity of diffusion-weigted images on 3T MR imaging
| Project/Area Number |
18591341
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
MAETANI Youji Kyoto University, Graduate School of Medicine, Assistant Professor (30324619)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
UEDA Mikiko Kyoto Univ, Graduate School of Medicine, Lecturer (20322159)
HAGA Hironori Kyoto Univ, Graduate School of Medicine, Assistant Professor (10252462)
|
|---|
| Project Period (FY) |
2006 – 2007
|
| Keywords | Hepatocellular carcinoma / degree of differentiation / MR imaging / diffusion weighted images |
|---|
| Research Abstract |
Background: The degree of differentiation of hepatocellular carcinoma (HCC) is reported one of the most important factor that affect the prognosis of patients. Especially, in liver transplantation, the prognosis is reported very poor in patients with poorly-differentiated HCC Therefor, it is very important to speculate the degree of differentiation of HCC preoperatively by radiological technique. Very recently, there a few reports that there may be certain correlation between degree of differentiation of HCC and signal intensity of diffusion-weighted images of MR imaging. In addition, 3T MR imaging can become available in the upper abdominal region recently.
Purpose: To investigate if there is correlation between degree of diffirentiation of HCC and signal intensity of diffusiorr weighted images of 3T MR imaging.
Material and Methods: From 2007.5.11 to 2008.3.20, consecutive 52 patients who underwent hepatectomy or liver transplantation for HCC. The mean age was 57.3 years old. Respiratory triggered diffusion weighted images was performed based on the EM sequence. The scan parameters were as follows: TE=71, b value=0.500.1000. SENSE (turbo factor =2). The signal intensity was evaluated quantitatively in a 5-poiny scale by the consensus of three radiologists. Pathological analysis was performed by one liver pathologist and divided into well, moderate, poorly differentiated HCC. Statistical analysis was underwent Spearman rank correlation.
Results: Them was a good correlation between degree of differentiation of HCC and signal intensity of diffusion-weighted images of MR imaging with the "r"=0.634 and p<0.001.
Conclusion : The diffusion weighted images was considered very useful to speculate the degree of differentiation of HCC. It may influence the theraputic strategy of HCC.
|
-
-
-
-
[Journal Article] CT laparoscopy for detecting small superficial metastatic lesions of the liver surface : initial experience
Author(s)
Maetani, Y., Isoda, H., Nomura, K., Hirokawa, Y., Arizona, S., Shimada, K., Togashi, K
-
Journal Title
AJR 2008 May 190(5)
Pages: 1314-1317
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Efficacy of the Combination of Paging Method and Multiplannar CT images in the Diagnosis of Small Hepatocellular Carcinoma in Liver Transplant Candidates
Author(s)
Maetani, Y., Ueda, M., Haga, H., Takada, Y., Isoda, H., Hirokawa, Y., Arizono, S., Shimada, K
-
Journal Title
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Hepatocellular carcinoma in Patients Undergoing Living-Donor Liver Transplantation. Accuracy of Multi=detector Computed tomogarphy by Viewing Images on Digital Monitors
Author(s)
Maetani, Y., Ueda, M., Haga, H., Takada, Y., Isoda, H., Hirokawa, Y., Arizono, S., Shimada, K
-
Journal Title
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Non-contrast-enhanced hepatic MR angiography with true steady-state free-precession and time spatial labeling inversion pulse : Optimization of the technique and preliminary results
Author(s)
Shimada, K., Isoda, H., Okada, T., Maetani, Y., Hirokawa, Y., Arizona, S., Kamae, T., Togashi, K
-
Journal Title
Eur J Radiology (in press)
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] High Spatial 3D MR cholanghiography Using High Sampling Efficacy Technique (SPACE) at 3T. : Comparison with Conventional Contrast Efficacy Technique Flip Angle Sequence in Healthy Volunteers
Author(s)
Hirokawa, Y., Isoda, H., Maetani, Y., Arizona, S., Shimada, K., Togashi, K
-
Journal Title
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Evalkuation of Motion Correction Effect and Image Quality with the PROPELLAR(BLADE) and Parallel. Imaging Acquisition Tequnique
Author(s)
Hirokawa, Y., Isoda, H., Maetani, Y., Arizono, S., Shimada, K., Togashi, K
-
Journal Title
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Presentation] CT Lapaloscopy for Detecting Small Superficial Metastasis of the Liver Surface2008
Author(s)
Maetani, Y., Isoda, H., Hirokawa, Y., Arizona, S., Shimada, K., Togashi, K
Organizer
European Congress of Radiology
Place of Presentation
Wien, Austria
Year and Date
2008-03-07
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Hepatocellular carcinoma in patients undergoing living-donor liver Transplantation : Accuracy of multidetector computed tomography by Viewing images on digital monitars2007
Author(s)
Maetani, Y., Isoda, H., Hirokawa, Y., Arizono, S., Shimada, K., Togashi, K
Organizer
European congress of Radiology
Place of Presentation
Wien, Austria
Year and Date
2007-03-10
Description
「研究成果報告書概要(欧文)」より
