2008 Fiscal Year Final Research Report
Basic research of molecular imaging for early diagnosis of Alzheimer's disease
| Project/Area Number |
18591369
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Fujita Health University |
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Principal Investigator |
TOYAMA Hiroshi Fujita Health University, 医学部, 准教授 (90247643)
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| Co-Investigator(Renkei-kenkyūsha) |
HATANO Kentaro 国立長寿医療センター研究所, 長寿脳科学研究部, 室長 (50228475)
SAWADA Makoto 名古屋大学, 環境医学研究所, 教授 (10187297)
ITO Kengo 国立長寿医療センター研究所, 長寿脳科学研究部, 部長 (70184653)
KATO Takashi 国立長寿医療センター研究所, 長寿脳科学研究部, 室長 (60242864)
KATADA Kazuhiro 藤田保健衛生大学, 医学部, 教授 (00101684)
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| Research Collaborator |
KUDO Gen 藤田保健衛生大学, 医学部, 講師
ITO Fumitaka 藤田保健衛生大学, 医学部, 助教
OHASHI Masao 藤田保健衛生大学病院, 放射線部, 技師
SUZUKI Hiromi 名古屋大学, 環境医学研究所, 助教
NAKANE Masato 名古屋セントラル病院, 放射線科, 医長
ICHISE Masanori コロンビア大学, 放射線科, 教授
GIUSEPPE Trapani Bari 大学, 薬学部, 教授
ALAN A Wilson トロント大学, 医学部, 准教授
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| Project Period (FY) |
2006 – 2008
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| Keywords | 画像診断学(含放射線診断学、核医学) / アルツハイマー病 / 分子イメージング |
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| Research Abstract |
アルツハイマー病などの神経変性疾患では脳内でグリア細胞であるミクログリア(Mi)が病変部に集積し活性化している。Miが脳内で休止型から活性型になると末梢性ベンゾジアゼピン受容体(PBR)が発現し、PBRの発現とMiの毒性転換に関連性が深いことが示唆されている。ポジトロンCT(PET)を用いて生体内でPBRの発現をモニタリングできれば神経変性疾患の早期診断が可能となる。ラットモデルに対しPETとPBR製剤により、活性型Miを生体内で画像化可能かどうか検討した。活性化した株化Mi細胞で基礎的検討も行った。
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[Journal Article] In-vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand, [^<11>C]PK-11195 and animal PET following ethanol injury in rat striatum.2008
Author(s)
Toyama H, Hatano K, Suzuki H, Ichise M, Momosaki S, Kudo G, Ito F, Kato T, Yamaguchi H, Katada K, Sawada M, Ito K.
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Journal Title
Ann Nucl Med 22
Pages: 417-424
Peer Reviewed
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[Presentation] In-vivo imaging of microglial activation using a novel peripheral benzodiazepine receptor ligand, ^<18>F-FEPPA and animal PET following 6-OHDA injury of the rat striatum ; A comparison with ^<11>C-PK111952008
Author(s)
Kudo G, Toyama H, Hatano K, Suzuki H, Wilson AA, Ichise M, Ito F, Kato T, Katada K, Sawada M, Ito K.
Organizer
7th International Symposium on Neuroreceptor Mapping
Place of Presentation
Pittsburgh, USA
Year and Date
20080717-19
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[Presentation] PET imaging of microglial activation using a novel peripheral benzodiazepine receptor ligand, ^<18>F-FEPPA, in a rat neuroinflammation model2008
Author(s)
Toyama H, Kudo G, Hatano K, Suzuki H, Ichise M, Wilson AA, Kato T, Katada K, Sawada M, Ito K.
Organizer
55^<th> Annual Meeting Society of Nuclear Medicine
Place of Presentation
New Orleans, USA
Year and Date
20080614-18
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[Presentation] In-vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand, ^<11>C-CB148 and animal PET following ethanol injury in rat striatum : A comparison with ^<11>C-PK111952007
Author(s)
Kudo G, Toyama H, Hatano K, Suzuki H, Ichise M, Ito F, Yamaguchi H, Sekimata K, Kato T, Katada K, Serra M, Trapani G, Sawada M, Ito K.
Organizer
54th Annual Meeting Society of Nuclear Medicine
Place of Presentation
Washington DC, USA
Year and Date
20070602-06
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[Presentation] In-vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand2007
Author(s)
Ito F, Kudo G, Toyama H, Hatano K, Suzuki H, Ichise M, Yamaguchi H, Sekimata K, Kato T, Katada K, Serra M, Trapani G, Sawada M, Ito K.
Organizer
^<11>C-CB148 and animal PET following ethanol injury in rat striatum. Brain PET 07
Place of Presentation
Osaka, Japan
Year and Date
20070520-24
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[Presentation] Stereo-tactic imaging of the rat brain lesions using 1.5 T MRI system -Development of reproducible imaging technique without stereo-tactic device2006
Author(s)
Ito F, Kudo G, Toyama H, Suzuki H, Hatano K, Nakane M, Ohashi M, Kato T, Katada K, Ichise M, Sawada M, Ito K.
Organizer
Fifth Annual Meeting of the Society for Molecular Imaging
Place of Presentation
Hawaii, USA
Year and Date
20060830-0902
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[Presentation] In vivo imaging of microglial activation using a peripheral benzodiazepine receptor ligand, [^<11>C]PK11195 and animal PET following implantation of cultured activated microglia into rat siriatum2006
Author(s)
Kudo G, Toyama H, Hatano K, Suzuki H, Ichise M, Ito F, Kato T, Sawada M, Katada K, Ito K.
Organizer
6th International Symposium on Neuroreceptor Mapping
Place of Presentation
Copenhagen, Denmark
Year and Date
20060706-08
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