Cancer Immunotherapy, targets Survivin, and Establishment of Evaluation Methods of Therapeutic Effects

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18591420
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Sapporo Medical University
• Principal Investigator: TSURUMA Tetsuhuro Sapporo Medical University, Department of Surgery, School of Medicine, MD., PhD., Research worker (80381268)
• Co-Investigator(Kenkyū-buntansha): FURUHATA Tomohisa Sapporo Medical University, Department of Surgery, School of Medicine, MD., PhD., Assistant professor (80359992) ; YAMAGUCHI Koji Sapporo Medical University, Department of Surgery, School of Medicine, MD., PhD., Assistant (60315512) ; OHMURA Tosei Sapporo Medical University, Department of Surgery, School of Medicine, MD., PhD., Assistant (30295349) ; SATO Noriyuki Sapporo Medical University, Department of Surgery, School of Medicine, Professor (50158937) ; TORIGOE Tosihiko Sapporo Medical University, Department of Surgery, School of Medicine, Associate Professor (20301400)
• Project Period (FY): 2006 – 2007
• Keywords: cancer / immunotherapy / peptide / pentide vaccine therapy / survivin-2B / IFN-a / Tetramer staining / ELISPOT assay

Research Abstract

In this research, we established firm techniques of tetramer staining and ELTSPOT assay, which could monitor the survivin-2B peptide specific immunological responses. We made out that the vaccination using the surviving-2B peptide with IFA and IFN-a could efficiently induce the peptide specific immunological responses. However, the vaccination could not effectively induce the clinical responses, which have cytoreductive effects in most cases. In many cases which could not be induced the clinical responses, the MHC class I expression level was down-regulated in the primary focus. So, we concluded that the down-regulation of MHC class I expression level might be one of the reasons that the vaccination could not efficiently induce the clinical responses in despite of the induction of the peptide specific Ms. In addition, we investigated the relationship between the MHC class I expression level and the prognosis in cases that were operated in our hospitals. The survival rate of the cases that have the down-regulation of the MHC class I expression level was lower in comparison with the cases that do not have the down-regulation. So the MHC class I expression level might be the novel indication of malignant potential. In this research, we concluded that the most suitable indication of the peptide vaccine therapy might be low-grade cases that the MHC class I expression level was not down-regulated.

Research Products

• [Journal Article] サバイビン2Bペプチドを用いたペプチドワクチン療法 (2008)
  • Author(s): 鶴間 哲弘、平田 公一、鳥越 俊彦、佐藤 昇志
  • Journal Title: G I Research 16 Pages: 3-9
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Disruption of the association of 73 kDa heat shock cognate protein with transporters associated with antigen processing(TAP)decreases TAP-dependent translocation of antigenic peptides into the endoplasmic reticulum (2008)
  • Author(s): Kamiguchi K, Torigoe T, Fujiwara O, Ohshima S, Hirohashi Y, Sahara H, Hirai I, Kohgo Y and Sato N
  • Journal Title: Microbiol Immunol 52 Pages: 94-106
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Clinical and Immunological Evaluation of Anti-apoptosis Protein,Survivin-derived Peptide Vaccine in Phase I CIinical Study for Patients with Advanced or Recurrent Breast Cancer (2008)
  • Author(s): Tsuruma T, Iwayama Y, KatsuramakiT, Hata F, Furuhata T, Yamaguchi K, Kimura Y, Torigoe T, Toyota N, Yagihashi A, Hirohashi Y, Asanuma H, Shimozawa K, Okazaki M, Mizushima Y, Nomura N, Sato N and Hirata K
  • Journal Title: J Transl Med 10 Pages: 24
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Peptide vaccine therapy using survivin-2Bpeptide (2008)
  • Author(s): Tsuruma, T., Hirata, K., Torigoe, T., Sato, N
  • Journal Title: GI Research 16 Pages: 3-9
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Disruption of the association of 73 kDa heat shock cognate protein with transporters associated with antigen processing (TAP) decreases TAP-dependent translocation of antigenic peptides into the endoplasmic reticulum (2008)
  • Author(s): Kamiguchi, K., Torigoe, T., Fujiwara, O., Ohshima, S., Hirohashi, Y., Sahara, H., Hirai, I., Kohgo, Y., Sato, N
  • Journal Title: Microbiol Immunol 52 Pages: 94-106
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinical, Immunological Evaluation of Anti-apoptosis Protein, Survivin-derived Peptide Vaccine in Phase I Clinical Study for Patients with Advanced or Recurrent Breast Cancer (2008)
  • Author(s): Tsuruma, T., Iwayama, Y., Katsuramaki, T., Hata, F., Furuhata, T., Yamaguchi, K., Kimura, Y., Torigoe, T., Toyota, N., Yagihashi, A., Hirohashi, Y., Asanuma, H., Shimozawa, K., Okazaki, M., Mizushima, Y., Nomura, N., Sato, N., Hirata, K
  • Journal Title: J Transl Med 10 Pages: 24
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 癌ワクチン療法 (2007)
  • Author(s): 岩山 祐司、古畑 智久、大村 東生、鶴間 哲弘、平田 公一、佐藤 昇志、鳥越 俊彦
  • Journal Title: 外科治療(増刊) 96 Pages: 378-382
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 「癌診療ガイドライン」の基本的理念と検証法 (2007)
  • Author(s): 平田 公一、古畑 智久、大村 東生、山口 浩司、木村 康利、太田 盛道
  • Journal Title: 消化器外科 30 Pages: 1823-1836
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Down-regulation of HLA class I antigen is an independent prognostlcfactor for clear cell renal cell carcinoma (2007)
  • Author(s): Kitamura H, Honma I, Torigoe T, Asanuma H, Sato N and Tsukamoto T
  • Journal Title: J Urol 177 Pages: 1269-1272
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Down-regulation of HLA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition (2007)
  • Author(s): Kitamura H, Torigoe T, Asanum a H, Honma I, Sato N and Tsukamoto T
  • Journal Title: J Orol 178 Pages: 692-696
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Efficient cross-presentation by heat shock protein 90-peptide complex-loaded dendritic cells via an endosomal pathway (2007)
  • Author(s): Kurotaki T, Tamura Y, Ueda G, Oura J, Kutomi G, Hirohashi Y, Sahara H, Torigoe T, Hiratsuka H, Sunakawa H, Hirata K and Sato N
  • Journal Title: J Immunol 179 Pages: 1803-1813
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cancer vaccine therapy (2007)
  • Author(s): Iwayama, Y., Furuhata, T., Ohmura, T., Tsuruma, T., Hirata, K., Sato, N., Torigoe, T
  • Journal Title: Surgical Thertapy 96 Pages: 378-382
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The basic principle and validation approach of guideline of cancer treatment (2007)
  • Author(s): Hirata, K., Furuhata, T., Ohmura, T., Yamaguchi, K., Kimura, Y., Ohta, M
  • Journal Title: Gastroenterological Surgery 30 Pages: 1823-1836
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Down-regulation of HLA class I antigen is an independent prognostic factor for clear cell renal cell carcinoma (2007)
  • Author(s): Kitamura, H., Honma, I., Torigoe, T., Asanuma, H., Sato, N., Tsukamoto, T
  • Journal Title: J Urol 177 Pages: 1269-1272
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Down-regulation of HLA class I antigens in prostate cancer tissues and up-regulation by histone deacetylase inhibition (2007)
  • Author(s): Kitamura, H., Torigoe, T., Asanuma, H., Honma, I., Sato, N., Tsukamoto, T
  • Journal Title: J Orpl 178 Pages: 692-696
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Efficient cross-presentation by heat shock protein 90-peptide complex-loaded dendritic cells via an endosomal pathway (2007)
  • Author(s): Kurotaki, T., Tamura, Y., Ueda, G., Oura, J., Kutomi, G., Hirohashi, Y., Sahara, H., Torigoe, T., Hiratsuka, H., Sunakawa, H., Hirata, K., Sato, N
  • Journal Title: J Immunol 179 Pages: 1803-1813
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] 癌ワクチン療法の概念と現状 (2006)
  • Author(s): 平田 公一、鶴間 哲弘、鳥越 俊彦、佐藤 昇志
  • Journal Title: Surgery Frontier 13 Pages: 231-233
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Inhibitor of apoptosis protein (IAP)由来サバイビン2B癌ワクチン (2006)
  • Author(s): 鶴間 哲弘、平田 公一
  • Journal Title: Surgery Frontier 13 Pages: 239-244
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The concept and present state of cancer vaccine therapy (2006)
  • Author(s): Hirata, K., Tsuruma, T., Torigoe, T., Sato, N
  • Journal Title: Surgery Frontier 13 Pages: 231-233
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Anti-apoptosis protein, survivin-derived protein vaccine (2006)
  • Author(s): Tsuruma, T., Hirata, K
  • Journal Title: Surgery Frontier 13 Pages: 239-244
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] HDAC阻害剤による癌免疫逃避の制御 (2007)
  • Author(s): 浅沼 広子、鳥越 俊彦、豊田 宣彦、鶴間 哲弘、平田 公一、長谷川 匡、佐藤 昇志
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 新規大腸癌抗原候補遣伝子C20orf42の機能解析 (2007)
  • Author(s): 桐山 賢二、廣橋 良彦、鳥越 俊彦、中津川 宗秀、井野田 智子、岩山 祐司、鶴間 哲弘、古畑 智久、平田 公一、佐藤 昇志
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A novel centrosomal protein c10orf3,as the potential breast cancer antigen (2007)
  • Author(s): 井野田 智子、鳥越 俊彦、廣橋 良彦、中津川 宗秀、桐山 賢二、鶴間 哲弘、岩山 祐司、豊田 宣彦、大村 東生、平田 公一、坂巻 純夫、石谷 邦彦、佐藤 昇志
  • Organizer: 第37回日本免疫学会総会
  • Place of Presentation: 東京
  • Year and Date: 2007-11-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A control of cancer immune escape by HDAC inhibitor (2007)
  • Author(s): Asanuma, H., Torigoe, T., Toyota, N., Tsuruma, T., Hirata, K., Hasegawa, T., Sato, N
  • Organizer: 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-11-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The performance analysis of C20orf42, a novel colon cancer tumor antigen (2007)
  • Author(s): Kiriyama, K., Hirohashi, Y., Torigoe, T., Nakatsugawa, M., Inoda, T., Iwayama, Y., Tsuruma, T., Furuhata, T., Hirata, K., Sato, N
  • Organizer: 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-11-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A novel centrosomal protein c10orf3, as the potential breast cancer antigen (2007)
  • Author(s): Inoda, T., Torigoe, T., Hirohashi, Y., Nakatsugawa, M., Kiriyama, K., Tsuruma, T., Iwayama, Y., Toyota, N., Ohmura, T., Hirata, K., Sakamaki, S, Ishitani, K., Sato, N
  • Organizer: 37th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-11-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] がん免疫療法の確立化へむけて-免疫療法導入の最適時期は (2007)
  • Author(s): 岩山 祐司、古畑 智久、大村 東生、山口 浩司、水口 徹、木村 康利、鶴間 哲弘、鳥越 俊彦、佐藤 昇志、平田 公一
  • Organizer: 第45回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2007-10-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] To establish cancer immune therapy : When shall we start immune therapy? (2007)
  • Author(s): Iwayama, Y., Furuhata, T., Ohmura, T., Yamaguchi, K., Mizuguchi, T., Kimura, Y., Tsuruma, T., Torigoe, T., Sato, N., Hirata, K
  • Organizer: 45th Annual Meeting of Japan Society of Clinical Oncology
  • Place of Presentation: Osaka
  • Year and Date: 2007-10-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 乳癌におけるHLA class I発現の低下と予後 (2007)
  • Author(s): 豊田 宣彦、岩山 祐司、鶴間 哲弘、大村 東生、鳥越 俊彦、平田 公一、佐藤 昇志
  • Organizer: 第35回日本臨床免疫学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A decrease of HLA class I expression and the prognosis in breast cancer (2007)
  • Author(s): Toyota, N., Iwayama, Y., Tsuruma, T., Ohmura, T., Torigoe, T., Hirata, K., Sato, N
  • Organizer: 35th Annual Meeting of the Japan Society for Clinical Immunology
  • Place of Presentation: Osaka
  • Year and Date: 2007-10-19
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] HLAクラスI発現低下によるがん免疫監視機構からのエスケープ〜HLAクラスI発現低下が予後に及ぼす影響 (2007)
  • Author(s): 松村 将之、鶴間 哲弘、岩山 祐司、豊田 宣彦、木村 康利、鳥越 俊彦、佐藤 昇志、平田 公一
  • Organizer: 第20回日本バイオセラピイ学会学術集会総会
  • Place of Presentation: 札幌
  • Year and Date: 2007-10-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 乳癌における腫瘍組織のHLA class I発現低下と免疫逃避 (2007)
  • Author(s): 豊田 宣彦、岩山 祐司、鶴間 哲弘、鳥越 俊彦、平田 公一、佐藤 昇志
  • Organizer: 第20回日本バイオセラピイ学会学術集会総会
  • Place of Presentation: 札幌
  • Year and Date: 2007-10-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A decrease of MHC class I expression level in breast cancer and an immune escape (2007)
  • Author(s): Toyota, N., Iwayama, Y., Tsuruma, T., Torigoe, T., Hirata, K., Sato, N
  • Organizer: 20th Annual Congress of Japan Society for Biological Therapy
  • Place of Presentation: Sapporo
  • Year and Date: 2007-10-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] An escape from cancer immune system by a decrease of HLA class I expression level : A decrease of HLA class I expression level influence the prognosis (2007)
  • Author(s): Matsumura, M., Tsuruma, T., Iwayama, Y., Toyota, N., Kimura, Y., Torigoe, T., Sato, N., Hirata, K
  • Organizer: 20th Annual Congress of Japan Society for Biological Therapy
  • Place of Presentation: Sapporo
  • Year and Date: 2007-10-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] サバイビン2Bペプチドワクチン療法臨床試験〜免疫療法の最適な位置づけ (2007)
  • Author(s): 岩山 祐司、鶴間 哲弘、古畑 智久、山口 浩司、大村 東生、木村 康利、鳥越 俊彦、佐藤 昇志
  • Organizer: 第20回日本バイオセラピイ学会学術集会総会
  • Place of Presentation: 札幌
  • Year and Date: 2007-10-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Clinical study of Survivin-2B peptide vaccine therapy : the most suitable position of immunotherapy (2007)
  • Author(s): Iwayama, Y., Tsuruma, T., Furuhata, T., Yamaguchi, K., Ohmura, T., Kimura, Y., Torigoe, T., Sato, N
  • Organizer: 20th Annual Congress of Japan Society for Biological Therapy
  • Place of Presentation: Sapporo
  • Year and Date: 2007-10-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] C20orf42 is a novel tumor antigen that is applicable to immunotherapy fo rcolon cancer (2007)
  • Author(s): 桐山 賢二、廣橋 良彦、鳥越 俊彦、中津川 宗秀、井野田 智子、岩山 祐司、鶴間 哲弘、古畑 智久、平田 公一、佐藤 昇志
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Prognostic significance of HLA class I down-regulation in breast cancer (2007)
  • Author(s): 豊田 宣彦、岩山 祐司、鶴間 哲弘、鈴木 康代、大村 東生、鳥越 俊彦、平田 公一、佐藤 昇志
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] C20orf42 is a novel tumor antigen that is applicable to immunotherapy for colon cancer (2007)
  • Author(s): Kiriyama, K., Hirihashi, Y., Torigoe, T., Nakatsugawa, M., Inoda, T., Iwayama, Y., Tsuruma, T., Furuhata, T., Hirata, K., Sato, N
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Year and Date: 2007-10-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Prognostic significance of HLA class I down-regulation in breast cancer (2007)
  • Author(s): Toyota, N., Iwayama, Y., Tsuruma, T., Suzuki, Y., Ohmura, T., Torigoe, T., Hirata, K., Sato, N
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Year and Date: 2007-10-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Immunogenicity and clinical application of a novel breast cancer antigen,c10orf3 (2007)
  • Author(s): 井野田 智子、鳥越 俊彦、廣橋 良彦、中津川 宗秀、桐山 賢二、坂巻 純夫、石谷 邦彦、鶴間 哲弘、平田 公一、佐藤 昇志
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A case of advanced pancreatic cancer that showed efficient clinical responses to survivin-peptide vaccine therapy (2007)
  • Author(s): 岩山 祐司、鳥越 俊彦、古畑 智久、大村 東生、山口 浩司、水口 徹、木村 康利、鶴間 哲弘、高橋 あかり、佐藤 昇志、平田 公一
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2007-10-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Immunogenicity and clinical application of a novel breast cancer antigen, c10orf3 (2007)
  • Author(s): Inoda, T., Torigoe, T., Hirohashi, Y., Nakatsugawa, M., Kiriyama, K., Sakamaki, S., Ishitani, K., Tsuruma, T., Hirata, K., Sato, N
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Year and Date: 2007-10-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A case of advanced pancreatic cancer that showed efficient clinical responses to survivin-peptide vaccine therapy (2007)
  • Author(s): Iwayama, Y., Torigoe, T., Furuhata, T., Ohmura, T., Yamaguchi, K., Mizuguchi, T., Kimura, Y., Tsuruma, T., Takahashi, A., Sato, N., Hirata, K
  • Organizer: 66th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Yokohama
  • Year and Date: 2007-10-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 免疫監視機構からのエスケープによる予後規定因子:HLAクラスI発現について (2007)
  • Author(s): 松村 将之、岩山 祐司、鶴間 哲弘、木村 康利、古畑 智久、大村 東生、山口 浩司、桂巻 正、鳥越 俊彦、佐藤 昇志、平田 公一
  • Organizer: 第28回癌免疫外科研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-05-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] HLA class I expression : a prognostic indicator by the escape from immune system (2007)
  • Author(s): Matsumura, M., Iwayama, Y., Tsuruma, T., Kimura, Y., Furuhata, T., Ohmura, T., Yamaguchi, K., Katsuramaki, T., Torigoe, T., Sato, N., Hirata, K
  • Organizer: 28th Japanese Research Society of Surgical Cancer Immunology
  • Place of Presentation: Tokyo
  • Year and Date: 2007-05-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ペプチドワクチン療法 如何に抗腫瘍効果を誘導するか〜サバイビン2Bペプチドワクチン療法臨床試験から得られたもの (2006)
  • Author(s): 岩山 祐司、鶴間 哲弘、桂巻 正、古畑 智久、山口 浩司、木村 康利、鳥越 俊彦、佐藤 昇志、平田 公一
  • Organizer: 第19回バイオセラピイ学会学術集会総会
  • Place of Presentation: 福岡
  • Year and Date: 2006-12-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Peptide vaccine therapy to induce anti-tumor effects : clinical study of survivin-2B peptide vaccine therapy (2006)
  • Author(s): Iwayama, Y., Tsuruma, T., Katsuramaki, T., Furuhata, T., Yamaguchi, K., Kimura, Y., Torigoe, T., Sato, N., Hirata, K
  • Organizer: 19th Annual Congress of Japan Society for Biological Therapy
  • Place of Presentation: Fukuoka
  • Year and Date: 2006-12-01
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] セントロゾーム局在性新規乳癌抗原分子C10orf3の解析 (2006)
  • Author(s): 井野田 智子、鳥越 俊彦、廣橋 良彦、五十嵐 健史、中津川 宗秀、桐山 賢二、佐藤 昇志、坂巻 純夫、石谷 邦彦、鶴間 哲弘、平田 公一
  • Organizer: 第65回日本癌学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2006-09-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Analysis of centrosomal protein c10orf3. (2006)
  • Author(s): Inoda, T., Torigoe, T., Hirohashi, Y., Igarashi, T., Nakatsugawa, M., Kiriyama, K., Sato, N., Sakamaki, S., Ishitani, K., Tsuruma, T., Hirata, K.
  • Organizer: 65th Annual Meeting of the Japanese Society for Immunology
  • Place of Presentation: Yokohama
  • Year and Date: 2006-09-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] MHC class Iの発現異常は、癌悪性度の指標となりうるか (2006)
  • Author(s): 岩山 祐司、鶴間 哲弘、古畑 智久、大村 東生、山口 浩司、桂巻 正、秦 史壮、鳥越 俊彦、佐藤 昇志
  • Organizer: 第61回日本消化器外科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2006-07-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Could the decrease of MHC class I expression level be a marker of malignant potential? (2006)
  • Author(s): Iwayama, Y., Tsuruma, T., Furuhata, T., Ohmura, T., Yamaguchi, K., Katsuramaki, T., Hata, F., Torigoe, T., Sato, N
  • Organizer: 61_st Annual Meeting of the Japanese Society of Gastroenterological Surgery
  • Place of Presentation: Yokohama
  • Year and Date: 2006-07-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ペプチド療法および積極的外科切除にて長期生存している悪性黒色腫の1例 (2006)
  • Author(s): 鶴間 哲弘、古畑 智久、秦 史壮、川崎 浩之、澤田 健、山口 浩司、廣崎 邦紀、神保 孝一、平田 公一
  • Organizer: 第31回日本外科系連合学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2006-06-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A case report that peptide vaccine therapy, surgical removal offered a long-term survival (2006)
  • Author(s): Tsuruma, T., Furuhata, T., Hata, F., Kawasaki, H., Sawada, T., Yamaguchi, K., Hirosaki, K., Jinbo, K., Hirata, K
  • Organizer: 31th Annual Congress of Japanese College of Surgeons
  • Place of Presentation: Kanazawa
  • Year and Date: 2006-06-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Stage ii大腸癌のHLA Class I発現異常と再発・予後因子との関係 (2006)
  • Author(s): 岩山 祐司、鶴間 哲弘、古畑 智久、大村 東生、山口 浩司、桂巻 正、秦 史壮、鳥越 俊彦、佐藤 昇志、平田 公一
  • Organizer: 第27回癌免疫外科研究会
  • Place of Presentation: 北九州
  • Year and Date: 2006-06-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The relationship between HLA class I expression level and the factor of recurrence and prognosis (2006)
  • Author(s): Iwayama, Y., Tsuruma, T., Furuhata, T., Ohmura, T., Yamaguchi, K., Katsuramaki, T., Hata, F., Torigoe, T., Sato, N., Hirata, K
  • Organizer: 27th Japanese Research Society of Surgical Cancer Immunology
  • Place of Presentation: Kita-kyushu
  • Year and Date: 2006-06-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] サバイビン2Bペプチドによるペプチドワクチン療法:免疫モニタリング、臨床効果判定法の確立化にむけて (2006)
  • Author(s): 鶴間 哲弘、岩山 祐司、古畑 智久、山口 浩司、木村 康利、桂巻 正、下澤 久美子、鳥越 俊彦、佐藤 昇志、平田 公一
  • Organizer: 第27回癌免疫外科研究会
  • Place of Presentation: 北九州
  • Year and Date: 2006-06-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Peptide vaccine therapy with survivin-2B peptide : To establish the immunological monitoring technique and the methods of estimation of clinical responses (2006)
  • Author(s): Tsuruma, T., Iwayama, Y., Furuhata, T., Yamaguchi, K., Kimura, Y., Katsuramaki, T., Shimozawa, K., Torigoe, T., Sato, N., Hirata, K
  • Organizer: 27th Japanese Research Society of Surgical Cancer Immunology
  • Place of Presentation: Kita-kyushu
  • Year and Date: 2006-06-01
  • Description: 「研究成果報告書概要(欧文)」より