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2008 Fiscal Year Final Research Report

Mechanism of multicentric carcinogenesis and prevention of the second cancer in the upper aerodigestive induced by cigarette smoking and alcohol drinking

Research Project

  • PDF
Project/Area Number 18591467
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

MORITA Masaru  Kyushu University, 大学病院, 講師 (30294937)

Project Period (FY) 2006 – 2008
Keywords食道癌 / 喫煙 / 飲酒 / p53 / FHIT / アルデヒド / 酸化的DNA損傷
Research Abstract

食道癌の発生には喫煙・飲酒の関与が大きい。本研究にて、食道癌では癌抑制遺伝子p53の変異頻度が高く、中でもタバコ煙中のベンツピレンがもたらすトランスバージョン変異が多いことが明らかとなった。さらに癌抑制遺伝子FHITの低下が飲酒による食道多発癌の発生と関与していることが示唆された。一方、動物実験にてアルデヒド脱水素酵素の異常とアルデヒドの蓄積がアルコールによる発癌に関与していることが示唆された。

  • Research Products

    (37 results)

All 2009 2008 2007 2006

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (13 results) Book (3 results)

  • [Journal Article] The difference in p53 mutations between cancers of the upper and lower gastrointestinal tract2009

    • Author(s)
      Oki E, Zhao Y, Yoshida R, Egashira A, Ohgaki K, Morita M, Kakeji Y, Maehara Y.
    • Journal Title

      Digestion 79 Suppl 1

      Pages: 33-39

    • Peer Reviewed
  • [Journal Article] Preoperative chemoradiotherapy for esophageal cancer : Factors associated with clinical response and postoperative complications2009

    • Author(s)
      Morita M, Masuda T, Okada S, Yoshinaga K, Saeki H, Tokunaga E, Endo K, Emi Y, Kakeji Y, Maehara Y.
    • Journal Title

      Anticancer Res (印刷中)

    • Peer Reviewed
  • [Journal Article] Acute Lung Injury following an Esophagectomy for Esophageal Cancer : With special Reference to the Clinical Factors and Cytokine Levels of Peripheral Blood and Pleural Drainage Fluid2008

    • Author(s)
      Morita M, Yoshida R, Ikeda K, Egashira A, Oki E, Sadanaga N, Kakeji Y, Ichiki Y, Sugio K, Yasumoto K, Maehara Y
    • Journal Title

      Dis Esophagus 21

      Pages: 30-36

    • Peer Reviewed
  • [Journal Article] Successful treatment of tracheomediastinal fkistula after tracheal injury obtained during esophagectomy using pectoralis major muscle : a case report2008

    • Author(s)
      Koga T, Morita M, Nishida K, Oki E, Kakeji Y, Maehara Y
    • Journal Title

      Esophagus 5

      Pages: 41-44

    • Peer Reviewed
  • [Journal Article] Advances in esophageal cancer surgery in Japan : An analysis of 1000 consecutive patients treated at a single institute2008

    • Author(s)
      Morita M, Yoshida R, Ikeda K, Egashira A, Oki E, Sadanaga N, Kakeji Y, Yamanaka T, Maehara Y
    • Journal Title

      Surgery 143

      Pages: 499-508

    • Peer Reviewed
  • [Journal Article] Esophagectomy in patients 80 years of age and older with carcinoma of the thoracic esophagus2008

    • Author(s)
      Morita M, Egashira A, Yoshida R, Ikeda K, Ohgaki K, Sibahara K, Oki E, Sadanaga N, Kakeji Y, Maehara Y
    • Journal Title

      J Gastroenterol 43

      Pages: 345-351

    • Peer Reviewed
  • [Journal Article] Expression of Cytochrome P450 in non-small cell lung cancer2008

    • Author(s)
      Oyama T, Sugio K, Isse T, Matsumoto A, Nose N, Uramoto H, Nozoe T, Morita M, Kagawa N, Osaki T, Muto M, Yasumoto K, Kawamoto T
    • Journal Title

      Front Biosci 13

      Pages: 5787-5793

    • Peer Reviewed
  • [Journal Article] Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice2008

    • Author(s)
      Matsumoto A,Kawamoto T,Mutoh F,Isse T, Oyama T,Kitagawa K,Nakayama KI,Ichiba M
    • Journal Title

      Pharmacogenet Genom 18

      Pages: 847-852

    • Peer Reviewed
  • [Journal Article] Increased frequencies of micronucleated reticulocytes and T-cell receptor mutation in Aldh2 knockout mice exposed to acetaldehyde2008

    • Author(s)
      Kunugita N, Isse T, Oyama T, Kitagawa K, Ogawa M, Yamaguchi T, Kinaga T, KawamotoT
    • Journal Title

      J Toxicol Sci 33

      Pages: 31-36

    • Peer Reviewed
  • [Journal Article] Expression of p53 and p21 and clinical response for hyperthermochemoradiotherapy in patients with squamous cell carcinoma of the esophagus2007

    • Author(s)
      Ishida M, Morita M, Saeki H, Ohga T, Sadanaga N, Watanabe M, Kakeji Y, Maehara Y
    • Journal Title

      Anticancer Res 27

      Pages: 3501-3506

    • Peer Reviewed
  • [Journal Article] Promotoer hypermethylation and quantitative expression analysis of CDKN2A( p14^<ARF> and p16^<IK4a>)gene in esophageal squamous cell carcinoma2007

    • Author(s)
      Ito S, Ohga T, Saeki H, Watanabe M, KakejiY, Morita M, Yamada T, Maehara Y
    • Journal Title

      Anticancer Res 27

      Pages: 3345-3354

    • Peer Reviewed
  • [Journal Article] Clinical significance of cytokeratin positive cells in bone marrow of gastric cancer patients2007

    • Author(s)
      Oki E, Kakeji Y, Baba H, Nishida K, Koga T, Tokunaga E, Egashira A, Ikeda K, Yoshida R, Yamamoto M, Morita M, Maehara Y
    • Journal Title

      J Cancer Res Clin Oncol 133

      Pages: 995-1000

    • Peer Reviewed
  • [Journal Article] Salvage esophagectomy after definitive chemoradiotherapy for esophageal cancer2007

    • Author(s)
      Oki E, Morita M, Kakeji Y, Ikebe M, Sadanaga N, Egasira A, Nishida K, Koga T, Ohata M, Honboh T, Yamamoto M, Baba H, Maehara Y
    • Journal Title

      Dis Esophagus 20

      Pages: 301-304

    • Peer Reviewed
  • [Journal Article] p53 gene mutations in esophageal squamous cell carcinoma and their relevance to etiology and pathogenesis : results in Japan and comparisons with other countries2007

    • Author(s)
      Egashira A, Morita M, Kakeji Y, SadanagaN, Oki E, Honbo T, Ohta M, Maehara Y
    • Journal Title

      Cancer Sci 98

      Pages: 1152-1156

    • Peer Reviewed
  • [Journal Article] Susceptibility to inhalation toxicity of acetaldehyde in Aldh2 knockout mice2007

    • Author(s)
      Oyama T, Isse T, Ogawa M, Muto M, UchiyamaI, Kawamoto T
    • Journal Title

      Front Biosci 12

      Pages: 1927-1934

    • Peer Reviewed
  • [Journal Article] Cytochrome P450 expression(CYP)in non-small cell lung cancer2007

    • Author(s)
      Oyama T, Sugio K, Uramoto H, Kawamoto T, Kagawa N, Nadaf S, Carbone D, Yasumoto K
    • Journal Title

      Front Biosci 12

      Pages: 2299-2308

    • Peer Reviewed
  • [Journal Article] Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis2007

    • Author(s)
      Oyama T, Sugio K, Uramoto H, Iwata T, Onitsuka T, Isse T, Nozoe T, Kagawa N, Yasumoto K, Kawamoto T
    • Journal Title

      Front Biosci 12

      Pages: 4497-4503

    • Peer Reviewed
  • [Journal Article] A pilot study on subacute ethanol treatment of Aldh2 KO mice2007

    • Author(s)
      Oyama T, Kim YD, Isse T, Pham TTP, OgawaM, Yamaguchi T, Kinaga T, Yashima Y, KimH, Kawamoto T
    • Journal Title

      J Toxicol Sci 32

      Pages: 421-428

    • Peer Reviewed
  • [Journal Article] Expressionof FHIT in esophageal epithelium and carcinoma : Reference to drinking, smoking and multicentric carcinogenesis2006

    • Author(s)
      Morita M, Oyama T, Nakata S, Ono K, SugayaM, Uramoto H, Yoshimatsu T, Hanagiri T, Sugio K, Yasumoto K
    • Journal Title

      Anticancer Res 26

      Pages: 2243-2248

    • Peer Reviewed
  • [Journal Article] The metylation stqatus and protein expression of CDH1, p16INK4A, and fragile histidine triad in nonsmall cell lung carcinoma2006

    • Author(s)
      Nakata S, Sugio K, Uramoto H, Oyama T, Hananagiri T, Morita M, Yasumoto K
    • Journal Title

      Cancer 106

      Pages: 2190-2199

    • Peer Reviewed
  • [Journal Article] Impact of loss of heterozygosity of encoding phosphate and tensin homolog on the prognosis of gastric cancer2006

    • Author(s)
      Oki E, Kakeji Y, Baba H, Tokunaga E, Nakamura T, Ueda N, Futatsugi M, Yamamoto M, Ikebe M, Maehara Y
    • Journal Title

      J Gastroenterol Hepatol 21

      Pages: 814-818

    • Peer Reviewed
  • [Presentation] 食道癌におけるp53蛋白発現とp53遺伝子解析の意義2008

    • Author(s)
      沖英次、森田勝、安藤幸滋、杉山雅彦、増田隆伸、吉田倫太郎、今村一郎、大垣吉平、芝原幸太郎、定永倫明、掛地吉弘、前原喜彦
    • Organizer
      第62回日本食道学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      20080621-22
  • [Presentation] 消化器癌におけるp53変異解析とマイクロサテライト不安定性解析の診断的意義2008

    • Author(s)
      沖英次、掛地吉弘、趙岩、吉田倫太郎、岡田敏子、増田隆伸、大垣吉平、今村一郎、芝原幸太郎、定永倫明、森田勝、前原喜彦
    • Organizer
      第94回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      20080508-10
  • [Presentation] The spectrum of mutation and the frequency of allelic deletion of the p53 gene in gastrointestinal cancer : The difference between the upper and lower digestive tract2008

    • Author(s)
      Oki E, Kakeji Y, Ohgaki K, Shibahara K, Imamura I, Sadanaga N, Morita M, Maehara Y
    • Organizer
      2008 ASCO Gastrointestinal Cancers Symposium
    • Place of Presentation
      Orlando,USA
    • Year and Date
      20080125-27
  • [Presentation] The difference p53 abnormalities between cancer of the upper and lower digestive tract2007

    • Author(s)
      Oki E, Kakeji Y, Ohgaki K, Shiotani S, Imamura I, Shibahara K, Yoshida R, Egashira A, Sadanaga N, Morita M, Maehara Y
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20071003-05
  • [Presentation] p53遺伝子変異スペクトラムからみた消化管癌における治療戦略2007

    • Author(s)
      沖英次、掛地吉弘、森田勝、吉田倫太郎、池田圭介、太田光彦、本坊拓也、江頭明典、定永倫明、前原喜彦
    • Organizer
      第62回日本消化器外科学会定期学術総会
    • Place of Presentation
      東京
    • Year and Date
      20070718-20
  • [Presentation] 食道癌におけるp53異常の意義-遺伝子変異スペクトラムの解析と他臓器癌との比較2007

    • Author(s)
      沖英次、森田勝、江頭明典、岡田敏子、増田隆伸、池田圭介、吉田倫太郎、太田光彦、本坊拓也、定永倫明、掛地吉弘、前原喜彦
    • Organizer
      第61回日本食道学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20070621-22
  • [Presentation] Recent advance of surgical treatment for esophageal cancer in Japan : Anexperience of 1000 cases that underwent esophagectomy in a single institute2007

    • Author(s)
      Morita M, Okada S, Masuda T, Ikeda K, Yoshida R, Honboh T, Ohta M, Egashira A, Oki E, Sadanaga N, Kakeji Y, Maehara Y
    • Organizer
      The 43rd Annual Meeting of American Society of Clinical Oncology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      20070601-05
  • [Presentation] 呼吸器系組織におけるアセトアルデヒド感受性2007

    • Author(s)
      小山倫浩、一瀬豊日、PHAM Thi Thu Phuong、小川真規、山口哲右、木長健、八嶋康典、尾崎真一、松本明子、市場正良、欅田尚樹、川本俊弘
    • Organizer
      第80回日本産業衛生学会
    • Place of Presentation
      大阪
    • Year and Date
      20070425-27
  • [Presentation] 食道癌におけるp53異常に注目した発癌分子機構の解析2006

    • Author(s)
      江頭明典、森田勝、池田圭介、吉田倫太郎、太田光彦、本坊拓也、沖英次、織田信弥、掛地吉弘、前原喜彦
    • Organizer
      第65回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      20060928-30
  • [Presentation] 食道癌におけるp53遺伝子変異及びタンパク質発現異常に関与する分子機構2006

    • Author(s)
      江頭明典、森田勝、池田圭介、吉田倫太郎、小嶋綾、西田康二郎、古賀聡、徳永えり子、沖英次、掛地吉弘、前原喜彦
    • Organizer
      第61回日本消化器外科学会定期学術総会
    • Place of Presentation
      横浜
    • Year and Date
      20060713-15
  • [Presentation] Risk Factors for Esophageal Cancer and the Multiple Occurrence of Carcinoma in the Upper Aerodigestive Tract2006

    • Author(s)
      Morita M, Maehara Y
    • Organizer
      16th World Congress of the International Association of Surgeons and Gastroenterologists (and Oncologists)
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      20060525-27
  • [Presentation] アセトアルデヒド皮下投与によるAldh2ノックアウトマウス表皮病変のp53 異常2006

    • Author(s)
      小山倫浩、一瀬豊日、山口哲右、小川真規、木長健、村上朋絵、奈良井理恵、松本明子、市場正良、八嶋康典、尾崎真一、欅田尚樹、村山留美子, 内山巌雄、川本俊弘
    • Organizer
      第79回日本産業衛生学会総会
    • Place of Presentation
      仙台
    • Year and Date
      20060509-12
  • [Presentation] 食道癌の発生における突然変異の蓄積とDNA修復異常に関する研究2006

    • Author(s)
      江頭明典、池田圭介、吉田倫太郎、小嶋綾、西田康二郎、古賀聡、徳永えり子、沖英次、織田信弥、森田勝、掛地吉弘、前原喜彦
    • Organizer
      第106回日本外科学会定期学術集会
    • Place of Presentation
      東京
    • Year and Date
      20060329-31
  • [Book] 有効な症例「どんながんに有効なのか」食道の腫瘍(日本ハイパーサーミア学会編)2008

    • Author(s)
      森田勝、定永倫明、前原喜彦
    • Total Pages
      54-57
    • Publisher
      ハイパーサーミアがん温熱療法ガイドブック
  • [Book] 胃管による食道再建術Digestive Surgery Now No.2食道・胃外科標準手術(上西紀夫編)2008

    • Author(s)
      森田勝、定永倫明、掛地吉弘、前原喜彦
    • Total Pages
      26-43
    • Publisher
      メジカルビュー社、東京
  • [Book] 食道癌に対するsalvage手術の治療成績と妥当性-術前治療別にみた合併症と予後の比較検討-2007

    • Author(s)
      森田勝、安藤幸滋、杉山雅彦、岡田敏子、増田隆伸、吉田倫太郎、今村一郎、大垣吉平、塩谷聡子、芝原幸太郎、沖英次、定永倫明、掛地吉弘、前原喜彦
    • Total Pages
      611-617
    • Publisher
      癌の臨床

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Published: 2010-06-10   Modified: 2016-04-21  

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