The treatment strategy of bronchial dysplasia using a novel autofluorescence imaging bronchovideoscope system and microarray

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18591541
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Chiba University
• Principal Investigator: SHIBUYA Kiyoshi Chiba University, university hospital, Associate professor (20302565)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Makoto Chiba University, Graduate school of medicine, Assistant professor (80312940) ; IYODA Akira Chiba University, university hospital, Assistant professor (10302548) ; YASUFUKU Kazuhiro Chiba University, university hospital, Assistant professor (60372356) ; NAKAJIMA Takahiro Chiba University, university hospital, Assistant professor (20400913) ; SEKI Naohiko Chiba University, Graduate school of medicine, Associate professor (50345013)
• Project Period (FY): 2006 – 2007
• Keywords: AFI / NBI / high resolution bronchovideoscopy / bronchial dysplasia / PET

Research Abstract

Using autofluorescence imaging bronchovideoscope system (AFI) and a high resolution bronchovideoscopy system with narrow band imaging (NBI), we followed up periodically localized bronchial dysplasias and examined for positron emission tomography scanning (PET) with F-18 fluorodeoxyglucose, with the maximum standard uptake value measured. Fifty-three dysplasias mainly with sputum cytology suspicious or positive for malignancy and lung cancer patients were followed up. Of 53 dysplasias, no dysplasias progressed to squamous cell carcinoma. PET identified only two spot in 34 follow up, which are diagnosed as one squamous cell carcinoma and inflammatory tumor. There were no early hilar lung cancers and severe dysplasias only PET findings.

Research Products

• [Journal Article] Cytological findings of pre-invasive bronchial lesions detected by light-induced fluorescence fluorescence endoscopy in a lung cancer screening system. (2007)
  • Author(s): Baba, M. Iyoda, A. Nomoto, Y. Shibuya, K. etc
  • Journal Title: Oncol Rep 17 Pages: 579-583
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 「研究成果報告書概要(欧文)」より
  • Author(s): Baba, M., Iyoda, A., Nomoto, Y., Shibuya, K., etc.
  • Journal Title: Cytological findings of pre-invasive bronchial lesions detected by light-induced fluorescence endoscopy in a lung cancer screening system. Oncol Rep.17 Pages: 579-583
• [Presentation] Recent advance in autofluorescence bronchoscopy and narrow band imaging. (2007)
  • Author(s): Shibuya, K.
  • Organizer: The 2007 Interventional Bronchoscopy Symposium, Kaishiung, Taiwan. Symposium, Invited Special Lecture.
  • Place of Presentation: Taiwan.
  • Year and Date: 2007-07-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] (2007) Recent advance in autofluorescence bronchoscopy and narrow band imaging (2007)
  • Author(s): Shibuya, K.
  • Organizer: The 2007 Interventional Bronchoscopy Symposium, Kaishiung, Taiwan. Symposium, Invited Special Lecture
  • Year and Date: 2007-07-01
  • Description: 「研究成果報告書概要(欧文)」より