2007 Fiscal Year Final Research Report Summary
Intratracheal administration of micro gelatin hydrogel microspheres incorporating basic fibroblast growth factor to treat pulmonary hypertension
| Project/Area Number |
18591545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
MARUI Akira Kyoto University, Cardiovascular Surgery, Assistant Professor (60402856)
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| Co-Investigator(Kenkyū-buntansha) |
IKEDA Tadashi Kyoto University, Cadiovascular Surgery, Associate Professor (40281092)
TABATA Yasuhiko Kyoto University, Institute for FrontierMedhical Sciences, Professor (50211371)
KATAOKA Humiyo Kyoto University, Cadiovascular Surgery, Technical Assistant (40422943)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Pulmonary hypertension / Angiogenesis / Basic fibroblast growth factor |
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| Research Abstract |
Pulmonary hypertension (PH) is a life-threatening disease and alternative strategies are essential for patients with critical PH. We developed a new procedure using micro gelatin hydrogels microspheres incorporating basic fibroblast growth factor (mGHMs/bFGF) for intratracheal administration and evaluated the effect of a single intratracheal administration of mGHMs/bFGF on monocrotaline (MCT)-induced PH rats. In 2006, we developed murine models of progressive and advanced MCT induced PH, and developed mGHMs (diameter : 1-10 η m) which enabled intratracheal administration of bFGF. In 2007, we evaluated the properties of sustained release of bFGF from the mGHMs. In progressive PH model, intratracheal administration of bFGF/mGHMs drastically ameliorated the progression of PH and improved blood gas data. Histologically, the mGHMs/bFGF facilitated angiogenesis and arteriogenesis, and prevented medial hypertrophy. Furthermore, mGHMs/bFGF drastically improved the survival of rats.
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