2007 Fiscal Year Final Research Report Summary
Amelioration of ischemic neuronal by angiotensin receptor control
| Project/Area Number |
18591574
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Akita University |
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Principal Investigator |
SUGAWARA Taku Akita University, Akita University School of Medicine, Lecturer (80241660)
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| Project Period (FY) |
2006 – 2007
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| Keywords | global cerebral ischemia / hippocampal neurons / apoptosis / oxidative stress / superoxide / angiotensin II |
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| Research Abstract |
Excessive superoxide production after cerebral ischemia is known to mediate neuronal injury. Angiotensin II type 1 receptor activation results in production of superoxide, but whether angiotensin II type 1 receptor blockade prevents production of superoxide and subsequent neuronal injury after ischemia remains unclear. Normotensive rats received the angiotensin II type 1 receptor blocker, candesartan or only vehicle before induction of global cerebral ischemia. Approximately 30% of the hippocampal CA1 neurons survived in candesartan-treated animals, whereas only 2% of neurons survived in vehicle-treated animals. Superoxide production was significantly less in these vulnerable neurons in candesartan-treated animals than in vehicle-treated animals. Angiotensin II type 1 receptor may have an essential role in superoxide production and subsequent injury in vulnerable neurons after global cerebral ischemia.
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Research Products
(7 results)
