2007 Fiscal Year Final Research Report Summary
Investigation the roles of LPA producing enzyme ATX in the invasion of glioma
| Project/Area Number |
18591609
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Saitama Medical University (2007)
Teikyo University (2006) |
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Principal Investigator |
FUJIMAKI Takamitsu Saitama Medical University, Faculty of Medicine, Professor (80251255)
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| Co-Investigator(Kenkyū-buntansha) |
MOCHIZUKI Toshihiro Teikyo University, Faculty of Medicine, Lecturer (30302706)
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| Project Period (FY) |
2006 – 2007
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| Keywords | glioma / invasion / LPA / autotaxin |
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| Research Abstract |
Gliomas are malignant brain tumors. The 2-year survival of most malignant form of glioma, glioblastoma, is less than 20%. These tumors are difficult to treat because of the invasiveness of the tumor cells.
Autotaxin (ATX) is a phosphodiesterase and a potential cell motility-stimulating factor. ATX is identical to lysophospholipase D, which produces lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). In this study, we found that ATX transfected mouse gliomas are more motile and infiltrative in vitro. Moreover our result showed that mRNA of ATX is highly expressed in higher grade gliomas whereas that expression is lower in low grade gliomas or other benign brain tumors. A patient with low grade glioma who had high expression of ATX recurred early to show the malignant nature of the tumor.
These results suggest that the ATX contributes to the invasiveness of glioma cells and is correlated with the malignant characteristics of glioma.
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