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2007 Fiscal Year Final Research Report Summary

Investigation the roles of LPA producing enzyme ATX in the invasion of glioma

Research Project

Project/Area Number 18591609
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionSaitama Medical University (2007)
Teikyo University (2006)

Principal Investigator

FUJIMAKI Takamitsu  Saitama Medical University, Faculty of Medicine, Professor (80251255)

Co-Investigator(Kenkyū-buntansha) MOCHIZUKI Toshihiro  Teikyo University, Faculty of Medicine, Lecturer (30302706)
Project Period (FY) 2006 – 2007
Keywordsglioma / invasion / LPA / autotaxin
Research Abstract

Gliomas are malignant brain tumors. The 2-year survival of most malignant form of glioma, glioblastoma, is less than 20%. These tumors are difficult to treat because of the invasiveness of the tumor cells.
Autotaxin (ATX) is a phosphodiesterase and a potential cell motility-stimulating factor. ATX is identical to lysophospholipase D, which produces lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC). In this study, we found that ATX transfected mouse gliomas are more motile and infiltrative in vitro. Moreover our result showed that mRNA of ATX is highly expressed in higher grade gliomas whereas that expression is lower in low grade gliomas or other benign brain tumors. A patient with low grade glioma who had high expression of ATX recurred early to show the malignant nature of the tumor.
These results suggest that the ATX contributes to the invasiveness of glioma cells and is correlated with the malignant characteristics of glioma.

  • Research Products

    (8 results)

All 2007 2006

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Effectiveness of interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent anaplastic astrocyatoma2007

    • Author(s)
      Fujimaki T
    • Journal Title

      Wourld J Surgical Oncol 89

      Pages: 1-5

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effectiveness of interferon-beta and temozolomide combination therapy against temozolomide-refractory recurrent anaplastic astrocyatoma2007

    • Author(s)
      Fujimaki, T
    • Journal Title

      Wourld J Surgical Oncol 89

      Pages: 1-5

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid2006

    • Author(s)
      Kishi Y
    • Journal Title

      J Biol Chem 281

      Pages: 17492-17500

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Congenital gemistocytic astrocytoma in a fetus2006

    • Author(s)
      Nozaki M
    • Journal Title

      Childs Nerv Syst 22

      Pages: 168-171

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid2006

    • Author(s)
      Kishi, Y
    • Journal Title

      J Biol Chem 281

      Pages: 17492-500

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Congenital gemistocytic astrocytoma in a fetus2006

    • Author(s)
      Nozaki, M
    • Journal Title

      Childs Nery Syst 22

      Pages: 168-71

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Autotaxin is overexpressed in glioma and contributes to cell morility of glioblastoma cells2006

    • Author(s)
      Fujimaki T
    • Organizer
      The 11th International Congress of Metastasis Research Society
    • Place of Presentation
      Tokushima
    • Year and Date
      2006-09-05
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Autotaxin is overexpressed in glioma and contributes to cemotility of glioblastoma cells2006

    • Author(s)
      Fujimaki, T
    • Organizer
      The 11th International Congress of Metastasi Research Society
    • Place of Presentation
      Tokushimm JAPAN
    • Year and Date
      2006-09-05
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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