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2007 Fiscal Year Final Research Report Summary

The Mechanisms of cerebral salt wasting syndrome : pathophisiology of hyponatremia following cerebral injury

Research Project

Project/Area Number 18591615
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNihon University

Principal Investigator

MORI Tatsuro  Nihon University, School of Dentistry at MATSUDO, Lecturer (00318437)

Co-Investigator(Kenkyū-buntansha) KATAYMA Yoichi  Nihon University, School of Medicine, Professor (00125048)
KAWAMATA Tatsuro  Nihon University, School of Medicine, Associate Professor (20234122)
Project Period (FY) 2006 – 2007
KeywordsSubarachnoid hemorrhage / Cerebral casospasm / hvoontremia / cerebral salt wasting / itotal blood volume / intracranial pressure
Research Abstract

Introduction : Hyponatremia is a common complication in patients with aneurysmal subarachno id hemorrhage (SAH)These patients demonstrate excessive natriuresis, which decreases the total blood volume through osmotic diuresis and increases the risk of symptomatic cerebral vasospasm. It has been demonstrated that the cerebral salt wasting is the cause of hyponatremia following SAH. However, precise mechanisms underlying SAH-induced hyponatremia remain unclear. The purpose of this study is to evaluate whether the rat SAH model exhibits CSW and determine the physiological parameters following SAH. We induced SAH in rats, and the body weight, serum sodium (Na) levels, Na excretion and serum natiretic peptide were measured.
Methods : Male Wistar rats were used (n=18). SAH was induced using an endovascular puncture method. The mean arterial blood pressure (MABP), intracranial pressure (ICP), and cerebral blood flow (CBF) were continuously monitored. The urine was cumulatively collected for 12 … More hours post SAH, and the urine Na concentration was determined using a spectrophotometer. The serum Na levels, natriuretic peptide (ANP, BNP) and ADH were measured at 12 hours, and 2 and 4 days following SAH induction.
Results : The body weight of SAH rats significantly decreased compared to the sham. The baseline ICP level was 3.5±2.6 mmHg, and was increased to 67.4+17.6 mmHg immediately following the SAH induction. The CBF decreased rapidly and gradually recovered up to 70-80% of the baseline. The urine volume and the total Na excretion significantly increased as comparison to the sham (P<0.05). The serum Na level was significantly decreased at 4 days following SAH (P<0.05). The ANP concentration was significantly decreased in SAH rats (P<0.05), however, the BNP concentration did not change.
Conclusions : The present results demonstrate that the SAH-induced endovascular puncture model in rats causes a rapid elevation of ICP and excessive natriuresis. The cause of CSW following SAH was neither ANP nor BNP. Less

  • Research Products

    (8 results)

All 2007 2006

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] Hyponatremia in patients with traumatic brain injury:incidence,mechanism,and response to sodium supplementation or retention therapy with hydrocortisone2007

    • Author(s)
      Moro N, Katayama Y, Mori T, et. al.
    • Journal Title

      Surg Neurol 68

      Pages: 387-393

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] A randomized controlled trial of hydrocortisone against hyponatremia in patients with aneurysmal subarachnoid hemorrhage2007

    • Author(s)
      Katayama Y, Kawamata T, Mori T, Moro N, et. al.
    • Journal Title

      Stroke 38

      Pages: 2373-2375

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Hyponatremia in patients with traumatic brain injury : incidence, mechanism, and response to sodium supplementation or retention therapy with hydrocortisone2007

    • Author(s)
      Moro, N., Katayama, Y., Igarashi, T., Mori T., et. al.
    • Journal Title

      Surg Neurol 68

      Pages: 387-393

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A randomized controlled trial of hydrocortisone against hyponatremia in patients with aneurysmal subarachnoid hemorrhag2007

    • Author(s)
      Katayama, Y., Kawamata, T., Mori, T., Moro, N., et. al.
    • Journal Title

      Stroke 38

      Pages: 2373-2375

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Endovascular puncture modelによるラットくも膜下出血の頭蓋内圧と低Na血症2006

    • Author(s)
      森 達郎、川又 達朗、片山 容一, ら
    • Journal Title

      Progress in Research on Brain Edema and ICP 8巻

      Pages: 5-10

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Intracranial pressure and hyponatremia following subarachnoid hemorrhage using the endovascular puncture model in rats2006

    • Author(s)
      Mori, T., Kawamata, T., Katayama, Y., et. al.
    • Journal Title

      Progress in Research on Brain Edema and ICP 8

      Pages: 5-10

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Rapid elevation of intracranial pressure and hyponatremia following subarachnoid hemorrhage2007

    • Author(s)
      Mori, T.,Kawamata, T., Katayama, Y., et. al.
    • Organizer
      13th International Symposium on Intracranial Pressure and Brain Monitoring : Mechanisms and Treatment
    • Place of Presentation
      San Francisco,U.S.A
    • Year and Date
      20070722-26
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Rapid elevation of intracranial pressure and hyponatremia following subarachnoid hemorrhage2007

    • Author(s)
      Mori T, Kawamata T, Katayama Y., et. al.
    • Organizer
      13th Intemational Symposium on Intracranial Pressure and Brain Monitoring:"Mechanisms and Treatment"
    • Place of Presentation
      San Francisco,U.S.A
    • Year and Date
      2007-07-23
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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