Establishment OfAnti-angiogenic Therapy For Osteosarcoma

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18591637
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Sapporo Medical University
• Principal Investigator: KAYA Mitsunori Sapporo Medical University, MEDICAL SCHOOL, INSTRUCTOR (10398315)
• Co-Investigator(Kenkyū-buntansha): WADA Takuro SAPPORO MEDICAL UNIVERSITY, MEDICAL SCHOOL, ASSOCIATE PROFESSOR (00244369) ; YAMASHITA Toshihiko SAPPORO MEDICAL UNIVERSITY, MEDICAL SCHOOL, PROFESSOR (70244366)
• Project Period (FY): 2006 – 2007
• Keywords: Osteosarcoma / Pulmonary Metastasis / Anti-angingenic Therapy / Dormant

Research Abstract

We have evaluated the effect of anti-angiogenic therapy using endostatin on postoperative progression of pulmonary metastasis in osteosarcoma. Infection of a recombinant adonovirus which encodes endostatin cDNA after primary tumor removal suppressed the postoperative upregulation of systemic angiogenic activity and kept micrometastases dormant, which resulted in the prevention of progression of pulmonary metastasis. Our results indicate that anti-angiogenic therapy using endostatin has the potential to prevent postoperative progression of pulmonary metastasis in osteosarcoma. Although this therapeutic strategy cannot provide a cure for osteosarcoma, it should enable osteosarcoma patients to coexist with dormant pulmonary metastasis, and lead to the improvement of their prognosis.

Research Products

• [Journal Article] Prevention of postoperative progression of pulmonary metastases in osteosarcoa by anti-angiogenic therapy using endostatin (2007)
  • Author(s): Kaya M
  • Journal Title: J Orthop Sci 12 Pages: 562-567
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Prevention of postoperative progression of pulmonary metastases in osteosarcoma by anti-angiogenic therapy using endostatin (2007)
  • Author(s): Kaya, M., Wada, T., Nagoya, S., Yamashita, T
  • Journal Title: J Orthop Sci 12 Pages: 562
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Angiogenesis and osteosarcoma-A new therapeutic strategy for osteosarcoma (2007)
  • Author(s): Kaya M, et. al.
  • Organizer: 13th Annual Connective Tissue Oncology Society Metting
  • Place of Presentation: Seattle
  • Year and Date: 20071201-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Prevention of postoperative progression of pulmonary metastasis in osteosarcoma by anti-angiogenic therapy using endostatin (2007)
  • Author(s): M. Kaya, S. Nagoya, T. Wada, T. Yamashita
  • Organizer: 13ed Annual Connective Tissue Oncology Society Meeting
  • Place of Presentation: Seattle,U S A
  • Year and Date: 20071201-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Prevention of postoperative progression of pulmonary metastasis in osteosarcoma by anti-angiogenic therapy using endostatin (2007)
  • Author(s): Kaya M, et. al.
  • Organizer: 6th Combined Meeting of the Orthopaedic Societies of Australia/New Zealand, Britain, Canada, Europe, Japan, Korea, Taiwan, USA
  • Place of Presentation: Honolulu
  • Year and Date: 20071020-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Prevention of postoperative progression of pulmonary metastasis in osteosarcoma by anti-angiogenic therapy using endostatin (2007)
  • Author(s): Kaya, M., Nagoya, S., Wada, T., Yamashita, T
  • Organizer: 6th Combined Meeting of the Orthopaedic Societies of Australia/New Zealand, Britain, Canada, Europe, Japan, Korea, Taiwan, USA
  • Place of Presentation: Honolulu,U S A
  • Year and Date: 20071020-24
  • Description: 「研究成果報告書概要(欧文)」より