2007 Fiscal Year Final Research Report Summary
The study for the regenerative med nc of articular cartilage using cell sheet techonology
| Project/Area Number |
18591644
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokai University |
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Principal Investigator |
SATO Masato Tokai University, Orthopaedic Surgery, Associate Professor (10056335)
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| Co-Investigator(Kenkyū-buntansha) |
MOCHIDA Joji Tokai University School of Medicine, Orthopaedic Surgery, Professor (50174347)
MITANI Genya Tokai University School of Medicine, Orthopaedic Surgery, Assistant Professor (80307280)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Temperature-responsive culture dish / Cell sheet / Tissue Engineering / Chondrocyte / Partial thickness defect / Articular cartilage |
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| Research Abstract |
Some treatments for full thickness defects of articular cartilage, such as cultured chondrocytes transplantation, have already been done. However, to overcome osteoarthritis, we must further study the partial thickness defect of articular cartilage. It is much more difficult to repair a partial thickness defect because few repairing cells can address such injured sites. We herein show that bioengineered layered chondrocyte sheets using emperature-responsive culture dishes may be a potentially useful treatment for partial thickness defects. We evaluated the property of these sheets using real-time PCR and histological findings, and allografted these sheets to evaluate the effect of treatment using a rabbit partial model. In conclusion, layered chondrocyte sheets were able to maintain the cartilageous phenotype, and could be attached to the sites of cartilage damage and which acted as a barrier to prevent a loss of proteoglycan from these sites and to protect them from catabolic factors in the joint.
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[Journal Article] Effects of growth factors on heparin-carrying polystyrene-coated atelocoll agen scaffold for articular cartilage tissue engineering2007
Author(s)
Sato M, Ishihara M, Ishihara M, Kaneshiro N, Mitani G, Nagai T, Kutsuna T, Asazuma T, Kikuchi M, Mochida J.
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Journal Title
J.Biomed.Mater.Res.Part B, Appl.Biomaterials 84
Pages: 181-188
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] articular chondrocytes sheets for partial thickness cartilage defects utilizing temperature-responsive culture dish2007
Author(s)
Kaneshiro, N., Sato, M., Ishihara, M., Mitani, G., Kikuchi, T., Mochida, J
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Journal Title
European Cells and Materials Cultured 13
Pages: 87-92
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of growth factors on heparin-carrying polystyrene-coated atelocollagen scaffold for articular cartilage tissue engineering2007
Author(s)
Sato, M., Ishihara, M., Ishihara, M., Kaneshiro, N., Mitani, G., Nagai, T., Kutsuna, T., Asazuma, T., Kikuchi, M., Mochida, J
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Journal Title
Journal of biomedical materials research. Part B 83(1)
Pages: 181-188
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Bioengineered chondrocyte sheets may be potentially useful for the treatment of partial thickness defects of articular cartilage2006
Author(s)
Kaneshiro, N., Sato, M., Ishihara, M., Mitani, G., Sakai, H., Mochida, J
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Journal Title
Biochemical and Biophysical Research Communications 349(2)
Pages: 723-731
Description
「研究成果報告書概要(欧文)」より
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[Presentation] [Invited paper] Technologies for articular cartilage regeneration2007
Author(s)
Sato, M., Ishihara, M., Kaneshiro, N., Mitani, G., Nagai, T., Kutsuna, T., Kikuchi, M., Sakai, H., Mochida, J
Organizer
SPIE Photonics West, San Jose
Place of Presentation
USA
Year and Date
20070000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] The use of bioengineered chondrocyte sheets in treating partial thickness defects of articular cartilage2007
Author(s)
Sato, M., Kaneshiro, N., Mitani, G., Nagai, T., Ishihara, M., Kutsuna, T., Sakai, H., Kikuchi, T
Organizer
53rd Annual Meeting of the Orthopaedic Research Society San Diego, California
Place of Presentation
USA
Year and Date
20070000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Cultured ArticularChondrocytes Sheets Using Temperature-Responsive Cultured Dishes2006
Author(s)
Kaneshiro, N., Sato, M., Mitani, G., Nagai, T., Ishihara, M., Sakai, H., Mochida, J
Organizer
6th International Cartilage Repair Society(ICRS) San Diego, California
Place of Presentation
USA
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Potential of Cell Sheet Engineering for Treatment of Partial Thickness Defect of Articular Cartilage2006
Author(s)
Sato, M., Kaneshiro, N., Mitani, G., Nagai, T., Ishihara, M., Sakai, H., Mochida, J
Organizer
World Congress on Tissue Engineering and Regenerative Medicine
Place of Presentation
Pittsburg USA
Year and Date
20060000
Description
「研究成果報告書概要(欧文)」より
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