New DDS for improving joint lubrication and accelerating the restoration of cartilage

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18591672
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Osaka City University
• Principal Investigator: KITANO Toshio Osaka City University, Graduate School of Medicine, Visiting associate professor (50291597)
• Co-Investigator(Kenkyū-buntansha): TERAI Tomihide Osaka City University, Graduate School of Medicine, Lecturer (20382046) ; NOMURA Chizumi Osaka City University, Graduate School of Medicine, Resercher (10382227) ; HASHIMOTO Yusuke Osaka City University, Graduate School of Medicine, Assistant (10382178)
• Project Period (FY): 2006 – 2007
• Keywords: DDS / Articular cartilage / Liposome / Joint lubrication / Intra-artuicular injection / in-vivo

Research Abstract

The purpose of this study is to clarify the effect of new drug delivery system(DDS) in vivo study. This new DDS is liposome build of Lα-dipalmitoylphosphatidylcholine (DPPC) include Hyaluronic acid which would improve the joint lubrication and restore the degenerative or damaged articular cartilage.
Using rabbit's knee joint, our new DDS was injected into the knee joint. One, seven and fourteen days after injection, Concentration of the joint effusion was measured and inflammation sign of synovium and cartilage were inspected.
Concentration of the joint effusion the new DDS injected was two times as that of control. Inflammation sign of synovium and cartilage were not observed in any specimen.
The result of this study is one of the biggest steps to use this for the clinical therapy.