2007 Fiscal Year Final Research Report Summary
Approach to the genetic therapy of neuropathic pain with the lentivirus vector
| Project/Area Number |
18591686
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Tohoku University |
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Principal Investigator |
KATO Masato Tohoku University, Tohoku Univ. Graduate Sc., of Med., PROFESSOR (50169520)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Daizoh Tohoku Univ. Graduate Sch., Of Med., 大学院・医学系研究科, Associate Professor (30205934)
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| Project Period (FY) |
2006 – 2007
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| Keywords | vector / neuropathic pain / gene pain therapy |
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| Research Abstract |
Na 1.8 is an isoform of voltage-gated sodium channel implicated in the pathogenesis of inflammatory and neuropathic pain. Previously, our collaborative researchers described a series of results in which they blocked production of NAV 1.8 utilizing a strategy so called RNA interference. They used a lentivirus that is taken up by cells and expresses the small hairpin RNA to block the production of the voltage-gated sodium channel subtype.
Present research have tried to investigate the above mentioned effect of the off target effect of the RNA interference of NaV 1.8 mRNA on the rat chronic pain model. However, there was a legal issues concerning the transport of the lentivirus vector from the United States to Japan. Therefore, we could not yet harvest enough data to submit the results to international journals, particularly on this specific issue
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