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2008 Fiscal Year Final Research Report

The establishment of strategy for perioperative myocardial protection by intraoperative ultra-short-acting β1 bloctker

Research Project

  • PDF
Project/Area Number 18591707
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionThe University of Tokushima

Principal Investigator

KITAHATA Hiroshi  The University of Tokushima, 大学院・ヘルスバイオサイエンス研究部, 准教授 (60161486)

Co-Investigator(Kenkyū-buntansha) OSHITA Shuzo  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60144945)
KAWAHITO Shinji  徳島大学, 医学部・歯学部附属病院, 講師 (60284296)
Project Period (FY) 2006 – 2008
Keywords心筋保護作用 / β1遮断薬 / 麻酔薬 / ランジオロール / セボフルラン
Research Abstract

短時間作用型β1遮断薬(交感神経の緊張を弱める薬)による心筋保護作用と各種麻酔薬の影響を動物実験と臨床において検討した。短時間作用型β1遮断薬は明らかな心筋保護作用を示したが, この作用は揮発性吸入麻酔薬(ガス麻酔薬の一種類)により部分的に減弱する可能性がある。虚血性心疾患患者においては揮発性吸入麻酔薬を用いた全身麻酔よりも静脈麻酔薬による全身麻酔中に短時間作用型β1遮断薬を静脈内持続投与した方法がより安全であることが示唆された。

  • Research Products

    (13 results)

All 2008 2007 2006

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results)

  • [Journal Article] Low-dose sevoflurane inhalation enhances late cardioprotection from the and-ulcer drug geranylgeranylacetone2008

    • Author(s)
      Kitahata H, Nozaki J, Kawahito S, Tomino T, Oshita S
    • Journal Title

      Anesthesia and Analgesia 107(3)

      Pages: 755-761

    • Peer Reviewed
  • [Journal Article] 生体機能検査による術中モニタリング経食道心エコーによる術中モニタリング2008

    • Author(s)
      北畑洋
    • Journal Title

      臨床病理 56(6)

      Pages: 508-516

    • Peer Reviewed
  • [Journal Article] Two unusual complications associated with cardiopulmonary bypass for pediatric cardiac surgery detected by transesophageal echocardiography after decannulation2008

    • Author(s)
      Nitta K, Kawahito S, Kitahata H, Nozaki J, Katayama T, Oshita S
    • Journal Title

      Paediatric Anaesthesia 18(4)

      Pages: 325-329

    • Peer Reviewed
  • [Journal Article] Intraoperative transesophageal ventricular pacing in pediatric patients2008

    • Author(s)
      Yamanaka A, Kitahata H, Tanaka K, Kawahito S, Oshita S
    • Journal Title

      ournal of Cardiothoracic and Vascular Anesthesia 22(1)

      Pages: 92-94

    • Peer Reviewed
  • [Journal Article] Non-cardiac surgery applications of extracorporeal circulation2007

    • Author(s)
      Kawahito S, Kitahata H, Kitagawa T, Oshita S, Nose Y
    • Journal Title

      he Journal of Medical Investigation 54(3,4)

      Pages: 200-210

    • Peer Reviewed
  • [Journal Article] Differential effects of etomidate and midazolam on vascular adenosine triphosphate-sensitive potassium channels : Isometric tension and patch clamp studies2007

    • Author(s)
      Nakamura A, Kawahito S, Kawano T, Nazari H, Takahashi A, Kitahata H, Nakaya Y, Oshita S
    • Journal Title

      Anesthesiology 106(3)

      Pages: 515-522

    • Peer Reviewed
  • [Presentation] Landiolol produces cardioprotection in patients undergoing off-pump coronary artery bypass surgery2008

    • Author(s)
      Wakamatsu N, Kawahito S, Kitahata H, Gob R, Kohyama A
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2008-10-22
  • [Presentation] Continuous intraoperative blood glucose monitoring and control using the STG-22 closed-loop system2008

    • Author(s)
      Kawahito S, Kitahata H, Nakamura T, Iseki A, Oshita S
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2008-10-20
  • [Presentation] Intensive insulin therapy in patients undergoing living-related liver transplantation2008

    • Author(s)
      akamura T, Kawahito S, Kitahata H, Tomiyama Y, Oshita S
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2008-10-19
  • [Presentation] High-frequency jet ventilation during thoracoscopic sympathectomy for palmar hyperhidrosis2007

    • Author(s)
      Kawahito S, Iseki A, Tomiyama Y, Kitahata H, Oshita S
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      San Francisco, California
    • Year and Date
      2007-10-16
  • [Presentation] Accuracy of pulse oximetry and capnography in children with cyanotic congenital heart disease2006

    • Author(s)
      Nitta K, Kawahito S, Kitahata H, Nozaki J, Oshita S
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Chicago, Illinois
    • Year and Date
      2006-10-18
  • [Presentation] The role of K^+ channels in vasorelaxation induced by hypoxia and the modulator effects of etomidate2006

    • Author(s)
      Kawahito S, Nakamura A, Kitahata H, Nozaki J, Oshita S
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Chicago, Illinois
    • Year and Date
      2006-10-15
  • [Presentation] The involvement of the mitochondrial K_<ATP> channel on heat-shock protein-induced cardioprotection2006

    • Author(s)
      Kitahata H, Nozaki J, Kawahito S, Tomiyama Y, Oshita S
    • Organizer
      The Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Chicago, Illinois
    • Year and Date
      2006-10-15

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Published: 2010-06-10   Modified: 2016-04-21  

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