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2008 Fiscal Year Self-evaluation Report

Research regarding direct actions of perioperative agents on blood vessels of transplantable organs

Research Project

  • PDF
Project/Area Number 18591708
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKyushu University

Principal Investigator

AKATA Takashi  Kyushu University, 大学院・医学研究院・麻酔・蘇生学, 准教授 (10260382)

Project Period (FY) 2006 – 2009
Keywords血管平滑筋薬理学 / 臓器移植 / 周術期
Research Abstract

移植対象臓器血管に対する、現在、周術期に頻用されている種々の揮発性吸入麻酔薬、静脈麻酔薬、血管作動薬、鎮静薬の直接作用とその臨床関連性を検討するとともに、内皮除去実験、種々の薬理学的阻害薬を用いた実験、細胞内Ca^(2+)濃度測定実験、脱膜化実験、ミオシン軽鎖燐酸化量測定実験により、その機序を可能な限り解明することを目的とした基礎研究である。

  • Research Products

    (12 results)

All 2009 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 5 results) Presentation (6 results)

  • [Journal Article] The mechanisms of the direct action of etomidate on vascular reactivity in rat mesenteric resistance arteries2009

    • Author(s)
      Shirozu K, Akata T, Yoshino J, Setoguchi H, Morikawa K, Hoka S
    • Journal Title

      Anesthesia and Analgesia 108

      Pages: 496-507

    • Peer Reviewed
  • [Journal Article] Cellular and molecularmecha nisms regulating vascular tone. Part 1 : basic mechanisms controlling cy tosolic Ca^<2+> concentration and the Ca^<2+>-dependent regulation of vascular tone2007

    • Author(s)
      Akata T
    • Journal Title

      Journal of Anesthesia 21

      Pages: 232-242

    • Peer Reviewed
  • [Journal Article] Cellular and molecular mechanisms regulating vascular tone. Part 2 : regulatory mechanisms modulating Ca^<2+> mobilization and/or myofilament Ca^<2+> sensitivity in vascular smooth muscle cells2007

    • Author(s)
      Akata T
    • Journal Title

      Journal of Anesthesia 21

      Pages: 232-242

    • Peer Reviewed
  • [Journal Article] General anesthetics and vascular smooth muscle : direct actions of general anesthetics on cellular mechanisms regulating vascular tone2007

    • Author(s)
      Akata T
    • Journal Title

      Anesthesiology 106

      Pages: 365-391

    • Peer Reviewed
  • [Journal Article] 抵抗血管におけるのるアドレナリン収縮反応に及ぼす揮発性麻酔薬の影響-加齢、高血圧、糖尿病に伴う変化に注目して-2007

    • Author(s)
      赤田隆, 泉薫, 吉野淳, 白水和宏
    • Journal Title

      日本臨床麻酔麻酔学会誌 27

      Pages: 207-217

    • Peer Reviewed
  • [Journal Article] 揮発性麻酔薬の血管平滑筋細胞への直接作用とその機序2007

    • Author(s)
      赤田隆
    • Journal Title

      臨床麻酔 31

      Pages: 833-844

  • [Presentation] Mechanisms behind contractile response to norepinephrine or KCl in rat small mesenteric arteries2008

    • Author(s)
      Shirozu K, Akata T
    • Organizer
      2008 Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Orlando, U.S.A.
    • Year and Date
      20081018-22
  • [Presentation] Mechanisms behind the action of etomidate on vascular reactivity in isolated mesenteric arteries2008

    • Author(s)
      Shirozu K, Yoshino J, Setoguchi H, Morikawa K, Akata T
    • Organizer
      2008 Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Orlando, U.S.A.
    • Year and Date
      20081018-22
  • [Presentation] Age-related changes in vascular action of general anesthetics in isolatedsmall mesenteric arteries2008

    • Author(s)
      Yoshino J, Shirozu K, Morikawa K, Setoguchi H, Akata T
    • Organizer
      2008 Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      Orlando, U.S.A.
    • Year and Date
      20081018-22
  • [Presentation] Vascular response to volatile anesthetics is altered in small mesenteric arteries from diabetic rats2007

    • Author(s)
      Yoshino J, Shirozu K, Akata T
    • Organizer
      2007 Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      San Francisco, U.S.A.
    • Year and Date
      2007-10-13
  • [Presentation] Endothelial adrenergic receptors involved in norepinephrine-induced contraction in small arteries2007

    • Author(s)
      Yoshino J, Shirozu K, Akata T
    • Organizer
      2007 Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      San Francisco, U.S.A.
    • Year and Date
      2007-10-13
  • [Presentation] Multiple actions of etomidate on contractile response to norepinephrine in small mesenteric arteries2007

    • Author(s)
      Shirozu K, Setoguchi H, Yoshino J, Akata T
    • Organizer
      2007 Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      San Francisco, U.S.A.
    • Year and Date
      2007-10-13

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Published: 2010-06-11   Modified: 2016-04-21  

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