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2007 Fiscal Year Final Research Report Summary

A research of new cerebroprotection method discovered from cross talk among intracerebral compartments

Research Project

Project/Area Number 18591725
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionTokyo Medical University

Principal Investigator

MUROZONO Michihiro  Tokyo Medical University, School of Medicine, Assistant Professor (70276947)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Shohei  Tokyo Medial University, School of Medicine, Assistant Professor (30256250)
Project Period (FY) 2006 – 2007
KeywordsBrain ischemia / P-glycoprotein / blood-brain barrier
Research Abstract

We measured apoptotic factors, cytokines and factors for tissue repair for the evluation of postischemic influence of P-gp by using immunohistochemistry, western blotting, and ELISA this time. In addition ; we investigated how mdrla P-gp existing in brain of normal mice changed compared with that of mdrla knockout mice. In mdrla knockout mice, Bcl-2 was more and bax was less after ischemia than those of wild-type mice significantly.
Therefore, antiapoptosis action strongly worked on the mdrla ko mouse in comparison with wild-type mice on brain ischemia. After transient cerebral ischemia, on wild-type mice p-gp expressed contineously and without decreaseing, so it is possible that p-gp can act as apotosis inducer at the early stage on brain ischemia.
On the other hand, by a combined medication of cyclosporiti A and Ondansetron, damage of cerebral ischemia decreased significantly. From the above, it is suggested that when it uses cerebroprotection agent which depends on P-gp for treatment for cerebral ischemia, it does a cerebroprotection effect effectively to use other materials dependent on P-gp together.

  • Research Products

    (6 results)

All 2007

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] 脳虚血とプロテインキナーゼ2007

    • Author(s)
      松本 晶平
    • Journal Title

      東京医大雑誌 65

      Pages: 4-15

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 第17回医科学フォーラム2007

    • Author(s)
      松本 晶平
    • Journal Title

      東京医大雑誌 65

      Pages: 309-310

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cerebral ischemia and protein kinase2007

    • Author(s)
      Shohei, Matsumoto
    • Journal Title

      The Journal of Tokyo Medical University 65

      Pages: 4-15

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] No. 17 medical science forum2007

    • Author(s)
      Shohei, Matsumoto
    • Journal Title

      The Journal of Tokyo Medical University 65

      Pages: 309-310

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] サイクロスポリンAとオンダンセトロンを併用した場合の脳虚血に対する効果2007

    • Author(s)
      室園 美智博
    • Organizer
      第9回「応用薬理」年会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-09-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Effects for cerebral ischemia on the combined medication which includes ondansetron and cyclosporin A2007

    • Author(s)
      Michhiro, Murozono
    • Organizer
      No. 9 "applied pharmacology" annual meeting symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-09-10
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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