2007 Fiscal Year Final Research Report Summary
Etiology and teratment of acute tubular necrosis on peritubular capillary microcirculation
| Project/Area Number |
18591747
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya University |
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Principal Investigator |
YAMAMOTO Tokunori Nagoya University, Graduate School of Meclicine, Lecturer (20182636)
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| Co-Investigator(Kenkyū-buntansha) |
GOTOH Momokazu Nagoya University, Graduate School of Medicine, professor (10186900)
HATTORI Ryohei Nagoya University, Graduate School of Medicine, associate professor (20324410)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Acute tubular necrosis / PLCVM imaging / Trombomodulin / Oliprinone / Peritubular capillary / Microcirculation / Renal protect |
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| Research Abstract |
We selected from clinical treatment drug with ability of prorecting vascular endthelial cells as treatment drug for acute tubular necrosis. Oliprinone as treatment drug of heart failure and thrombmodulin as treatment drug of disseminated inravascular coagulation were selected from evaluating on peritubular capillary flow of ischemic reperfusion rat model by pencil lens CCD video-microscopy(PLCVM) imaging technique adition to pathological and biochemical examinations resulting in having ability of renal protecting effect. It revealed that these clinical drugs have effect of protecting the microcirculation for rat repaerfusion model as acute tubular necrosis.
Near future, these clinical drugs with effect of renal microcirculatory protect will be used for patients with acute tubular necrosis.
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Author(s)
Wong, MG, Suzuki, Y, Tanifuji, C, Akiba, H, Okumura, K, Sugaya, T, Yamamoto, T, Horikosh, S, Tan, SY, Pollock, C, Tomino, Y
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[Journal Article] Urine human L-FABP is a Potential Biomarker to predict COX-Inhibitor Induced Renal Injury2008
Author(s)
Tanaka, T, Noiri, E, Yamamoto, T, Sugaya, T, Nugishi, K, Maeda, R, Nakamura, K, Portilla, D, Gotoh, M, Fujita, T
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Journal Title
Nephron Experimental 108
Pages: e19-e26
Description
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[Journal Article] Recombinant Human Soluble Thrombomodulin Ameliorates Ischemic Acute Renal Failure2007
Author(s)
Ozaki, T, Anas, C, Maruyama, S, Yamamoto, T, Yasuda, K, Morita, Y, Ito, Y, Gotoh, M, Yuzawa, Y, Matsuo, S
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Journal Title
Nephrol Gial Transpl 5(Epub ahead offprint)
Description
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[Journal Article] Renal L-Type Fatty Acid : Binding Protein in Acute Ischemic Injury2007
Author(s)
Yamamoto, T, Noiri, E, Ono, Y, Doi, K, Negishi, K, Kamijo, A, Kimura, K, Fujita, T, Kinugawa, T, Taniguchi, H, Nakamura, K,Goto, M, Shinozaki, N, Ohshima, S, Sugaya, T
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[Journal Article] Effects of Olprinone, a phosphodiesterase III inhibitor, on Ischemic Acute Renal Failure2007
Author(s)
Arms, C, Ozaki, T, Maruyama, S, Yamamoto, T, Gotoh, M, Ono, Y, Matsuo, S
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Journal Title
Int J Urol 14(3)
Pages: 219-225
Description
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[Journal Article] Effects of calcium channel blockade on angiotensin II-induced peritubular ischemia in rats2006
Author(s)
Kondo, N, Kiyomoto, H, Yamamoto, T, Miyatake, A, Sun, GP, Rahman, M, Hitomi H, Moriwaki, K, Hara, T, Kimura, S, Abe, Y, Kohno, M, Nishiyama, A
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Pages: 1047-1052
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