2009 Fiscal Year Final Research Report
Identification of responsible gene of bone metastasis in prostate cancer and its treatment using a recombinant HSV
| Project/Area Number |
18591778
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
KATSUOKA Yoji Osaka Medical College, 医学部, 教授 (10051757)
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| Co-Investigator(Kenkyū-buntansha) |
AZUMA Haruhito 大阪医科大学, 医学部, 准教授 (40231914)
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| Project Period (FY) |
2006 – 2009
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| Keywords | HSV / 前立腺癌 / PSM / サバイビン / splice variants |
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| Research Abstract |
1) We have been developing the recombinant HSV, which has the promotor region targeted on prostate specific membrane (PSM).
2) We have found that one of the two splice variant of surviving, survivin-Ex3 has a positive, and the other splice variant survivin-2B has a negative correlation with histological grade.
3) We have been developing the recombinant HSV, which has the promotor region targeted on Survivin-Ex3.
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[Journal Article] Conversion of Prostate Cancer from Hormone Independency to Dependency Due to AMACR Inhibition: Involvement of Increased AR Expression and Decreased IGF1 Expression.2009
Author(s)
Takahara K, Azuma H, Sakamoto T, Kiyama S, Inamoto T, Ibuki N, Nishida T, Nomi H, Ubai T, Sagawa N, Katsuoka Y.
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Journal Title
Anticancer Research 29
Pages: 2497-2506
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