2007 Fiscal Year Final Research Report Summary
Elucidation of genetic-environmental interaction and prevention for pregnancy-induced hypertension
| Project/Area Number |
18591789
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
GEN Kobashi National Institute of Radiological Sciences, Research Center for Charged Particle Therapy, Team Leader (60270782)
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| Co-Investigator(Kenkyū-buntansha) |
HATA Akira Chiba University, Graduate School of Medicine, Department of Public Health, Professor (00244541)
MINAKAMI Hisanori Hokkaido University, Graduate School of Medicine, Department of Obstetrics, Professor (40102256)
YAMADA Takahiro Hokkaido University, Graduate School of Medicine, Department of Obstetrics, research associate (20419948)
IWATA Noboru Hiroshima Kokusai University, Faculty of Human Environment, Professor (80203389)
OHTA Kaori National Institute of Radiological Sciences, Research Center for Charged Particle Therapy, Researcher (20421985)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Pregnancv-Induced Hypertension / genotyping / stress / epidemiology / interview / 相互作用 |
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| Research Abstract |
1. To clarify the interactions among the candidate gene polymorphisms for the occurrence of pregnancy-induced hypertension (PIH), we carried out genotyping of some kinds of genes associated with pressor/depressor mechanisms, the blood coagulation system, lipid metabolism, the intravascular system, the placenta. However we found no significant associations between these polymorphisms and PIH, performing subgroup analyses, in terms of genotypes of AGT, NOS3, and prepregnancy by body mass. Further studies should be carried out in terms of other kinds of genes using larger number of subjects in the future.
2. In order to develop a stress checklist for pregnant women to use examinations and interventions, we performed personal interview and focus group interview in obstetrical department. Emesis, body change by pregnancy, health control methods during pregnancy, economical burden, relationship to parents, child care in the near future, etc. were found to be the stress factors of the pregnant women.
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[Journal Article] Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone.2007
Author(s)
Aoyama H, Tago M, Kato N, Toyoda T, Kenjyo M, Hirota S, Shioura H, Inomata T, Kunieda E, Hayakawa K, Nakagawa K, Kobashi G, Shirato H.
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Journal Title
Int J Radiat Oncol Biol Phys 68
Pages: 1388-1395
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Multi-institutional Prospective Randomized Comparison of Stereotactic Radiosurgery plus Upfront Whole Brain Radiation Therapy versus Stereotactic Radiosurgery Alone for the Treatment of Solitary and Multiple Brain Metastases.2006
Author(s)
Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hayakawa K, Katoh N, Kobashi G.
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Journal Title
J AMA 295
Pages: 2483-2491
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 予防医学と疫学研究2006
Author(s)
小橋 元
Organizer
第30回大動物臨床研究会シンポジウム(基調講演)
Place of Presentation
札幌市
Year and Date
2006-11-25
Description
「研究成果報告書概要(和文)」より
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[Presentation] 予防医学と疫学研究2006
Author(s)
小橋 元
Organizer
第11回大動物臨床教育セミナー(基調講演)
Place of Presentation
江別市
Year and Date
2006-05-30
Description
「研究成果報告書概要(和文)」より
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