2009 Fiscal Year Final Research Report
Relationship between sperm fertilizing ability and intracellular signal transduction.
| Project/Area Number |
18591796
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KUBOTA Toshiro Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授 (50126223)
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Tatsuya 東京医科歯科大学, 医歯学総合研究科, 助教 (80376748)
ISIKAWA Tomonori 東京医科歯科大学, 医歯学総合研究科, 助教 (50447489)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMIZU Yasufumi 田園都市レディースクリニック, 不妊センター長 (80242197)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 生殖医学 |
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| Research Abstract |
The baseline and peak fluorescence of the spermatozoa with abnormal morphology was lower when compared with normal spermatozoa. Follicular fluid-induced [Ca^<2+>]i increase of morphologically normal spermatozoa from infertile couples was lower than that of morphologically normal spermatozoa from healthy donors. This study shows that spermatozoa with abnormal morphology have disorders of signal transduction in healthy donors, and normal shaped sperm from infertile patients have disorders of signal transduction comparing that from healthy donors.
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[Journal Article] Methylation of the Calcium Channel-Related Gene, CACNA2D3, Is Frequent and a Poor Prognostic Factor in Gastric Cancer2008
Author(s)
Wanajo A, Sasaki A, Nagasaki H, Shimada S, Otsubo T, Owaki S, 清水康史, Eishi Y, Kojima K, Nakajima Y, Kawano T, Yuasa Y, Akiyama Y
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Journal Title
Gastroenterology 135
Pages: 580-590
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[Remarks] ホームページ等
