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2008 Fiscal Year Final Research Report

New strategy to manage preterm delivery and pregnancy-induced hypertension in view of inflammation

Research Project

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Project/Area Number 18591797
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionUniversity of Toyama

Principal Investigator

SHIOZAKI Arihiro  University of Toyama, 大学病院, 講師 (00235491)

Co-Investigator(Kenkyū-buntansha) 齋藤 滋  富山大学, 大学院・医学薬学研究部, 教授 (30175351)
Project Period (FY) 2006 – 2008
Keywords妊娠高血圧症候群 / 妊娠高血圧腎症 / 早産 / 炎症 / 免疫
Research Abstract

妊娠高血圧腎症(PE)70例において免疫の指標となるTh1/Th2比をフローサイトメトリーで求めた。正常妊娠59例でも同様にTh1/Th2比を求め、正常妊娠の75%タイル値以上をTh1優位、25~75%タイルをTh1/Th2比正常、25%タイル以下をTh2優位と規定した。その結果3群間で臨床症状を比較したところ、重症型の蛋白尿はTh2優位型PEで75%とTh1優位型PEの32.6%に比し有意に高率であり、重度の蛋白尿を呈する症例ではTh2優位型PEが多いことを初めて明らかにした。

  • Research Products

    (32 results)

All 2008 2007 2006

All Journal Article (11 results) (of which Peer Reviewed: 7 results) Presentation (17 results) Book (4 results)

  • [Journal Article] Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion2008

    • Author(s)
      Nakashima A, Shiozaki A, Myojo S, Ito M, Tatematsu M, Sakai M, Takamori Y, Ogawa K, Nagata K, Saito S
    • Journal Title

      Am J Pathol 173(3)

      Pages: 653-64

    • Peer Reviewed
  • [Journal Article] 切迫早産とその取り扱い方.産婦人科治療増刊2008

    • Author(s)
      塩崎有宏、斎藤滋
    • Journal Title

      周産期診療プラクティス 96 Suppl

      Pages: 564-569

  • [Journal Article] 免疫と妊娠高血圧症候群2008

    • Author(s)
      塩崎有宏、斎藤滋
    • Journal Title

      産婦人科の実際 57(1)

      Pages: 23-30

  • [Journal Article] The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy2007

    • Author(s)
      Saito S, Nakashima A, Myojo-Higuma S, Shiozaki A
    • Journal Title

      J Reprod Immunol 77

      Pages: 14-22

    • Peer Reviewed
  • [Journal Article] Sasaki Y, Nakashima A, Shiozaki A. : Inadequate tolerance induction may induce pre-eclampsia2007

    • Author(s)
      Saito S, Sakai M, Sasaki Y, Nakashima A, Shiozaki A
    • Journal Title

      J Reprod Immunol 76(1-2)

      Pages: 30-39

    • Peer Reviewed
  • [Journal Article] Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsia2007

    • Author(s)
      Sasaki Y, Darmochwal-Kolarz D, Suzuki D, Sakai M, Ito M, Shima T, Shiozaki A, Rolinski J, Saito S
    • Journal Title

      Clin Exp Immunol 149(1)

      Pages: 139-45.

    • Peer Reviewed
  • [Journal Article] Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance2007

    • Author(s)
      Saito S, Shiozaki A, Sasaki Y, Nakashima A, Shima T, Ito M
    • Journal Title

      Semin Immunopathol 29

      Pages: 115-122

    • Peer Reviewed
  • [Journal Article] The role of the immune system in preeclampsia2007

    • Author(s)
      Saito S, Shiozaki A, Nakashima A, Sakai M, Sasaki Y
    • Journal Title

      Mol Aspects Med 28(2)

      Pages: 192-209

    • Peer Reviewed
  • [Journal Article] Interleukin-8 and glucose in amniotic fluid, fetal fibronectin in vaginal secretions and preterm labor index based on clinical variables are optimal predictive markers for preterm delivery in patients with intact membranes2007

    • Author(s)
      Yoneda S, Sakai M, Sasaki Y, Shiozaki A, Hidaka T, Saito S
    • Journal Title

      J Obstet Gynecol Res 33

      Pages: 38-44

    • Peer Reviewed
  • [Journal Article] 前回早産妊娠・分娩既往歴に基づくリスク予測と診療のコツ2007

    • Author(s)
      塩崎有宏、斎藤滋
    • Journal Title

      ペリネイタルケア 26

      Pages: 662-667

  • [Journal Article] 子宮内感染-超低出生体重児の予後に影響する出生前の要因2007

    • Author(s)
      伊奈志帆美、酒井正利、塩崎有宏、斎藤滋
    • Journal Title

      周産期医学 37

      Pages: 439-442

  • [Presentation] Th1/Th2比正常型PEの臨床症状2008

    • Author(s)
      塩崎有宏、稲田貢三子、伊藤実香、伊奈志保美、明星須晴、米田哲、斎藤滋
    • Organizer
      第29回日本妊娠高血圧学会
    • Place of Presentation
      福島
    • Year and Date
      20081000
  • [Presentation] Th1/Th2バランスからみた妊娠高血圧腎症の臨床症状2008

    • Author(s)
      塩崎有宏、伊藤実香、米田徳子、立松美樹子、明星須晴、米田哲、斎藤 滋
    • Organizer
      第44回日本周産期・新生児医学会学術講演会
    • Place of Presentation
      横浜
    • Year and Date
      20080700
  • [Presentation] IL-17 in the pathogenesis of preterm labor2008

    • Author(s)
      Ito M, Nakashima A, Ina S, Okabe M, Yoneda S, Shiozaki A, Nikaido T, Saito S
    • Organizer
      Amerian society for reproductive immunology
    • Place of Presentation
      Chicago, USA
    • Year and Date
      20080610-14
  • [Presentation] 周産期免疫 : 常態と病態2妊娠高血圧症候群2008

    • Author(s)
      塩崎有宏、米田哲、斎藤滋
    • Organizer
      日本産婦人科・新生児血液学会シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      20080600
  • [Presentation] Symposium 2, "Preeclampsia" The role of immune system in pre-eclampsia2008

    • Author(s)
      Saito S
    • Organizer
      15^<th> Congress of the federation of Asia and Oceania perinatal societies
    • Place of Presentation
      Nagoya (Invited speaker)
    • Year and Date
      20080522-24
  • [Presentation] Luncheon seminar. Prevention of preterm birth and treatment for women in preterm labor2008

    • Author(s)
      Saito S
    • Organizer
      15^<th> Congress of the federation of Asia and Oceania perinatal societies
    • Place of Presentation
      Nagoya (Invited speaker)
    • Year and Date
      20080522-24
  • [Presentation] Local regulation of uterine lymphocytes in human2007

    • Author(s)
      Saito S
    • Organizer
      14^<th> congress on gestational trophoblastic diseases
    • Place of Presentation
      Fukuoka (Invited Lecture)
    • Year and Date
      20071111-14
  • [Presentation] Clinical management for prevention of preterm birth and fetal inflammatory response syndrome (FIRS)2007

    • Author(s)
      Saito S
    • Organizer
      3^<rd> Congress of Asian society for pediatric research
    • Place of Presentation
      Tokyo (Invited Lecture)
    • Year and Date
      20071006-08
  • [Presentation] 長期間蛋白尿が持続したTh2型妊娠高血圧腎症の1例2007

    • Author(s)
      塩崎有宏、橋本佳子、米田徳子、立松美樹子、伊奈志帆美、稲坂 淳、若杉聡美、米田 哲、斎藤 滋
    • Organizer
      第28回日本妊娠高血圧学会総会・学術集会
    • Place of Presentation
      愛媛
    • Year and Date
      20071000
  • [Presentation] Cervical inflammation is an indicator for treatment to prevent preterm labor2007

    • Author(s)
      Saito S, Sakai M, Shiozaki A, Yoneda S
    • Organizer
      20^th Asian and oceanic congress of obstetircs and gynecology
    • Place of Presentation
      Tokyo (Invited speaker)
    • Year and Date
      20070921-25
  • [Presentation] Regulatory T cells and regulatory NK cells in normal pregnancy and spontaneous abortion cases2007

    • Author(s)
      Saito S
    • Organizer
      5^<th> European congress of reproductive immunology
    • Place of Presentation
      Berlin (Invited Lecture)
    • Year and Date
      20070830-0902
  • [Presentation] Decidual natural killer cell derived granulysin induces apoptosis of extravillous trophoblast in miscarriage2007

    • Author(s)
      Nakashima A, Shiozaki A, Myojo S, Ito M, Tatematsu M, Saito S
    • Organizer
      13^<th> Internation Federation of placental associations meeting 2007
    • Place of Presentation
      Kingston, Canada.
    • Year and Date
      20070817-22
  • [Presentation] Th1型PEとTh2型PEでは臨床経過が異なる2007

    • Author(s)
      塩崎有宏、酒井正利、田畑実香、立松美樹子、佐々木泰、岡田俊則、斎藤 滋
    • Organizer
      第43回日本周産期・新生児医学会総会・学術集会
    • Place of Presentation
      東京
    • Year and Date
      20070700
  • [Presentation] Saito S : The balance between immunostimulation an immunoregulation during pregnancy2007

    • Author(s)
      Saito S
    • Organizer
      10^<th> International congress of reproductive immunology
    • Place of Presentation
      Opatija, Croatia (Invited Lecture)
    • Year and Date
      20070610-14
  • [Presentation] Proportion of peripheral blood and decidual-CD4+CD25brightregulatory T cells and the expression of Toll like receptor on interstitial extravillous trophoblast in pre-eclampsia2007

    • Author(s)
      Ito M, Sasaki Y, Suzuki D, Sakai M, Shima T, Shiozaki A, Saito S, Darmochwal-Kolarz D
    • Organizer
      10^<th> International congress of reproductive immunology
    • Place of Presentation
      Opatija, Croatia
    • Year and Date
      20070610-14
  • [Presentation] Th1型PEとTh2型PEでは臨床経過が異なる2007

    • Author(s)
      塩崎有宏、酒井正利、伊藤実香、立松美樹子、佐々木泰、岡田俊則、斎藤 滋
    • Organizer
      第59回日本産科婦人科学会総会・学術講演会
    • Place of Presentation
      東京(会長賞受賞)
    • Year and Date
      20070400
  • [Presentation] 妊娠高血圧症候群と免疫2006

    • Author(s)
      塩崎有宏、佐々木泰、鈴木大輔、斎藤滋
    • Organizer
      第27回日本妊娠高血圧学会シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2006-10-07
  • [Book] 絨毛膜羊膜炎の検査, 周産期医学増刊 周産期臨床検査のポイント2008

    • Author(s)
      塩崎有宏、斎藤滋
    • Total Pages
      200-206
    • Publisher
      東京医学社
  • [Book] 妊娠の生理.産婦人科学テキスト2008

    • Author(s)
      塩崎有宏、酒井正利、斎藤滋
    • Total Pages
      380-420
    • Publisher
      中外医学社
  • [Book] ベットサイドで役立つ30症例2007

    • Author(s)
      塩崎有宏、酒井正利、斎藤滋、金芳堂、佐川典正、小西郁生、杉野法広
    • Total Pages
      8-15
    • Publisher
      プライマリケア産婦人科
  • [Book] 最新の知見と取り扱い2007

    • Author(s)
      塩崎有宏、酒井正利、斎藤滋
    • Total Pages
      81-85
    • Publisher
      メジカルビュー社

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Published: 2010-06-10   Modified: 2016-04-21  

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