Study for etiology and pathophysiology of twin-twin transfusion syndrome

2008 Fiscal Year Final Research Report

• Project/Area Number: 18591802
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Yamaguchi University
• Principal Investigator: NAKATA Masahiko Yamaguchi University, 医学部・附属病院, 准教授 (10294646)
• Co-Investigator(Renkei-kenkyūsha): SUMIE Masahiro 山口大学, 医学部・附属病院, 助教 (90335745)
• Project Period (FY): 2006 – 2008
• Keywords: 双胎間輸血症候群 / 一絨毛膜性双胎 / 超音波Doppler 法

Research Abstract

双胎間輸血症候群(twin-twin transfusion syndrome : TTTS)の発症機序と病態の解明を行うため, 超音波Doppler法を用いた胎児・胎盤循環の評価と胎盤における吻合血管の形態評価を行った. その結果, TTTSの供血児では臍帯動脈血流速度波形の拡張期末期途絶や逆流といった異常波形が生命予後と関連し, 病態の重症化の指標として有用であると共に, 動脈-動脈吻合の存在がその重症化に関与している事が明らかとなった.

Research Products

• [Journal Article] Norihiro Sugino Fetoscopic Laser Photocoagulation of Placental Communicating Vessels for Twin Reversed-Arterial Perfusion Sequence (2008)
  • Author(s): Masahiko Nakata, Masahiro Sumie, Susumu Murata, Ichiro Miwa, Masakazu Matsubara
  • Journal Title: J Obstet Gynaecol Res 34(4) Pages: 649-652
  • Peer Reviewed
• [Journal Article] Yuichi Torii Validation of the Quintero's stage III sub-classification for twin-twin transfusion syndrome based on visible or non-visible donor bladder : Characteristic differentiation in their pathophysiology and prognosis (2008)
  • Author(s): Takeshi Murakoshi1, Keisuke Ishii1, Masahiko Nakata, Haruhiko Sago, Satoshi Hayashi, Yuichiro Takahashi, Jun Murotsuki, Mitsuru Matsushita, Takashi Shinno, Hiroo Naruse
  • Journal Title: Ultrasound Obstet Gynecol 32 Pages: 813-818
  • Peer Reviewed
• [Journal Article] A case of monochorionic twin pregnancy complicated with intrauterine single fetal death with successful treatment of intrauterine blood transfusion in the surviving fetus (2007)
  • Author(s): Nakata M, Sumie M, Murata S, Miwa I, Kusaka E, Sugino N.
  • Journal Title: Fetal Diagn Ther 22(1) Pages: 7-9
  • Peer Reviewed
• [Journal Article] Ultrasound assessment prior to laser photocoagulation for twin-twin transfusion syndrome for predicting intrauterine fetal demise after surgery in Japanese patients (2007)
  • Author(s): Ishii K, Hayashi, S, Nakata M, Murakoshi T, Sago H, Tanaka K.
  • Journal Title: Fetal Diagn Ther 22 Pages: 149-54
  • Peer Reviewed
• [Journal Article] 母体・胎児・新生児の心肺機能低下時の反応と対応双胎間輸血症候群(TTTS)をおこした胎児・新生児の循環機能低下時の対応 (2006)
  • Author(s): 中田雅彦, 村田晋, 平野恵美子, 本田理恵, 砂川新平, 三輪一知郎, 住江正大, 前場進治, 杉野法広, 村越毅, 左合治彦, 林聡, 石井桂介, 高橋雄一郎
  • Journal Title: 周産期シンポジウム 24 Pages: 77-82
• [Presentation] Prenatal prediction of outcome following treatment for TTTS (2008)
  • Author(s): M.Nakata, M.Sumie, S.Murata, N.Sugino
  • Organizer: Preand post-operative Doppler assessment can predict fetal outcome in donor twin. Eurofetus symposium : Monoshorionic multiple pregnancies-complications and management options
  • Place of Presentation: Leuven, Belgium
  • Year and Date: 20080516-17
• [Presentation] Sequential laser coagulation of placental communicating vessels for twin-twin transfusion syndrome : a new approach to prevent fetal demise of a donor (2007)
  • Author(s): M. Nakata, T. Muraskoshi, H. Sago, K. Ishii, S. Hayashi, S. Murata, I. Miwa, M. Sumie, N. Sugino
  • Organizer: 17th World Congress on Ultrasound in Obstetrics and Gynecology
  • Place of Presentation: Florence, Italy
  • Year and Date: 20071008-11
• [Presentation] Sequential laser method to improve fetal survival rate in case with abnormal umbilical arterial blood flow in a donor twin. Eurofoetus Symposium (2007)
  • Author(s): Nakata. M, Murakoshi. T
  • Organizer: Twin-to-Twin Transfusion Syndrome in Hamburg
  • Place of Presentation: Germany
  • Year and Date: 20070601-02
• [Presentation] 多胎妊娠の予防と管理双胎間輸血症候群における胎児血行動態に基づいた治療戦略 (2007)
  • Author(s): 中田雅彦
  • Organizer: 第59回日本産科婦人科学会学術講演会
  • Place of Presentation: 京都市
  • Year and Date: 20070414-17
• [Presentation] TTTS に対する胎児鏡下胎盤吻合血管レーザー凝固術(FLP)の今後の課題 (2006)
  • Author(s): 中田雅彦
  • Organizer: 第4回日本胎児治療学会
  • Place of Presentation: 浜松市
  • Year and Date: 20061020-21
• [Book] 一絨毛膜性双胎基本からUpdate まで. 編集 : Japan Fetoscopy Group, 分担執筆 (2007)
  • Publisher: メジカルビュー社