2007 Fiscal Year Final Research Report Summary
Evaluation of fetal blood pressure changes during intrapartum period : basic and clinical researches
| Project/Area Number |
18591805
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
SAMESHIMA Hiroshi University of Miyazaki, Faculty of Medicine, Dept. Ob&GY, Associate Professor (50274775)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAGOE Yasuyuki University of Miyazaki, Faculty of Medicine, Dept. Ob&GY, Assistant Professor (70336311)
KUBOTA Chikara Kagoshima University, Faculty of Agriculture, Dept. Veterinary Medicine, Associate Professor (80420652)
KODAMA Yuki University of Miyazaki, Faculty of Medicine, Dept. Ob&GY, Instructor (30305081)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Electro-mechanical difference / Fetal blood pressure / Fetal heart rate monitoring / non-invasive monitoring / Fetal oxygen saturation |
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| Research Abstract |
Background : From our previous studies, we found that electro-mechanical difference in the fetus is reciprocal to blood pressure changes in utero.
Materials and methods : After IRB approval, we introduced this technique to clinical practice to continuously evaluate fetal blood pressure changes during labor and delivery. After informed consent was obtained from each of the 18 mothers, we placed an electrode on the scalp for fetal electrocardiogram and a SpO2 probe on the cheek, after rupture of the membranes.
Results : Electro-mechanical difference was available in all cases. There was no technique-related abnormality in the conduction of labor. All infants had umbilical arterial pH values > 7.2 and normal neurological outcome. Among the 15 cases with 1-hour or more monitoring duration, the time difference became shortening in 7 cases, extending in 2, and stable in 6. Comparing the shortening and stable groups, incidence of severe variable deceleration was significantly increased in the shortening group, suggesting the reflection of catecholamine release leading possibly to blood pressure increases.
Conclusions : These findings suggest that this technique is promising and practically applicable to clinical use to supplement fetal heart rate monitoring such that to decrease false positive rate of non-reassuring fetal status.
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