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2007 Fiscal Year Final Research Report Summary

The study of diet management, focused on oral supplement of L-arginine plus folic acid for prevention of . preeclampsia

Research Project

Project/Area Number 18591807
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNagoya City University

Principal Investigator

SUZUKI Yoshikatsu  Nagoya City University, graduate School of Medical Sciences, Associate Professor (30254288)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Tamao  Nagoya City University, graduate School of Medical Scipnoas, Research Associate (20405210)
ITOH Takeo  Nagoya City University, graduate School of Medical Sciences, Professor (70159888)
WATANABE Yoshimasa  Nagoya City University, graduate School of Medical Sciences, Assistant Professor (70381803)
Project Period (FY) 2006 – 2007
Keywordspreeclampsoia / endothelial dysfunction / folic acid / L-arginine / prevention
Research Abstract

Preeclampsia, characterized as hypertension and proteinuria threatens to both maternal and fetal life. It causes to increase vascular tone and permeability due to the activation of endothelial function. There are two differ types of the disease. One is dependent on the placental disorder, which is caused by faulty of placentation at early pregnant time. The increases in production of cytokines and superoxide, and insulin resistance might be involved in the pathophysiology with and without placental disorder. Thus, it is important for the management of diet, including sodium and vitamin to treat and prevent it, being similar to metabolic syndrome. In the present study, we investigated whether or not an oral supplementation of L-arginine plus folic acid could improve endothelial dysfunction seen in preeclampsia.
The concentration of serum L-arginine had been increasing advancing gestational ages, however it was reduced in preeclamptic women. Furthermore, flow mediate vasodilatation (FMD), non-invasive evaluation of endothelial function using ultrasound was reduced in both preeclamptic and high risk women (previous preeclampsia). In preeclamptic women, the reduction could not be improved by profuse supplementation of L-arginine 9g plus folic acid 5 mg / day for a several days. In high risk women, the reduction could be improved by the profuse supplement as well as contentious administration of L-arginine lg plus folic acid 0.8mg/day from the second trimester. In conclusion, the supplementation of L-arginine plus folic acid might prevent the endothelial dysfunction seen in preeclampsia.

  • Research Products

    (8 results)

All 2008 2007 2006 Other

All Journal Article (6 results) Presentation (2 results)

  • [Journal Article] 栄養過多と周産期異常2007

    • Author(s)
      山本 珠生, ら
    • Journal Title

      周産期医学 37

      Pages: 571-577

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 血管収縮物質と内皮由来弛緩因子2007

    • Author(s)
      鈴木 佳克, ら
    • Journal Title

      周産期医学 37

      Pages: 1101-1108

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Diet management of perinatal complications2007

    • Author(s)
      Tamao, Yamamoto, et. al.
    • Journal Title

      Perinatal Medicine (Tokyo) 37

      Pages: 571-577

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 妊娠と骨代謝疾患2006

    • Author(s)
      山本 珠生, ら
    • Journal Title

      周産期医学 36

      Pages: 1355-1359

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The bone metabolic disease in pregnant women2006

    • Author(s)
      Tamao, Yamamoto, et. al.
    • Journal Title

      Perinatal Medicine (Tokyo) 36

      Pages: 1355-1359

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The vasoconstrictive agents and endothelial relaxing factors during pregnancy, 2007

    • Author(s)
      Yoshikatsu, Suzuki, et. al.
    • Journal Title

      Perinatal Medicine (Tokyo) 37

      Pages: 1101-1108

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] What are the roles played by peroxynitrite in preeclamptic women2008

    • Author(s)
      Suzuki Y, et. al.
    • Organizer
      Society for Gynecologic Investigation 55th annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2008-03-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] What are the roles played by peroxynitrite in preeclamptic women?2008

    • Author(s)
      Yoshikatsu, Suzuki
    • Organizer
      Society for Gynecologic Investigation Annual Meeting
    • Place of Presentation
      San Diego
    • Year and Date
      2008-03-29
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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