2007 Fiscal Year Final Research Report Summary
Establishment of a sperm fertility evaluation to determine indication of assisted reproductive technology
| Project/Area Number |
18591810
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
YANAGIDA Kaoru International University of Health and Welfare, Hospital, Professor (10182370)
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| Project Period (FY) |
2006 – 2007
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| Keywords | infertility / artificial insemination with husband semen / sperm / in vitro fertilization and embryo transfer / immotile spermatozoa / fertilization abilit / intracytoulasmic sperm iniection / sperm function |
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| Research Abstract |
We have to elucidate the cause to perform the infertility treatment that efficiency is good for. There is the fertilization disorder in the cause that cannot be confirmed now.
We must make a standard of sperm fertility and predict the fertilization disorder beforehand, and it is important to make measures after a fertilization disorder occurred dear. By this study, I examined fertilization results of IVF from semen parameters and a ratio of immotile sperm with an index of sperm-fertilization ability.
[Results] A correlation coefficient with fertility of ratio IVF of immovable survival sperm became -0.41 and did not show correlation. I evaluated fertilization results of IVF about a sperm parameter after sperm preparation method. Fertilization failure was not found in IVF when sperm concentration was more than 10X106/ml, sperm motility was more than 80%, quantity of sperm suspension to add at insemination was equal to or less than 20111 and Kruger's strict criteria was more than 4%. So we choose IVF and carry it out if parameters satisfy these conditions. 52 treatment cycles were performed IVF in this basis. Fertilization failure was not found in these cases. The rate of normal fertilization was 73.1%. Incidence of fertilization failure is high with 15%. Recurrence rate of fertilization failure is more than 30%. Therefore, a case of first time IVF and low fertilization rate case (less than 30%) should be prepared rescue ICSI avoiding complete fertilization failure. Evaluation of fertilization is performed 4.5 hours after insemination in IVF. When all eggs cannot confirm the second polar body, we reevaluate it insemination six hours later. When all eggs cannot confirm fertilization, we perform rescue ICSI.
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[Journal Article] 精子核の質的評価と体外胚発生能2007
Author(s)
片寄, 治男, 高山, 智子, 菅沼, 亮太, 林章, 太郎, 柳田, 薫, 佐藤, 章
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Journal Title
J. Mamm. Ova. Res 24
Pages: 153-160
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] GnRHClinical Report COSにおける GnRHa longprotocolの有用性に関する検討2006
Author(s)
片寄, 治男, 伊藤, 明子, 熊耳, 敦子, 高山, 智子, 菅沼, 亮太, 林章, 太郎, 小宮, ひろみ, 佐藤, 章, 柳田, 薫
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Journal Title
HORMONE FRONTIER IN GYNECOLOGY 13
Pages: 801-806
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 受精障害2007
Author(s)
柳田 薫
Organizer
第10回日本IVF学会
Place of Presentation
横浜市
Year and Date
2007-10-29
Description
「研究成果報告書概要(和文)」より
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[Presentation] 「研究成果報告書概要(欧文)」より2007
Author(s)
菅沼, 亮太, 伊藤, 明子, 熊耳, 敦子, 高山, 智子, 林章, 太郎, 小宮, ひろみ, 片寄, 治男, 柳田, 薫, 柳町, 隆造, 佐藤章
Organizer
日本産科婦人科学会
Year and Date
2007-04-09
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[Presentation] Fertilization Failure in ICSI2006
Author(s)
Kaoru Yanagida, Syouji Hirata, Kazuhiko Hoshi
Organizer
International Symposium "Cell Signaling in Gamete Activation? From Basic Research to ART
Place of Presentation
Tokyo
Year and Date
2006-11-15
Description
「研究成果報告書概要(和文)」より
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[Presentation] 重症男性不妊症例に対する、精子形成障害過程に応じた生殖補助医療(ART)の選択基準、及び、精巣精子AO染色法を用いた精子機能評価法に関する検討ICSIが有効か、TESEが必要か2006
Author(s)
菅沼 亮太, 高野 倫世, 伊藤 明子, 熊耳 敦子, 高山 智子, 林 章太郎, 小宮 ひろみ, 片寄 治男, 柳田 薫, 柳町 隆造, 佐藤 章
Organizer
日本生殖医学会
Place of Presentation
大阪
Year and Date
2006-11-10
Description
「研究成果報告書概要(和文)」より
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[Presentation] 重症男性不妊症例に対する、精子形成障害過程に応じた生殖補助医療(ART)の選択基準、及び、精巣精子AO染色法を用いた精子縫能評価法に関する検討ICSIが有効か、TESEが必要か2006
Author(s)
菅沼, 亮太, 高野, 倫世, 伊藤, 明子, 熊耳, 敦子, 高山, 智子, 林章, 太郎, 小宮, ひろみ, 片寄, 治男, 柳田, 薫, 柳町, 隆造, 佐藤, 章
Organizer
日本生殖医学会
Place of Presentation
大阪
Year and Date
2006-11-10
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 卵活性化法の現状と実際2006
Author(s)
柳田 薫
Organizer
第6回RMB(生殖医学、生物学)シンポジウム
Place of Presentation
東京都
Year and Date
2006-07-08
Description
「研究成果報告書概要(和文)」より
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[Presentation] 卵活性化法の現状と実際2006
Author(s)
柳田, 薫
Organizer
第6回RMB(生殖医学・生物学)シンポジウム
Place of Presentation
東京都
Year and Date
2006-07-08
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 精子核蛋白置換蛋白Transition nuclear protein1,2欠損雄マウスにおける生殖能の検討2006
Author(s)
林 章太郎, 片寄 治男, 熊耳 敦子, 高山 智子, 両角 和人, 呉竹 昭治, 小宮 ひろみ, 佐藤 章, 柳田 薫, 柳町 隆造
Organizer
第119回日本産科婦人科学会東北連合地方部会
Place of Presentation
青森市
Year and Date
2006-06-11
Description
「研究成果報告書概要(和文)」より
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[Presentation] 精子核蛋白置換蛋白Transition nuclear protein 1, 2欠損雄マウスにおける生殖能の検討2006
Author(s)
林章, 太郎, 片寄, 治男, 熊耳, 敦子, 高山, 智子, 両角, 和人, 呉竹, 昭治, 小宮, ひろみ, 佐藤, 章, 柳田, 薫, 柳町, 隆造
Organizer
第119回目本産科婦人科学会東北連合地方部会
Place of Presentation
青森市
Year and Date
2006-06-11
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 胚発生における精子の関与ICSI後胚発生における精子核クロマチンの関与
Author(s)
片寄, 治男, 岩本, 晃明, 柳田, 薫, 高山, 智子, 林章, 太郎, 菅沼, 亮太, 小宮, ひろみ, 佐藤, 章
Organizer
第52回日本生殖医学会
Place of Presentation
京都
Description
「研究成果報告書概要(欧文)」より
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