2009 Fiscal Year Final Research Report
The elucidation of the pathogenesis and a search of the molecular targeted treatment of endometriosis.
| Project/Area Number |
18591844
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
FUJIWARA Hiroyuki Jichi Medical University, 医学部, 准教授 (50316535)
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| Co-Investigator(Kenkyū-buntansha) |
KONNO Ryo 自治医科大学, 医学部, 教授 (70271905)
SUZUKI Mitsuaki 自治医科大学, 医学部, 教授 (50110870)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 子宮内膜症 / 月経困難症 / 慢性炎症性増殖性疾患 |
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| Research Abstract |
One aspect of endometriosis is its chronic inflammatory proliferative disease nature and we believe an immunologic mechanism is associated with the development and extension. From this hypothesis, we carried out several studies to find a treatment target. Using rat endometriosis model, we identified two factors (osteopontin (OPN) and L-selectin) associated with pathogenesis of endometriosis. In clinical studies, we proved the possibility that a leukotriene receptor antagonist which has anti-inflammatory effects was effective in treatment of endometriosis and dysmenorrhea by a prospective, double-blind, randomized, placebo-controlled study.
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[Journal Article] Usefulness of montelukast, a leukotriene receptor antagonist, for dysmenorrheal-A prospective, randomized, placebo-controlled study-.2010
Author(s)
Fujiwara H, Konno R, Netsu S, Odagiri K, Taneichi A, Takamizawa S, Ohwada M, Suzuki M.
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Journal Title
Eur J Obstet Gynecol Reprod Biol. 148
Pages: 195-8
Peer Reviewed
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