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2007 Fiscal Year Final Research Report Summary

New development of superselective arterial infusion for head and neck cancer.

Research Project

Project/Area Number 18591854
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionHokkaido University

Principal Investigator

HOMMA Akihiro  Hokkaido University, Hospital., Lecture (30312359)

Co-Investigator(Kenkyū-buntansha) FURUTA Yasusshi  Hokkaido University, Grad. School of Med., Part-time Lec. (60261301)
FUKUDA Satoshi  Hokkaido University, Grad. School of Med., Professor (20125347)
Project Period (FY) 2006 – 2007
Keywordshead and neck cancer / superselective arterial infusion / prognostic factor / biological factor
Research Abstract

Thirty-five patients with untreated and advanced head and neck cancer were given superselective intra-arterial infusions of cisplatin (100-120 mg/m^2/week) with simultaneous intravenous infusion of thiosulfate to neutralize cisplatin toxicity and conventional extra-beam radiotherapy (RADPLAT) between April 2006 and March 2008. Primary tumor sites included the nasal and paranasal sinuses (n=12), hypopharynx (n=8), oropharynx (n=6), larynx (n=6), oral cavity (n=2), parotidgland (n=1), and external auditory meatus (n=1).
One hundred and eleven patients who were treated in or before 2006 were analyzed. During the median follow-up period of 27 months, the 5-year overall survival and local control of all patients were 69% and 88%, respectively. The local control rate of patients with less than T4b tumor was 91%, and those with T4b was 74%. However, the 5-year overall survival of patients T4b tumor was 49%. And the 5-year overall survival of patients T4b tumor was 49%. And the 5-year overall survival of patients with hypopharyngeal cancer was 49%. It was worse compared with other primary sites.
We analyzed more in detail in hypopharyngeal cancer. Patients with T4b and/or N2c-3 had poor overall survival and local control. In addition, patients with hypopharyngeal cancer located in the midline had poor local control. In addition to clinicopathological factors, biological markers were analyzed to determine whether they were associated with a clinical outcome. Unfortunately, biological markers were not prognostic for overall survival and local control. RADPLAT eradicated cancer cells and showed excellent result. Therefore, it could overcome the low sensitivity to radiotherapy and chemotherapy of the cancer cells.
Another reason may be the insufficient number of cases.
Further studies are needed to establish the prognostic factors, the indications, and long-term outcome of this treatment.

  • Research Products

    (10 results)

All 2008 2006

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] "Watch-and-see" policy for the clinically positive neck in head and neck cancer treated with chemoradiotherapy2006

    • Author(s)
      Homma A
    • Journal Title

      Int J Clin Oncol 11(6)

      Pages: 441-8

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] A Novel Approach to Advanced Carcinoma of the Tongue: Cases Successfully Treated with Combination of Superselective Intra-Arterial Chemotherapy and External/High-Dose-Rate Interstitial Radiotherapy2006

    • Author(s)
      Nishioka T, Homma A
    • Journal Title

      Jpn J Clin Oncol 36(12)

      Pages: 822-6

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Marked and restricted cutaneous pigmentation induced by selective intra-arterial cisplatin infusion2006

    • Author(s)
      Yanagi T, Homma A
    • Journal Title

      J Am Acad Dermatol 54

      Pages: 362-3

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] "Watch-and-see" policy for the clinically positive neck in head and neck cancer treated with chemoradiotherapy2006

    • Author(s)
      Homma A, et. al.
    • Journal Title

      Int J Clin Oncol 11(6)

      Pages: 441-82

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A Novel Approach to Advanced Carcinoma of the Tongue: Cases Successfully Treated with Combination of Superselective Intra-Arterial Chemotherapy and External/High-Dose-Rate Interstitial Radiotherapy2006

    • Author(s)
      Nishioka T, et. al.
    • Journal Title

      Jpn J Clin Oncol 36(12)

      Pages: 822-6

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Marked and restricted cutaneous pigmentation induced by selective intra-arterial cisplatin infusion2006

    • Author(s)
      Yanaei T, et. al.
    • Journal Title

      J Am Acad Dermatol 54

      Pages: 362-3

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Superselective Intra-arterial Infusion of Cisplatin with Concomitant Radiotherapy for Hypopharyngeal Cancer.2008

    • Author(s)
      Homma A, et. al.
    • Organizer
      15th World Congress for Bronchoesophagology
    • Place of Presentation
      Tokyo,Jaoan
    • Year and Date
      20080330-0403
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Superselective Intra-arterial Infusion of Cisplatin with Concomitant Radiontherapy for Hypopharyngeal Cancer2008

    • Author(s)
      本間 明宏
    • Organizer
      15th World Congress for Bronchoesophagology
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-03-31
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] IA chemotherapy-Japanese experience: The Current State of Intra-arterial Chemotherapy for Head and Neck Cancer in Japan2006

    • Author(s)
      本間 明宏
    • Organizer
      International Workshop on Intra-arterial Chemotherapy for Head and Neck Cancer
    • Place of Presentation
      Springfield, Illinois, USA
    • Year and Date
      20060820-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] IA chemotherapy - Japanese experience: The Current State of Intra-arterial Chemotherapy for Head and Neck Cancer in Japan.2006

    • Author(s)
      Homma A. , et. al.
    • Organizer
      International Workshop on Intra-arterial Chemotherapy for Head and Neck Cancer.
    • Place of Presentation
      Springfield, Illinois, USA
    • Year and Date
      20060820-23
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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