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2007 Fiscal Year Final Research Report Summary

Analysis of pathogensis for tonsil-related diseases and basic evidences of usefulness of tonsillectorny

Research Project

Project/Area Number 18591855
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionAsahikawa Medical College

Principal Investigator

BANDOH Nobuyuki  Asahikawa Medical College, Department of otolaryngology and head and neck surgery, Instructor (60312469)

Project Period (FY) 2006 – 2007
KeywordsTonsil-related disease / IgA nephropathy / Pustulosis palmaris et plantaris / Pharyngotonsillitis
Research Abstract

One of the tonsil-Mated disease, IgA nephropathy (IgAN), the most common form of primacy glomerulonephritis, is recognized as one of the tonsil-related diseases since the disease often gets worse after and/or during acute tonsillitis and the disease progression is often prevented by tonsillectomy. Although several reports showed an increase in IgA production of tonsillar mononuclear cells (TMC), its mechanism has not fully clarified yet. Recently, B-cell-activation factor (BAFF), which stimulates B-cell proliferation and immunoglobulin production, was identified. Unmethylated deoxycytidyl-deoxyguanosine oligodeoxynucleotide (CpG-ODN), which is able to mimic the immunostimulatory activity of microbial DNA, is known to be involved in the production of immunoglobulins and some cytokines. In this study, we focused on roles of BAFF and IFN-γ in IgA production of TMC stimulated with CpG-ODN in IgAN patients. Two-color flow cytometric analysis revealed that the intercellular expression of IFN-γ on the T-cells fleshly isolated from tonsils showed significantly higher in IgAN patients than in non-IgAN patients. The spontaneous productions of IgA and IFN-γ of TMC were significantly higher in IgAN patients than in non-IgAN patients. Under stimulation with CpG-ODN, the productions of IgA, BAFF and IFN-γ of TMC were significantly higher in IgAN patients than in non-IgAN patients. The IgA production of TMC stimulated by CpG-ODN was inhibited by the treatment with anti-BAFF antibody and/or anti-IFN-γ antibody. Under stimulation with IFN-γ, the BAFF expression on the CD1c cells and the BAFF production of TMC were significantly higher in IgAN patients than in non-IgAN patients. These data suggest that hyper-immune response to microbial. DNA may be present in IgAN patients and may lead to hyperproduction of BAFF up-regulated by IFN-γ, resulting in hyperproduction of IgA in IgAN patients.

  • Research Products

    (8 results)

All 2008 2007 Other

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Increase in B-cell-activation factor (BAFF) and IFN-gamma productions by tonsillar monon uclear cells stimulated with deoxycytidyl-deoxyguanosine oligodeoxynucleotides (CpG-ODN) in patients with IgA nephropathy2008

    • Author(s)
      Goto T, Bandoh N, et. al.
    • Journal Title

      Clin Immunol 126(3)

      Pages: 25-33

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Selective expansion of T cell receptor (TCR) V beta 6 in tonsillar and peripheral blood T cells and its induction by in vitro stimulation with Haemophilus parainfluenzae in patients with IgA nephropathy2008

    • Author(s)
      Nozawa H, Bandoh N, et. al.
    • Journal Title

      Clin Exp Immunol 151(1)

      Pages: 25-33

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 扁桃病巣疾患の臨床と病態2008

    • Author(s)
      原渕保明、坂東伸幸, 他
    • Journal Title

      耳鼻咽喉科展望 50巻5号

      Pages: 296-305

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Increase in B-cell-activation factor (BAFF) and IFN-gamma productions by tonsillar mononuclear cells stimulated with deoxycytidyl-deoxyguanosine oligodeoxynucleotides (CpG-ODN) in patients with IgA nephropathy.2008

    • Author(s)
      Goto T, Bandoh N, Yoshizaki T, Nozawa H, Takahara M, Ueda S, Hayashi T, Harabuchi Y.
    • Journal Title

      Clin Immunol 126(3)

      Pages: 260-9

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Selective expansion of T cell receptor (TCR) V beta 6 in tonsillar and peripheral blood T cells and its induction by in vitro stimulation with Haemophilus parainfluenzae in patients with IgA nephropathy.2008

    • Author(s)
      Nozawa H, Takahara M, Yoshizaki T, Goto T, Bandoh N, Harabuchi Y.
    • Journal Title

      Clin Exp Immunol 151(1)

      Pages: 25-33

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Clinical and condition of amygdalae disease nest disease2008

    • Author(s)
      Harabuchi Y, Bandoh N, et. al.
    • Journal Title

      Otorhinolaryngology view 50(5)

      Pages: 296-305

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Role of CXCR3 expression in tonsillar T-cells of patients with IgA nephropathy2007

    • Author(s)
      Bandoh N.
    • Organizer
      International Congress of Mucosal Immunology
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20070709-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/oto/

URL: 

Published: 2010-02-04  

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