2007 Fiscal Year Final Research Report Summary
Rho gene expression correlates with tumor invasiveness and metastasis in head and neck cancers
| Project/Area Number |
18591862
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
MINETA Hiroyuki Hamamatsu University School of Medicine, 医学部, Professor (40190714)
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| Co-Investigator(Kenkyū-buntansha) |
MIURA Katsutoshi Hamamatu University school of Medicine, 医学部, Professor (20173974)
OKAMURA Jun Hamamatu University of Medicine, Hospital, Resident (00402305)
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| Project Period (FY) |
2006 – 2007
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| Keywords | head and meek cancer / rho / endostatin |
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| Research Abstract |
The research of tumor invasiveness by Snail or Twist shows the mechanism of signal transduction in tumor development. However, few information has been revealed endothelial-messenchymal transduction.
We showed that rho gene was associated with tumor progression in head and neck squamous cell carcinomas, but not associated with prognosis. And we reported that endogenous endostatin expression correlated with tumor size and p53 expression, but not lymph node status and prognosis, and that high endostatin expression correlated with high microvessel density in primary tumors. Endogenous endostatin which may be upregulated by p53 gene does not represent antiangiogenic phenotype of the primary tumors.
endostatin expression correlated with tumor size and p53 expression, but not lymph node status and prognosis, and that high endostatin expression correlated with high microvessel density in primary tumors. Endogenous endostatin which my be upregulated by p53 gene does not represent antiangiogenic phenotype of the primary tumors.
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