• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2007 Fiscal Year Final Research Report Summary

The relation ofATM in the pathology of retinal and chuoidal neovascularization

Research Project

Project/Area Number 18591933
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

INOUE Makoto  Keio University, School of Medicine, assistant professor (20232556)

Co-Investigator(Kenkyū-buntansha) ISHIDA Susumu  Keio University, School of Medicine, assistant professor (10245558)
Project Period (FY) 2006 – 2007
Keywordsangiogenesis / oxidative stress / VEGF / Retina / Age-related macula degeneration
Research Abstract

The ATM gene provides instructions for making a protein that is located primarily in the nucleus of cells, where it helps control the rate at which cells grow and divide. The ATM protein also assists cells in recognizing damaged or broken strands of DNA. Moreover, the appearance of disease of a malignant tumor such as the lymphoid tumors is admitted in high frequency in the patients of ataxia telangiectasia, and gene mutation and loss of Atm are found in the tumor cells. The function of DNA restoration is injured in the tumor cell that has the Atm gene mutation, and it is suggested that the function loss of the ATM relate to carcinogenesis.
Recently, it is shown that the self-renewal capacity of hematopoietic stem cells depends on ATM-mediated inhibition of oxidative stress in ATM KO mice. (Ito K, et al. Nature 2004, 997-1002). Then, we hypothesize that the background for the diabetic retinopathy such as the oxidative stresses can be improved by properly controlling the ATM.
By perfusion-labeling method with fluorescein-isothiocyanate (FITC)-coupled concanavalin A lectin (Con A), we show that the number of adherent leukocytes was significantly higher in Atm+/- mice and Atm-/- mice than in C57BL/6 normal mice. Moreover, the number of adherent leukocytes doesn't change with making the STZ diabetic model. The oxidative stress is known to be accelerated in the STZ diabetic model mice, and so these results imply that the accelerated stress is influenced by ATM.

  • Research Products

    (4 results)

All 2007

All Journal Article (4 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Two-step oblique incision during 25-gauge vitrectomy reduces incidence of postoperative hypotony2007

    • Author(s)
      Inoue M, et. al.
    • Journal Title

      Clin Experiment Ophthalmol 8

      Pages: 693-696

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 25-gauge cannula system with microvitreoretinal blade trocar.2007

    • Author(s)
      Inoue M, et. al.
    • Journal Title

      Am J Ophthalmol 2

      Pages: 302-304

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Two-step oblique incision during 25-gauge vitrectomy reduces incidence of postoperative hyp otony2007

    • Author(s)
      Inoue, M, et. al.
    • Journal Title

      Clin Experiment Ophthalmol 8

      Pages: 693-696

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 25-gauge cannula system with microvitreoretinal blade trocar2007

    • Author(s)
      Inoue, M, et. al.
    • Journal Title

      Am J Ophthalmol 2

      Pages: 302-304

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2010-02-04  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi