Expression analysis of molecules specific for development of autoimmune uveitis

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 18591935
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Tokyo Medical University
• Principal Investigator: TAKEUCHI Maseru Tokyo Medical University, Ophthalmology, MD, PhD Associated Professor (40260939)
• Project Period (FY): 2006 – 2007
• Keywords: Behcet's disease / uveitis / autoimmune disease / microarrav / chemokine / experimental autoimmune uveitis

Research Abstract

In this study, we examined molecules which are increasing their gene expression in peripheral T cells of mice developing experimental autoimmune uveoretinitis (EAU) by immunization with interphotoreceptor retinoid-binding protein (IRBP).
As the results, mRNA expression which increased more than 5 fold on both 7 and 14 days after immunization were cytokines associated with Th17 cells except for those of Thl cells, implicating that Th17 cells were also involved in the occurrence of EAU.
Subsequently, we collected peripheral T cells from behcet's patient with uveitis, stimulated them with S-Ag and IRBP, and measured production of IFN-g, IL-17, IL-6, TNFa, and IL-10. Unexpectedly, positive rates of T cells reactive for S-Ag and IRBP were statistically not different between Behcet's patients and healthy controls. However, the amounts of several produced cytokines were more in Behcet's patients than in healthy controls, in which Behcet's patients produced more IFN-g, IL-17, and IL-6 by stimulation with IRBP, and more IFN-g and TNFa by stimulation with S-Ag than those of healthy controls.
We continue this series of experiments, also using peripheral T cells obtained from Behcet's patients who have not had uveitis, sarcoidosis patients, and VKH patients, et. al.

Research Products

• [Journal Article] Circulating neutrophils in Behcet disease is resistant for apoptotic cell death in the remission phase of uveitis (2008)
  • Author(s): Fujimori K, Oh-I K, Takeuchi M, Yamakawa N, Hattori T, Kezuka T, Keino H, Suzuki J, Goto H, Sakai JI, Usui M.
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology 246 Pages: 285-90
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Functional Expression of B7H1 on Retinal Pigment Epithelial Cells (2008)
  • Author(s): Usui Y, Okunuki Y, Hattori T, Kezuka T, Ebihara N, Sugita S, Usui M, Goto H, Takeuchi M.
  • Journal Title: Experimental Eye Research 86 Pages: 52-59
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Proteomic surveillance of retinal autoantigens in endogenous uveitis:Implication of esterse D and brain type creatine kinase as novel autoantigens (2008)
  • Author(s): Okunuki Y, Usui Y, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Sakai J, Usui M, Nishioka K, Kato T, Takeuchi M.
  • Journal Title: Molecular Vision
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Circulating neutrophils in Behcet disease is resistant for apoptotic cell death in the remission phase of uveitis (2008)
  • Author(s): Fujimori, K, Oh-I, K, Takeuchi, M, Yamakawa, N, Hattori, T, Kezuka, T, Keino, H, Suzuki, J, Goto, H, Sakai, JI, Usui, M
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 246 Pages: 285-290
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional Expression of B7H1 on Retinal Pigment Epithelial Cells. (2008)
  • Author(s): Usui, Y, Okunuki, Y, Hattori, T, Kezuka, T, Ebihara, N, Sugita, S, Usui, M, Goto, H, Takeuchi, M
  • Journal Title: Exp Eye Res 86 Pages: 52-59
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Proteomic surveillance of retinal autoantigens in endogenous uveitis : Implication of esterseD and brain type creatine knase as novel autoantigens (2008)
  • Author(s): Okunuki, Y, Usui, Y, Kezuka, T, Hattori, T, Masuko, K, Nakamura, H, Yudoh, K, Sakai, J, Usui, M, Nishioka, K, Kato, T, Takeuchi, M
  • Journal Title: Mol Vis (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Blockade of the OX40 ligand prolongs corneal allograft survival (2007)
  • Author(s): Hattori T, Usui Y, Okunuki Y, Sonoda Y, Usui M, Takada E, Mizuguchi J, Yagita H, Okumura K, Akiba H, Takeuchi M.
  • Journal Title: European Journal of Immunology 37 Pages: 3597-3604
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Proteomic surveillance of autoimmunity in Behcet's disease with uveitis:selenium binding protein is a novel autoantigen in Behcet's disease (2007)
  • Author(s): Okunuki Y, Usui Y, Takeuchi M, Kezuka T, Hattori T, Masuko K, Nakamura H, Yudoh K, Usui M, Nishioka K, Kato T.
  • Journal Title: Experimental Eye Research 84 Pages: 823-831
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Thymus-Derived CD4+ CD25+ T Cells Suppress the Development of Murine Allergic Conjunctivitis (2007)
  • Author(s): Sumi T, Fukushima A, Fukuda K, Kumagai N, Nishida T, Takeuchi M, Taguchi O, Ueno H.
  • Journal Title: International archives of allergy and applied immunology 143 Pages: 276-281
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Intravitreal injection of Tacrolimus (FK506) suppresses ongoing experimental autoimmune uveoretinitis in Rats (2007)
  • Author(s): Oh-I K, Keino H, Goto H, Yamakawa N, Murase K, Usai Y, Kezuka T, Sakai J, Takeuchi M, Usui M.
  • Journal Title: British Journal of Ophthalmology 91 Pages: 237-42
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Supplementation of CD4+CD25+ regulatory T cells suppresses experimental autoimmune uveoretinitis (2007)
  • Author(s): Keino H, Takeuchi M, Usui Y, Hattori T, Yamakawa N, Kezuka T, Sakai JI, Usui M.
  • Journal Title: British Journal of Ophthalmology 91 Pages: 105-110
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Roles of CD4+ CD25+ T cells in the development of experimental murine allergic conjunctivitis (2007)
  • Author(s): Fukushima A, Yamaguchi T, Sumi T, Fukuda K, Kumagai N, Nishida T, Takeuchi M, Taguchi O, Ueno H.
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology 245 Pages: 705-14
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Blockade of the OX40ligand prolongs corneal allograft survival. (2007)
  • Author(s): Hattori, T, Usui, Y, Okunuki, Y, Sonoda, Y, Usui, M, Takada, E, Mizuguchi, J, Yagita, H, Okumura, K, Akiba, H, Takeuchi, M
  • Journal Title: lEur J Immunol 37 Pages: 3597-3604
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Proteomic surveillance of autoimmunity in Behcet's disease with uveitis : selenium binding protein is a novel autoantigen in Behcet's disease (2007)
  • Author(s): Okunuki, Y, Usui, Y, Takeuchi, M, Kezuka, T, Hattori, T, Masuko, K, Nakamura, H, Yudoh, K, Usui, M, Nishioka, K, Kato, T
  • Journal Title: Exp Eye Res 84 Pages: 823-31
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Thymus-Derived CD4+ CD25+ T Cells Suppress the Development of Murine Allergic Conjunctivitis (2007)
  • Author(s): Sumi, T, Fukushima, A, Fukuda, K, Kumagai, N, Nishida, T, Takeuchi, M, Taguchi, O, Ueno, H
  • Journal Title: Int Arch Allergy Immunol 143 Pages: 276-281
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Intravitreal injection of Tacrolimus(FK506) suppresses ongoing experimental autoimmune uveoretinitis in Rats (2007)
  • Author(s): Oh-i, K, Keino, H, Goto, H, Yamakawa, N, Murase, K, Usui, Y, Kezuka, T, Sakai, J, Takeuchi, M, Usui, M
  • Journal Title: Br J Ophthalmol 91 Pages: 237-42
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Supplementation of CD4+CD25+ regulatory T cells suppresses experimental autoimmune uveoretinitis (2007)
  • Author(s): Keino, H, Takeuchi, M, Usui, Y, Hattori, T, Yamakawa, N, Kezuka, T, Sakai, JI, Usui, M
  • Journal Title: Br J Ophthalmol 91 Pages: 105-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Roles of CD4+CD25+ T cells in the development of experimental murine allergic conjunctivitis (2007)
  • Author(s): Fukushima, A, Yamaguchi, T, Sumi, T, Fukuda, K, Kumagai, N, Nishida, T, Takeuchi, M, Taguchi, O, Ueno, H
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 245 Pages: 705-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The role of the ICOS/B7RP-1T cell costimulatory pathway in murine experimental autoimmune uveoretinitis (2006)
  • Author(s): Usui Y, Akiba H, Takeuchi M, Kezuka T, Takeuchi A, Hattori T, Okunuki Y, Yamazaki T, Yagita H, Usui M, Okumura K
  • Journal Title: Eur J Immunol 36 Pages: 3071-81
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Clinical evaluation of blue-light blocker foldable acrylic IOL(HMY) (2006)
  • Author(s): Hibino T, Shimomura Y, Matsumoto C, Fukuda M, Uno N, Usui M, Takeuchi M, Asatani T, Minoda H
  • Journal Title: Ann Ophthalmol(Skokie) 38 Pages: 311-6
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Expression of costimulatory molecules on human retinoblastoma cells Y-79:functional expression of CD40 and B7H1 (2006)
  • Author(s): Usui Y, Okunuki Y, Hattori T, Takeuchi M, Kezuka T, Goto H, Usui M
  • Journal Title: Invest Ophthalmol Vis Sci 47 Pages: 4607-13
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Possibility of inducing anterioe chamber-associated immune deviation by TGF-beta2 treatment of monocytes isolated from Behcet's patients (2006)
  • Author(s): Takeuchi M, Keino H, Suzuki J, Usui Y, Hattori T, Takeuchi A, Oh-I K, Okunuki Y, Kezuka T, Usui M
  • Journal Title: Exp Eye Res 83 Pages: 981-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Frequent immune response to a melanocyte-specific protein KU-MEL-1 in patients with Vogt-Koyanagi-Harada disease (2006)
  • Author(s): Otani S, Sakurai T, Yamamoto K, Fujita T, Matsuzaki Y, Goto Y, Ando Y, Suzuki S, Usui M, Takeuchi M, Kawakami Y
  • Journal Title: Br J Ophthalmol 90 Pages: 773-7
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Elevated Serum Levels of CXCL9/Monokine Induced by Interferon-{gamma} and CXCL10/Interferon-{gamma}-Inducible Protein-10 in Ocular Sarcoidosis (2006)
  • Author(s): Takeuchi M, Oh-I K, Suzuki J, Hattori T, Takeuchi A, Okunuki Y, Usui Y, Usui M
  • Journal Title: Invest Ophthalmol Vis Sci 47 Pages: 1063-8
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Alpha-internexin as a corneal autoantigen in spontaneous autoimmune keratitis mouse model (2006)
  • Author(s): Hattori T, Takeuchi M, Ohno K, Ogawara M, Asatani T, Muramatsu R, Inagaki M, Usui M, Taguchi O
  • Journal Title: Invest Ophthalmol Vis Sci 47 Pages: 249-55
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+T regulatory cells (2006)
  • Author(s): Keino H, Takeuchi M, Kezuka T, Hattori T, Usui M, Taguchi O, Streilein JW
  • Journal Title: Invest Ophthalmol Vis Sci 47 Pages: 1047-55
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The role of the ICOSB7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis (2006)
  • Author(s): Usui Y, Akiba H, Takeuchi M, Kezuka T, Takeuchi A, Hattori T, Okunuki Y, Yamazaki T, Yagita H, Usui M, Okumura K
  • Journal Title: Eur J Immuno 36 Pages: 3071-81
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Clinical evaluation of blue-light blocker foldable acrylic IOL(HMY) (2006)
  • Author(s): Hibino, T, Shimomura, Y, Matsumoto, C, Fukuda, M, Uno, N, Usui, M, Takeuchi, M, Asatani, T, Minoda, H
  • Journal Title: Ann Ophthalmol(Skokie) 38 Pages: 311-6
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Expression of costimulatory molecules on human retinoblastoma cells Y-79 : functional expression of CD40 and B7H1 (2006)
  • Author(s): Usui, Y, Okunuki, Y, Hattori, T, Takeuchi, M, Kezuka, T, Goto, H, Usui, M
  • Journal Title: Invest Ophthalmol Vis Sci 47 Pages: 4607-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Possibility of inducing anterior chamber-associated immune deviation by TGF-beta2 treatment of monocytes isolated from Behcet's patients (2006)
  • Author(s): Takeuchi, M, Keino, H, Suzuki, J, Usui, Y, Hattori, T, Takeuchi, A, Oh-I, K, Okunuki, Y, Kezuka, T, Usui, M
  • Journal Title: IExp Eye Res 83 Pages: 981-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Frequent immune response to a melanocyte-specific protein KU-MEL-1 in patients with Vogt-Koyanagi-Harada disease (2006)
  • Author(s): Otani, S, Sakurai, T, Yamamoto, K, Fujita, T, Matsuzaki, Y, Goto, Y, Ando, Y, Suzuki, S, Usui, M, Takeuchi, M, Kawakami, Y
  • Journal Title: Br J Ophthalmol 90 Pages: 773-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Elevated Serum Levels of CXCL9/Monokine Induced by Interferon-{gamma} and CXCL10/Interferon-{gamma}-Inducible Protein-10 in Ocular Sarcoidosis (2006)
  • Author(s): Takeuchi, M, Oh-I, K, Suzuki, J, Hattori, T, Takeuchi, A, Okunuki, Y, Usui, Y, Usui, M
  • Journal Title: Invest Ophthalmol Vis Sci 47 Pages: 1063-8
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Alpha-internexin as a corneal autoantigen in spontaneous autoimmune keratitis mouse model (2006)
  • Author(s): Hattori, T, Takeuchi, M, Ohno, K, Ogawara, M, Asatani, T, Muramatsu, R, Inagaki, M, Usui, M, Taguch, i O
  • Journal Title: Invest Ophthalmol Vis Sci 47 Pages: 249-55
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induction of eye-derived tolerance does not depend on naturally occurring CD4+CD25+ T regulatory cells (2006)
  • Author(s): Keino, H, Takeuchi, M, Kezuka, T, Hattori, T, Usui, M, Taguchi, O, Streilein, JW
  • Journal Title: Invest Ophthalmol Vis Sci 47 Pages: 1047-55
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] マイクロペリメーター1(MP-1)によるぶどう膜炎患者の視機能評価 (2007)
  • Author(s): 竹内 大, 奥貫 陽子, 臼井 嘉彦, 毛塚 剛司, 坂井 潤一, 岩崎 琢也, 後藤 浩
  • Organizer: 第61回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 20071011-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 癬に伴うぶどう膜炎の検討 (2007)
  • Author(s): 奥貫 陽子, 毛塚 剛司, 臼井 嘉彦, 竹内 大, 坂井 潤一, 後藤 浩乾
  • Organizer: 第61回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 20071011-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Proteomic Surveillance of Retinal Autoantigens in Endogenous Uveoretinitis:Implication of EsteraseD and Brain Type Creatine Kinase as Novel Autoantigens (2007)
  • Author(s): Y.Okunuki, Y.Usui, T.Hattori, T.Kezuka, K.Nishioka, T.Kato, M.Takeuchi, M.Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)Fort Lauderdale
  • Place of Presentation: 米国
  • Year and Date: 20070506-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Monokine Induced by Interferon γ (Mig)(CXCL9) in the Vitreous of Patients With Proliferative Diabetic Retinopathy (2007)
  • Author(s): T.Tsuboi, Y.Usui, Y.Okunuki, M.Takeuchi, H.Minoda, T.Hattori, T.Iwasaki, H.Goto, M.Usui, Y.Wakabayashi
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)Fort Lauderdale
  • Place of Presentation: 米国
  • Year and Date: 20070506-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulatory Dendritic Cells Suppress Experimental Autoimmune Uveoretinitis in Mice (2007)
  • Author(s): Y.Usui, M.Takeuchi, T.Hattori, Y.Okunuki, T.Kezuka, K.Nagasawa, M.Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)Fort Lauderdale
  • Place of Presentation: 米国
  • Year and Date: 20070506-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Human Iris Pigment Epithelial (hIPE) Cells Possess a Capacity to Modulate T Cell Activation (2007)
  • Author(s): T.Hattori, T.Kezuka, Y.Usui, M.Takeuchi, Y.Okunuki, M.Kurita, R.Yamashita, M.Haneda, S.Shirato, M.Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)Fort Lauderdale
  • Place of Presentation: 米国
  • Year and Date: 20070506-10
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Proteomic Surveillance of Retinal Autoantigens in Endogenous Uveoretinitis : Implication of EsteraseD and Brain Type Creatine Kinase as Novel Autoantigens (2007)
  • Author(s): Y., Okunuki, Y., Usui, T., Hattori, T., Kezuka, K., Nishioka, T., Kato, M., Takeuchi, M., Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO) Fort.Lauderdale
  • Place of Presentation: U.S.A
  • Year and Date: 20070506-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Wakabayashi, Monokine Induced by Interferon y(Mig)(CXCL9) in the Vitreous of Patients With Proliferative Diabetic Retinopathv (2007)
  • Author(s): T., Tsuboi, Y., Usui, Y., Okunuki, M., Takeuchi, H., Minoda, T., Hattori, T., Iwasaki, H., Goto, M., Usui, Y
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO) Fort Lauderdale
  • Place of Presentation: U.S.A
  • Year and Date: 20070506-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulatory Dendritic Cells Suppress Experimental Autoimmune Uveoretinitis in Mice (2007)
  • Author(s): Y., Usui, M., Takeuchi, T., Hattori, Y., Okunuki, T., Kezuka, K., Nagasawa, M., Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO) Fort Lauderdale
  • Place of Presentation: U.S.A
  • Year and Date: 20070506-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Human Iris Pigment Epithelial(hIPE) Cells Possess a (2007)
  • Author(s): T., Hattori, T., Kezuka, Y., Usui, M., Takeuchi, Y., Okunuki, M., Kurita, R., Yamashita, M., Haneda, S., Shirato, M., Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO) Fort Lauderdale
  • Place of Presentation: U.S.A
  • Year and Date: 20070506-10
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 実験的自己免疫性ぶどう膜網膜炎における肥満細胞の役割 (2007)
  • Author(s): 奥貫 陽子, 白井 嘉彦, 竹内 大, 毛塚 剛司, 坂井 潤一, 後藤 浩
  • Organizer: 第41回日本眼炎症学会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ヒト虹彩色素上皮細胞の免疫抑制効果 (2007)
  • Author(s): 服部 貴明, 毛塚 剛司, 臼井 嘉彦, 竹内 大, 栗田 正憲, 山下 理恵子, 羽田 麻衣, 白土 城照, 後藤 浩
  • Organizer: 第41回日本眼炎症学会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] タクロリムス眼内注入による実験的ぶどう膜炎における神経保護関連遺伝子の発現上昇 (2007)
  • Author(s): 大井 桂子, 慶野 博, 山川 直之, 竹内 大, 臼井 正彦, 後藤 浩
  • Organizer: 第41回日本眼炎症学会
  • Place of Presentation: 東京
  • Year and Date: 2007-07-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 実験的アレルギー性結膜炎におけるCD4/CD25陽性細胞の抑制的関与 (2007)
  • Author(s): 角 環, 福島 敦樹, 福田 憲, 熊谷 直樹, 西田 輝夫, 田口 修, 竹内 大, 上野 脩幸
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 内因性ぶどう膜炎による網膜組織障害で二次的に誘導される抗網膜抗体標的抗原の網羅的同定 (2007)
  • Author(s): 奥貫 陽子, 臼井 嘉彦, 服部 貴明, 毛塚 剛司, 西岡久 寿樹, 加藤 智啓, 竹内 大, 臼井 正彦
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 制御性樹状細胞を用いた実験的自己免疫性ぶどう膜網膜炎の抑制 (2007)
  • Author(s): 臼井 嘉彦, 竹内 大, 服部 貴明, 奥貫 陽子, 毛塚 剛司, 大井 桂子, 慶野 博, 臼井 正彦
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 角膜移植における補助刺激分子の発現 (2007)
  • Author(s): 服部 貴明, 臼井 嘉彦, 奥貫 陽子, 竹内 大, 熊倉 重人, 村松 隆次, 臼井 正彦
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 増殖糖尿病性網膜症におけるMonokine induced by interferon γ(Mig)(CXCL9)の発現 (2007)
  • Author(s): 若林 美宏, 臼井 嘉彦, 坪井 隆政, 箕田 宏, 奥貫 陽子, 毛塚 剛司, 竹内 大, 後藤 浩, 岩崎 琢也, 臼井 正
  • Organizer: 第111回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2007-04-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 前房出血を伴った急性前部ぶどう膜炎に樹氷状血管炎を合併した一例 (2006)
  • Author(s): 藤盛 圭太, 竹内 大, 臼井 正彦
  • Organizer: 第60回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 20061005-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ぶどう膜炎を伴うベーチェット病患者における抗α-enolase抗体の検討 (2006)
  • Author(s): 奥貫 陽子, 竹内 大, 毛塚 剛司, 後藤 浩, 臼井 正彦
  • Organizer: 第60回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 20061005-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 急性網膜壊死(桐沢型ぶどう膜炎)統計的解析 (2006)
  • Author(s): 臼井 嘉彦, 竹内 大, 後藤 浩, 毛塚 剛司, 箕田 宏, 藤盛 圭太, 坂井 潤一, 臼井 正彦
  • Organizer: 第60回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 20061005-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] HLA-A26陽性ベーチェット病患者と陰性患者の比較検討 (2006)
  • Author(s): 阿川 哲也, 山本 達郎, 坂本 俊哉, 森 秀樹, 竹内 大, 坂井 潤一, 臼井 正彦
  • Organizer: 第60回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 20061005-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ACAID類似のシステムにおけるCD8+調節性T細胞の解析(その1) (2006)
  • Author(s): 毛塚 剛司, 竹内 大, J.Wayne Streilein, 臼井 正彦
  • Organizer: スリーサム・イン米子 第40回日本眼炎症学会
  • Place of Presentation: 米子
  • Year and Date: 20060707-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ACAID類似のシステムにおけるCD8+調節性T細胞の解析(その2) (2006)
  • Author(s): 慶野 博, J.Wayne Streilein, J.Stein.Streilein, 臼井 正彦
  • Organizer: スリーサム・イン米子 第40回日本眼炎症学会
  • Place of Presentation: 米子
  • Year and Date: 20060707-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 実験的自己免疫性ぶどう膜網膜炎発症マウスの網膜、末梢血T細胞におけるケモカイン遺伝子の発現解析 (2006)
  • Author(s): 竹内 大, 臼井 嘉彦, 竹内 礼, 奥貫 陽子, 服部 貴明, 大井 桂子, 慶野 博, 毛塚 剛司, 臼井 正彦
  • Organizer: スリーサム・イン米子 第40回日本眼炎症学会
  • Place of Presentation: 米子
  • Year and Date: 20060707-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] アンギオテンシンII1型受容体拮抗薬による実験的自己免疫性ぶどう膜網膜炎の抑制 (2006)
  • Author(s): 奥貫 陽子, 臼井 嘉彦, 永井 紀博, 竹内 大, 毛塚 剛司, 服部 貴明, 石田 晋, 臼井 正彦
  • Organizer: スリーサム・イン米子 第40回日本眼炎症学会
  • Place of Presentation: 米子
  • Year and Date: 20060707-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 眼ベーチェット患者における補助シグナル分子の関与 (2006)
  • Author(s): 臼井 嘉彦, 竹内 大, 服部 貴明, 竹内 礼, 毛塚 剛司, 奥貫 陽子, 山川 直之, 秋葉 久弥, 臼井 正彦
  • Organizer: スリーサム・イン米子 第40回日本眼炎症学会
  • Place of Presentation: 米子
  • Year and Date: 20060707-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional Expression of B7H1 and B7DC on Retinal Pigment Epithelial Cells (2006)
  • Author(s): Y., Usui, Y., Okunuki, T., Hattori, T., Kezuka, H., Keino, N., Ebihara, S., Sugita, M., Usui, M., Takeuchi
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO) Fort Lauderdale
  • Place of Presentation: U.S.A
  • Year and Date: 20060530-0405
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Supplementation of Natural CD4+CD25+Regulatory T Cells Sufficiently Suppresses Experimental Autoimmune Uveoretinitis (2006)
  • Author(s): H., Keino, M., Takeuchi, Y., Usui, T., Hattori, P., Kezuka, M., Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO) Fort Lauderdale
  • Place of Presentation: U.S.A
  • Year and Date: 20060530-0405
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] OX40-OX40 Ligand Blockade Facilitate Long Term Corneal Allograft Survival (2006)
  • Author(s): T.Hattori, Y.Usui, Y.Sonoda, M.Takeuchi, M.Usui, H.Akiba, H.Yagita, K.Okumura
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)Fort Lauderdale
  • Place of Presentation: 米国
  • Year and Date: 20060430-0504
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Identification of Retinal Autoantigens in Behcet's Disease With Uveitis by Proteomic Approach (2006)
  • Author(s): Y.Okunuki, Y.Usui, T.Hattori, T.Kezuka, K.Nishioka, T.Kato, M.Takeuchi, M.Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)Fort Lauderdale
  • Place of Presentation: 米国
  • Year and Date: 20060430-0504
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Specific Chemokine Gene Expression in the Retina and T Cells Related to the Development of Experimental Autoimmune Uveoretinitis Compared With Other Immunized Mouse Models (2006)
  • Author(s): M.Takeuchi, A.Takeuchi, Y.Usui, T.Hattori, Y.Okunuki, K.Yoshida, M.Kuroda, M.Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)Fort Lauderdale
  • Place of Presentation: 米国
  • Year and Date: 20060430-0504
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Intravitreal Injection of Tacrolimus(FK506) Suppresses Experimental Autoimmune Uveoretinitis in Rats (2006)
  • Author(s): K-Ohi, H.Keino, N.Yamakawa, K.Murase, Y.Usui, T.Kezuka, M.Takeuchi, H.Goto, M.Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)Fort Lauderdale
  • Place of Presentation: 米国
  • Year and Date: 20060430-0504
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Neutrophil Apoptosis in Experimental Autoimmune Uveoretinitis (2006)
  • Author(s): J.Suzuki, K.Ohi, Y.Okunuki, Y.Usui, M.Takeuchi, M.Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)Fort Lauderdale
  • Place of Presentation: 米国
  • Year and Date: 20060430-0504
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Functional Expression of B7H1 and B7DC on Retinal Pigment Epithelial Cells (2006)
  • Author(s): Y.Usui, Y.Okunuki, T.Hattori, T.Kezuka, H.Keino, N.Abihara, S.Sugita, M.Usui, M.Takeuchi
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)Fort Lauderdale
  • Place of Presentation: 米国
  • Year and Date: 20060430-0504
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Supplementation of Natural CD4^+CD25^+ Regulatory T Cells Sufficiently Suppresses Experimental Autoimmune Uveoretinitis (2006)
  • Author(s): H.Keino, M.Takeucho, Y.Usui, T.Hattori, T.Kezuka, M.Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)Fort Lauderdale
  • Place of Presentation: 米国
  • Year and Date: 20060430-0504
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] OX40-OX40 Ligand Blockade Facilitate Long Term Corneal Allograft Survival (2006)
  • Author(s): T., Hattori, Y., Usui, Y., Sonoda, M., Takeuchi, M., Usui, H., Akiba, H., Yagita, K., Okumura
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO) Fort Lauderdale
  • Place of Presentation: U.S.A
  • Year and Date: 20060430-0504
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Identification of Retinal Autoantigens in Behcet's Disease With Uveitis by Proteomic Approach (2006)
  • Author(s): Y., Okunuki, Y., Usui, T., Hattori, T., Kezuka, K., Nishioka, T., Kato, M., Takeuchi, M., Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO) Fort Lauderdale
  • Place of Presentation: U.S.A
  • Year and Date: 20060430-0504
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Intravitreal Injection of Tacrolimus(FK506) Suppresses Experimental Autoimmune Uveoretinitis in Rats (2006)
  • Author(s): K., Oh-i, H., Keino, N., Yamakawa, K., Murase, Y., Usui, T., Kezuka, M., Takeuchi, H., Goto, M., Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO) Fort Lauderdale
  • Place of Presentation: U.S.A
  • Year and Date: 20060430-0504
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Neutropbil Apoptosis in Experimental Autoimmune Uveoretinitis (2006)
  • Author(s): J., Suzuki, K., Ohi, Y., Okunuki, Y., Usui, M., Takeuchi, M., Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO) Fort Lauderdale
  • Place of Presentation: U.S.A
  • Year and Date: 20060430-0504
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] CD25制御性T細胞のeye-derived toleranceへの関与 (2006)
  • Author(s): 慶野 博, 竹内 大, 毛塚 剛司, 服部 貴明, 田口 修, 臼井 正彦
  • Organizer: 第110回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20060413-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] タクロリムス(FK506)の硝子体腔内投与による実験的ぶどう膜炎抑制機序の解明 (2006)
  • Author(s): 大井 桂子, 慶野 博, 村瀬 耕平, 山川 直之, 毛塚 剛司, 竹内 大, 後藤 浩, 臼井 正彦
  • Organizer: 第110回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20060413-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ベーチェット病における網膜局在抗原のプオテオミクスによる網羅的解析 (2006)
  • Author(s): 奥貫 陽子, 臼井 嘉彦, 服部 貴明, 毛塚 剛司, 西岡久 寿樹, 加藤 智啓, 竹内 大, 臼井 正彦
  • Organizer: 第110回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20060413-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 網膜色素上皮細胞におけるB7H1とB7DCの発現とその機能 (2006)
  • Author(s): 臼井 嘉彦, 奥貫 陽子, 服部 貴明, 毛塚 剛司, 慶野 博, 海老原 伸行, 杉田 直, 竹内 大, 臼井 正彦
  • Organizer: 第110回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20060413-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 抗OX40 ligand抗体によるマウス角膜移植の拒絶抑制効果 (2006)
  • Author(s): 服部 貴明, 臼井 嘉彦, 園田 靖, 竹内 大, 奥貫 陽子, 臼井 正彦, 秋葉 久弥, 八木田 秀雄, 奥村 康
  • Organizer: 第110回日本眼科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20060413-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Specific Chemokine Gene Expression in the Retina and T Cells Related to the Development of Experimental Autoimmune Uveoretinitis Compared With Other Immunized Mouse Models (2006)
  • Author(s): M., Takeuchi, A., Takeuchi, Y., Usui, T., Hattori, Y., Okunuki, K., Yoshida, M., Kuroda, M., Usui
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO) Fort Lauderdale
  • Place of Presentation: U.S.A
  • Year and Date: 20060400
  • Description: 「研究成果報告書概要(欧文)」より