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2007 Fiscal Year Final Research Report Summary

Development of diagnostic tools and treatment based on the specific immune responses of VKH disease

Research Project

Project/Area Number 18591939
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionNippon Medical School

Principal Investigator

YAMAKI Kunhiko  Nippon Medical School, Opthalmolocgy, Associate professor (20125751)

Co-Investigator(Kenkyū-buntansha) 亀谷 修平  日本医科大学, 医学部, 講師 (30302269)
後藤 陽子  日本医科大学, 医学部, 講師 (80277524)
Project Period (FY) 2006 – 2007
KeywordsVKH disease / TCR / Antigen specific for / Speific immune response / dendritic cell
Research Abstract

To develop the reliable laboratory examination for diagnosis of VKH disease, we studied the T cell receptors (TCRs) specific for VKH disease. The antigens were raised against the TCR pools specific for VKH.
It was difficult to get the antibodies specific against TCRs from VKHdisease.
It was also difficult to establish human regulatory dendritic cell specific to antigens for VKH disease.
We studied the potential antigen presenting cells in intraocular tissues. There were several kind of cells that can uptake peptide antigens in intraocular tissues. These cells were divided into 3 to 4 groups.
These cell groups had different cell surface markers and may play different functions. In the choroidal tissues, these cells may function as APCs stimulating the T cells, while in the retina, these cells may function as APCs regulating the T cells/

  • Research Products

    (2 results)

All 2008 2007

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results)

  • [Journal Article] 眼内炎症反応の成立と抗原提示過程2008

    • Author(s)
      山木 邦比古
    • Journal Title

      日本医科大学医学会雑誌 4

      Pages: 8-14

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Presentation] Cytotoxity of TCLs and TCC from aqueous humors and/or CSF with acute and fresh stage of VKH disease2007

    • Author(s)
      Kunihiko Yamaki
    • Organizer
      5th International workshop on Vogt-Koyanagi-Harada disease and Sympathetic Ophthalmia
    • Place of Presentation
      Tokyo
    • Year and Date
      20070522-24
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2010-02-04  

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