Cellular biological study on the pathogenesis of glaucoma -approach from steroid glaucoma-

2008 Fiscal Year Final Research Report

• Project/Area Number: 18591945
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: University of Occupational and Environmental Health, Japan
• Principal Investigator: KUBOTA Toshiaki University of Occupational and Environmental Health, Japan, 医学部, 准教授 (30205140)
• Project Period (FY): 2006 – 2008
• Keywords: 緑内障

Research Abstract

緑内障は網膜神経節細胞がアポトーシスで減少し、最終的には失明する疾患で、日本の中途失明原因では第1位である。緑内障は原発性と続発性に分類される。ステロイドの点眼あるいは全身投与により反応性に眼圧が上昇し、続発緑内障が発症することがある。これをステロイド緑内障という。ステロイドによる眼圧上昇について臨床疫学的研究および組織学的研究を行い、ステロイド緑内障の発症メカニズムについて多くの問題点を明らかにした。

Research Products

• [Journal Article] Nipradilol and timolol induce forkhead transcription factor Foxo3a and peroxiredoxin 2 expression and protect trabecular meshwork cells from oxidative stress. (2009)
  • Author(s): Miyamoto N., Izumi H., Miyamoto R., Kubota T., Tawara A., Sasaguri Y., Kohno K.
  • Journal Title: Investigative Ophthalmology & Visual Science (in press) Pages: 0
  • Peer Reviewed
• [Journal Article] Trabecular meshwork in neovascular glaucoma eyes after the intravitreal injection of bevacizumab. (2009)
  • Author(s): Kubota T., Aoki R., Harada Y., Tou N., Kohno Y., Tawara A., Satoh H., Shimajiri S.
  • Journal Title: British Journal of Ophthalmology 93 Pages: 557-558
  • Peer Reviewed
• [Journal Article] Intravitreal injection of bevacizumab in the treatment of neovascular glaucoma. (2008)
  • Author(s): Kubota T., Aoki R., Harada Y., Tou N., Tawara A.
  • Journal Title: Japanese Journal of Ophthalmology 52 Pages: 410-412
  • Peer Reviewed
• [Journal Article] Influence of IOP measurement through the wrong eyepiece of the slit lamp on Goldmann applanation tonometry. (2008)
  • Author(s): Kubota T., Nagata T., Tawara A., Okada H., Ishibashi S., Yamashita M., Harada Y., Yanase M.
  • Journal Title: European Journal of Ophthalmology 18 Pages: 910-914
  • Peer Reviewed
• [Journal Article] One-year results of a multicenter controlled clinical trial of Triamcinolone in pars plana vitrectomy. (2008)
  • Author(s): Yamakiri K., Sakamoto T., Noda Y., Nakahara M., Ogino N., Kubota T., Yokoyama M., Furukawa M., Ishibashi T.
  • Journal Title: Graefe's Arch Clin Exp Ophthalmol 246 Pages: 959-966
  • Peer Reviewed
• [Journal Article] ステロイドレスポンダーの臨床的特徴 (2008)
  • Author(s): 小島亜有子、久保田敏昭、森田啓文、田原昭彦
  • Journal Title: 臨床眼科 62 Pages: 1519-1522
  • Peer Reviewed
• [Journal Article] The influence of central corneal thickness and corneal curvature radius on the intraocular pressure as measured by different tonometers; Non-contact and Goldmann applanation tonometers. (2008)
  • Author(s): Harada Y., Hirose H., Kubota T., Tawara A.
  • Journal Title: Journal of Glaucoma 17 Pages: 619-625
  • Peer Reviewed
• [Journal Article] Immunohistochemical evaluation of the extracellular matrix in trabecular meshwork in steroid-induced glaucoma. (2008)
  • Author(s): Tawara A., Tou N., Kubota T., Harada Y., Yokota K.
  • Journal Title: Graefe's Arch Clin Exp Ophthalmol 246 Pages: 1021-1028
  • Peer Reviewed
• [Journal Article] Direct inhibition of N-methyl-D-aspartate (NMDA) receptor function by antiglaucomatous β-antagonists. (2008)
  • Author(s): Nagata T., Ueno S., Morita H., Kubota T., Toyohira Y., Tsutsui M., Tawara A., Yanagihara N.
  • Journal Title: Journal of Pharmacolgical Sciences 106 Pages: 423-434
  • Peer Reviewed
• [Journal Article] Reduced incidence of intraoperative complications in a multicenter cotrolled clinical trial of Triamcinolone in vitrectomy. (2007)
  • Author(s): Yamakiri K., Sakamoto T., Noda Y., Nakahara M., Ogino N., Kubota T., Yokoyama M., Furukawa M., Sonoda Y., Yamada T., Doi N., Enaida H., Hata Y., Ishibashi T.
  • Journal Title: Ophthalmology 114 Pages: 289-296
  • Peer Reviewed
• [Journal Article] Effect of Latanoprost on the diurnal variations in the intraocular and ocular perfusion pressure in normal tension glaucoma. (2006)
  • Author(s): Ishibashi S., Hirose N., Tawara A., Kubota T.
  • Journal Title: Journal of Glaucoma 15 Pages: 354-357
  • Peer Reviewed
• [Journal Article] Ultrastructure of the trabecular meshwork in secondary glaucoma eyes after intravitreal triamcinolone acetonide. (2006)
  • Author(s): Kubota T., Okabe H., Hisatomi T., Yamakiri K., Sakamoto T., Tawara A.
  • Journal Title: Journal of Glaucoma 15 Pages: 117-119
  • Peer Reviewed
• [Presentation] Glaucoma Luncheon Seminar : Ocular hypertension induced by corticosteroid - clinical and histological studies. (2008)
  • Author(s): Kubota T.
  • Organizer: The first Joint Meeting of Korea-China-Japan Ophthalmologists
  • Place of Presentation: Seoul
  • Year and Date: 20081101-02
• [Presentation] Vascular endothelial cells are still present in trabecular meshwork of neovascular glaucoma eyes after intravitreal injection of bevacizumab. (2008)
  • Author(s): Kubota T.
  • Organizer: The first Joint Meeting of Korea-China-Japan Ophthlmologists
  • Place of Presentation: Seoul
  • Year and Date: 20081101-02
• [Presentation] Trabecular meshwork in neovascular glaucoma eyes after the intravitreal injection of bevacizumab. (2008)
  • Author(s): T. Kubota, R. Aoki, Y. Harada, N. Tou, Y. Kohno, A. Tawara, H. Satoh, S. Shimajiri
  • Organizer: World Ophthalmology Congress
  • Place of Presentation: Hong Kong
  • Year and Date: 20080628-0702
• [Presentation] 血管新生緑内障に対するベバシズマブ硝子体内注入の組織学的検索 (2008)
  • Author(s): 久保田敏昭、青木瑠美、原田行規、藤紀彦、向野由賀利、田原昭彦、佐藤斉、島尻正平
  • Organizer: 第112回日本眼科学会総会
  • Place of Presentation: 横浜市
  • Year and Date: 20080417-20
• [Presentation] シンポジウム ; ステロイド治療のアップデート 新しい投与方法と副作用 ステロイド薬による眼圧上昇 (2007)
  • Author(s): 久保田敏昭
  • Organizer: 第61回日本臨床眼科学会
  • Place of Presentation: 京都市
  • Year and Date: 20071011-14
• [Presentation] Clinical and histological study of ocular hypertension induced by corticosteroid. (2007)
  • Author(s): Kubota T.
  • Organizer: Symposium III : Secondary glaucoma The 2^<nd> Annual Meeting of the Glaucoma Summer Camp
  • Place of Presentation: Awajishima
  • Year and Date: 20070802-03
• [Presentation] Influence of uncorrected eyepiece measuring on the intraocular pressure reading using goldmann applanation tonometer. (2007)
  • Author(s): Kubota T., Nagata T., Tawara A., Okada H., Ishibashi S., Yamashita M., Harada Y., Yanase M.
  • Organizer: Joint Congress of SOE/AAO 2007
  • Place of Presentation: Vienna, Austria
  • Year and Date: 20070609-12
• [Presentation] 基調講演 : 先天異常-緑内障の観点から (2007)
  • Author(s): 久保田敏昭
  • Organizer: 第77回九州眼科学会
  • Place of Presentation: 宮崎市
  • Year and Date: 20070511-13
• [Presentation] トリアムシノロン併用硝子体手術1年後の眼圧と合併症 : 多施設無作為前向き調査結果 (2007)
  • Author(s): 山切啓太、坂本泰二、荻野誠周、古川真理子、熊谷和之、横山光伸、久保田敏昭、中原正彰
  • Organizer: 第30回日本眼科手術学会
  • Place of Presentation: 京都市
  • Year and Date: 20070126-28
• [Presentation] The influence of central corneal thickness and corneal curvature on intraocular pressure measured by different tonometers ; non-contact and Goldmann applanation tonometers. (2006)
  • Author(s): Harada Y., Hirose N., Kubota T., Tawara A.
  • Organizer: 2006 ARVO
  • Place of Presentation: Fort Laudardale, U.S.A.
  • Year and Date: 20060430-0504
• [Presentation] 房水流出路の形態変化と緑内障の発症 -ステロイド緑内障からのアプローチ- (2006)
  • Author(s): 久保田敏昭
  • Organizer: シンポジウム2 : 緑内障の病態解明と治療の展望、第110回日本眼科学会総会
  • Place of Presentation: 大阪市
  • Year and Date: 20060413-16