2009 Fiscal Year Final Research Report
Time-dependent change for adhesion molecules appearance of migrated epidermal cell during wound healing
| Project/Area Number |
18591975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
MORIGUCHI Takahiko Kawasaki Medical School, 医療技術学部, 教授 (10111816)
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| Co-Investigator(Kenkyū-buntansha) |
OKA Hiroaki 川崎医科大学, 医学部, 准教授 (40152277)
URUSHIHARA Katsuyuki 川崎医科大学, 医学部, 講師 (00278938)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 急性創傷 / 慢性創傷 / 創傷治癒 / 褥瘡 / 下腿潰瘍 / インテグリン / ラミニン / フィブロネクチン |
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| Research Abstract |
In acute wound edge, the relation with (1) area of increase of α5β1 and fibronectin, (2) area of α5β1 positive and laminin negative, (3) increasing area of fibronectin and laminin negative, were significant correlated. In chronic wound edge, the relation with (1) area of α5β1 positive and increase fibronectin, (2) area of α5β1 positive and laminin negative, (3) area of increase fibronectin and epidermal elongation, (4) epidermal elongation and epidermal hypertrophy, were significant correlated.
In acute wound, α5β1, fibronectin are related with migrated epidermal cell. In chronic wound, they are lack. In conclusion, re-epithelization will be promoted by culture skin with some type of integrin in chronic wound.
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