2007 Fiscal Year Final Research Report Summary
Neuronal Mechanisms of Cerebral Cortex Controlling Trigeminal Mesencephalic Spindle Atfetents for Smooth Mastication
| Project/Area Number |
18592000
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YOSHIDA Atsushi Osaka University, Grad. School of Dentistry, Professor (90201855)
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| Co-Investigator(Kenkyū-buntansha) |
MORITANI Masayuki Osaka University, Grad. School of Dentistry, Assistant Professor (80303981)
INOUE Tomio Osaka University, Grad. School ofDenlistry, Professor (70184760)
ONO Takahiro Osaka University, Grad. School of Dentistry, Associate Professor (30204241)
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| Project Period (FY) |
2006 – 2007
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| Keywords | brain / neuroscience / anatomy / dentistry / jaw movement / cortex |
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| Research Abstract |
In subprimates, projections from the cerebral cortex to the trigeminal motor nucleus (Vmo) are considered to be not direct, but indirect through premotoneurons in the brainstem. However, the projection patterns of the corticofugal direct projections to the premotoneurons have not been examined well. Whereas, the premotoneurons for the Vmo include the mesencephalic nucleus (Vmes) neurons that are primary afferents whose cell bodies are located in the brain. Therefore the present study was conducted to examine the projection patterns morphologically in the rat. At first, we examined the distribution of the premotoneurons for the Vmo by making an injection of a retrograde tracer into the Vmo. The premotoneurons were found in the Vmes ipsilateral to the injection site, and in the trigeminal oral and principal nucleus, parabrachial nucleus, supratrigeminal nucleus, parvocellular reticular formation (pRF) surrounding the Vmo, and pRF medial to the trigeminal sensory nuclei bilaterally with an ipsilateral predominance to the injection site. Then, we examined the distribution of cortical neurons projecting directly to the premotoneurons for the Vmo, by making an injection of the retrograde tracer into the brainstem where the premotoneurons were labeled in the first experiment. The cortical neurons projecting to the reticular formation around the Vmo, the trigeminal oral nucleus, and the Vmes nucleus were found in the primary and secondary motor cortex, the primary somatosensory cortex, and the insular and limbic cortex, respectively.
The present study demonstrated several, strong projections from the distinct cortical areas to the Vmo through premotoneurons including the Vmes neurons, which are topographically organized. The present study contributed to reveal complex neuronal mechanisms in the cortical control of jaw movements.
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Research Products
(46 results)
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[Journal Article] The somatotopic organization of trigeminal premotoneurons in the cat brainstem2007
Author(s)
Yamamoto, M., Moritani, M., Chang, Z., Taki, I., Tomita, A., Ono, T., Bae, Y C., Shigenaga, Y., Yoshida, A
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Journal Title
Brain Res 1149
Pages: 111-117
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Developmental changes in distribution of y-aminobutyric acid-and glycine-immunoreactive boutons on rat trigeminal motoneurons. I. Jaw-closing motoneurons2007
Author(s)
Paik, S K., Bae, J Y., Park, S E., Moritani, M., Yoshida, A., Yeo, E J., Choi, K S., Ahn, D K., Moon, C., Shigenaga, Y., Bae, Y C
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Journal Title
J. Comp. Neurol 503
Pages: 779-789
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Developmental changes in distribution of GABA-and glycine-immunoreactive boutons on rat trigeminal motoneurons-II. Jaw opening motoneurons2007
Author(s)
Yeo, E., Bae, J., Paik, S., Cho, Y., Yi, H., Masayuki, M., Atsuhi, Y., Kim, Y., Moon, C., Bae, Y
Organizer
Society of Neuroscience Annual Meeting
Place of Presentation
San Diego Convention Center, San Diego, USA
Year and Date
20071103-07
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 下顎運動の神経制御メカニズム2007
Author(s)
中村史朗 等
Organizer
第49回歯科基礎医学会学術大会ならびに総会
Place of Presentation
北海道大学(札幌市)
Year and Date
20070829-31
Description
「研究成果報告書概要(和文)」より
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[Presentation] Size analysis of axon and somata of neurons innervating dental pulp in the rat trigeminal ganglion2006
Author(s)
Paik, S K., Kim, Y J., Park, K P., Shin, H S., Kim, Y K., Bae, J Y., Yeo, E J., Kim, Y S., Yoon, S M., Moritani, M., Yoshida, A., Shigenaga, Y., Moon, C., Bae, Y C
Organizer
Society of Neuroscience Annual Meeting
Place of Presentation
Georgia World Congress Center, Atlanta, USA
Year and Date
20061013-18
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Brain neural circuitry related to jaw movements. I. A disynaptic pathway between cortex and trigeminal motor nucleus2006
Author(s)
Chang, Z., Moritani, M., Yamamoto, M., Ono, T., Bae, Y C., Shigenaga, Y., Yoshida, A
Organizer
Society of Neuroscience Annual Meeting
Place of Presentation
Georgia World Congress Center, Atlanta, USA
Year and Date
20061013-18
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Morphologic and functional properties of oralis neurons innervating bilateral trigeminal motor nuclei2006
Author(s)
Yamamoto, M., Yoshida, A., Moritani, M., Chang, Z., Ono, T., Bae, Y C., Shigenaga, Y
Organizer
International Mastication Symposium
Place of Presentation
Brisbane, Australia
Year and Date
20060600
Description
「研究成果報告書概要(欧文)」より
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[Book] Encyclopedia of Pain2006
Author(s)
Shigenaga Y., and Yoshida, A
Total Pages
2536-2541
Publisher
Springer Berlin Heidelberg
Description
「研究成果報告書概要(和文)」より
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