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2007 Fiscal Year Final Research Report Summary

Neuronal Mechanisms of Cerebral Cortex Controlling Trigeminal Mesencephalic Spindle Atfetents for Smooth Mastication

Research Project

Project/Area Number 18592000
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionOsaka University

Principal Investigator

YOSHIDA Atsushi  Osaka University, Grad. School of Dentistry, Professor (90201855)

Co-Investigator(Kenkyū-buntansha) MORITANI Masayuki  Osaka University, Grad. School of Dentistry, Assistant Professor (80303981)
INOUE Tomio  Osaka University, Grad. School ofDenlistry, Professor (70184760)
ONO Takahiro  Osaka University, Grad. School of Dentistry, Associate Professor (30204241)
Project Period (FY) 2006 – 2007
Keywordsbrain / neuroscience / anatomy / dentistry / jaw movement / cortex
Research Abstract

In subprimates, projections from the cerebral cortex to the trigeminal motor nucleus (Vmo) are considered to be not direct, but indirect through premotoneurons in the brainstem. However, the projection patterns of the corticofugal direct projections to the premotoneurons have not been examined well. Whereas, the premotoneurons for the Vmo include the mesencephalic nucleus (Vmes) neurons that are primary afferents whose cell bodies are located in the brain. Therefore the present study was conducted to examine the projection patterns morphologically in the rat. At first, we examined the distribution of the premotoneurons for the Vmo by making an injection of a retrograde tracer into the Vmo. The premotoneurons were found in the Vmes ipsilateral to the injection site, and in the trigeminal oral and principal nucleus, parabrachial nucleus, supratrigeminal nucleus, parvocellular reticular formation (pRF) surrounding the Vmo, and pRF medial to the trigeminal sensory nuclei bilaterally with an ipsilateral predominance to the injection site. Then, we examined the distribution of cortical neurons projecting directly to the premotoneurons for the Vmo, by making an injection of the retrograde tracer into the brainstem where the premotoneurons were labeled in the first experiment. The cortical neurons projecting to the reticular formation around the Vmo, the trigeminal oral nucleus, and the Vmes nucleus were found in the primary and secondary motor cortex, the primary somatosensory cortex, and the insular and limbic cortex, respectively.
The present study demonstrated several, strong projections from the distinct cortical areas to the Vmo through premotoneurons including the Vmes neurons, which are topographically organized. The present study contributed to reveal complex neuronal mechanisms in the cortical control of jaw movements.

  • Research Products

    (46 results)

All 2008 2007 2006 Other

All Journal Article (16 results) (of which Peer Reviewed: 9 results) Presentation (27 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Expression of P2X3 receptor in the trigeminal sensory nuclei of the rat2008

    • Author(s)
      Kim YS, et. al.
    • Journal Title

      J Comp Neurol 506

      Pages: 627-639

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] GABA-and glycine-like immunoreactivity in axonal endings presynaptic to the vibrissa afferents in the cat trigeminal interpolar nucleus2008

    • Author(s)
      Moon YS, et. al.
    • Journal Title

      Neuroscience 152

      Pages: 138-145

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Spatial distribution patterns of excitatory and inhibitory synapses in the dendritic tree differ between jaw-closing and -opening motoneurons2007

    • Author(s)
      Shigenaga Y, et. al.
    • Journal Title

      Archives Oral Biol. 52

      Pages: 321-324

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Nociceptive craniofacial muscle primary afferent neurons synapse in both the rostral and caudal brain stem2007

    • Author(s)
      Dessem D, et. al.
    • Journal Title

      J Neurophysiol 98

      Pages: 64-68

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Influence of human jaw movement on cerebral blood flow2007

    • Author(s)
      Hasegawa Y, et. al.
    • Journal Title

      J. Dent. Res 86

      Pages: 321-324

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Task-induced activation and hemispheric dominance in cerebral circulation during gum chewing.2007

    • Author(s)
      Ono T, et. al.
    • Journal Title

      J. Neurol. 254

      Pages: 1427-1432

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] The somatotopic organization of trigeminal premotoneurons in the cat brainstem2007

    • Author(s)
      Yamamoto M, et. al.
    • Journal Title

      Brain Res 1149

      Pages: 111-117

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Developmental changes in distribution of r-aminobutyric acid-and glycine-immunoreactive boutons on rat trigeminal motoneurons. I. Jaw-closing motoneurons.2007

    • Author(s)
      Paik SK, et. al.
    • Journal Title

      J Comp Neurol 503

      Pages: 779-789

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Spatial distribution patterns of excitatory and inhibitory synapses in the dendritic tree differ between jaw-closing and -opening motoneurons2007

    • Author(s)
      Shigenaga, Y., Bae, Y C., Moritani, M., Yoshida, A
    • Journal Title

      Archives Oral Biol 52

      Pages: 321-324

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Nociceptive craniofacial muscle primary afferent neurons synapse in both the rostral and caudal brain stem2007

    • Author(s)
      Dessem, D., Moritani, M., Ambalavanar, R
    • Journal Title

      J. Neurophysiol 98

      Pages: 214-223

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Influence of human jaw movement on cerebral blood flow2007

    • Author(s)
      Hasegawa, Y., Ono, T., Hori, K, Nokubi, T
    • Journal Title

      J. Dent. Res 86

      Pages: 64-68

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Task-induced activation and hemispheric dominance in cerebral circulation during gum chewing2007

    • Author(s)
      Ono, T., Hasegawa, Y., Hori, K., Nokubi, T., Hamasaki, T
    • Journal Title

      J. Neurol 254

      Pages: 1427-1432

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The somatotopic organization of trigeminal premotoneurons in the cat brainstem2007

    • Author(s)
      Yamamoto, M., Moritani, M., Chang, Z., Taki, I., Tomita, A., Ono, T., Bae, Y C., Shigenaga, Y., Yoshida, A
    • Journal Title

      Brain Res 1149

      Pages: 111-117

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Developmental changes in distribution of y-aminobutyric acid-and glycine-immunoreactive boutons on rat trigeminal motoneurons. I. Jaw-closing motoneurons2007

    • Author(s)
      Paik, S K., Bae, J Y., Park, S E., Moritani, M., Yoshida, A., Yeo, E J., Choi, K S., Ahn, D K., Moon, C., Shigenaga, Y., Bae, Y C
    • Journal Title

      J. Comp. Neurol 503

      Pages: 779-789

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Coordination of tongue pressure and jaw movement in mastication2006

    • Author(s)
      Hori K, et. al.
    • Journal Title

      J. Dent. Res. 85

      Pages: 187-191

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Coordination of tongue pressure and jaw movement in mastication2006

    • Author(s)
      Hori, K., Ono, T., Nokubi, T
    • Journal Title

      J. Dent. Res 85

      Pages: 187-191

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Neuronal mechanisms controlling jaw movement2008

    • Author(s)
      Yoshida, A
    • Organizer
      21st Century COE Program Symposium, Organization of Frontier Bio Dentistry Network Japan-Korea International Symposium
    • Place of Presentation
      20080201-02
    • Year and Date
      20080201-02
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] A disynaptic patbway between cortex and trigeminal motor nucleus.2007

    • Author(s)
      Chang Z, et. al.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego, US
    • Year and Date
      20071103-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Developmental changes in distribution of GABA-and glycine-immunoreactive boutons on rat trigeminal motoneurons-II. Jaw opening motoneurons.2007

    • Author(s)
      Yeo E, et. al.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      San Diego, US
    • Year and Date
      20071103-07
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Developmental changes in distribution of GABA-and glycine-immunoreactive boutons on rat trigeminal motoneurons-II. Jaw opening motoneurons2007

    • Author(s)
      Yeo, E., Bae, J., Paik, S., Cho, Y., Yi, H., Masayuki, M., Atsuhi, Y., Kim, Y., Moon, C., Bae, Y
    • Organizer
      Society of Neuroscience Annual Meeting
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      20071103-07
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 下顎運動の神経制御メカニズム2007

    • Author(s)
      中村史朗 等
    • Organizer
      第49回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      20070829-31
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 大脳皮質から三叉神経運動核への投射の様態2007

    • Author(s)
      吉田篤, 等
    • Organizer
      第49回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      20070829-31
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] モルモットの大脳皮質顎顔面口腔運動領域と視床との神経連絡2007

    • Author(s)
      磯貝文彦, 等
    • Organizer
      第49回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      20070829-31
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 大脳皮質ニューロンはいかにして顎運動を制御するのか神経トレーサーを用いたラットでの投射の解析2007

    • Author(s)
      富田章子 等
    • Organizer
      日本咀嚼学会 第18回学術大会
    • Place of Presentation
      吹田市
    • Year and Date
      20070825-26
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 開口筋運動核および閉口筋運動核に投射する運動前ニューロンの分布の特徴2007

    • Author(s)
      山本雅章 等
    • Organizer
      日本補綴歯科学会
    • Place of Presentation
      神戸
    • Year and Date
      20070518-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 臨床に役立つ歯と口の中枢神経支配、歯科臨床医リフレッシュセミナー2007

    • Author(s)
      吉田篤.
    • Organizer
      日本口腔外科学会
    • Place of Presentation
      池田市 大阪
    • Year and Date
      2007-06-16
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 三叉神経感覚核に投射する大脳皮質ニューロンの分布とその投射様態2007

    • Author(s)
      常征 等
    • Organizer
      第112回日本解剖学会総会・全国学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2007-03-29
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Size analysis of axon and somata of neurons innervating dental pulp in the rat trigeminal ganglion2006

    • Author(s)
      Paik SK, et. al.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20061013-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Expression of P2X3 receptor in the trigeminal sensory nuclei of the rat2006

    • Author(s)
      Moon C, et. al.
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      20061013-18
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Size analysis of axon and somata of neurons innervating dental pulp in the rat trigeminal ganglion2006

    • Author(s)
      Paik, S K., Kim, Y J., Park, K P., Shin, H S., Kim, Y K., Bae, J Y., Yeo, E J., Kim, Y S., Yoon, S M., Moritani, M., Yoshida, A., Shigenaga, Y., Moon, C., Bae, Y C
    • Organizer
      Society of Neuroscience Annual Meeting
    • Place of Presentation
      Georgia World Congress Center, Atlanta, USA
    • Year and Date
      20061013-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Brain neural circuitry related to jaw movements. I. A disynaptic pathway between cortex and trigeminal motor nucleus2006

    • Author(s)
      Chang, Z., Moritani, M., Yamamoto, M., Ono, T., Bae, Y C., Shigenaga, Y., Yoshida, A
    • Organizer
      Society of Neuroscience Annual Meeting
    • Place of Presentation
      Georgia World Congress Center, Atlanta, USA
    • Year and Date
      20061013-18
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 咬筋感覚を伝達する三叉神経節ニューロンのP2×_3発現2006

    • Author(s)
      森谷正之 等
    • Organizer
      第48回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      鶴見大学(横浜市)
    • Year and Date
      20060921-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 大脳皮質から三叉神経感覚核への投射の様態の検討2006

    • Author(s)
      常征 等
    • Organizer
      第48回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      鶴見大学(横浜市)
    • Year and Date
      20060921-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] モルモット大脳皮質咀嚼野における刺激部位と誘発顎運動の関係2006

    • Author(s)
      藤本正一郎 等
    • Organizer
      第48回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      鶴見大学(横浜市)
    • Year and Date
      20060921-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 三叉神経上核に存在するpromotor nguronの生理学的および彩態学的特性2006

    • Author(s)
      中村史朗 等
    • Organizer
      第48回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      鶴見大学(横浜市)
    • Year and Date
      20060921-23
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Corticofugal pathway to the trigeminal motor nucleus through premotoneuron in the trigeminal oral nucleus.2006

    • Author(s)
      Chang Z, et. al.
    • Organizer
      The 29th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      国立京都国際会議場(京都市)
    • Year and Date
      20060719-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] The distribution of excitatory and inhibitory synapses on single, reconstructed trigemianl motoneurons in the cat2006

    • Author(s)
      Shigenaga, Y, et. al.
    • Organizer
      International Mastication Symposium
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      20060600
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Morphologic and functional properties of oralis neurons innervating bilateral trieeminal motor nuclei2006

    • Author(s)
      Yamamoto, M, et. al.
    • Organizer
      International Mastication Symposium
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      20060600
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] The distribution of excitatory and inhibitory synapses on single, reconstructed trigeminal motoneurons in the cat2006

    • Author(s)
      Shigenaga, Y., Bae, Y C., Moritani, M., Yoshida, A
    • Organizer
      International Mastication Symposium
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      20060600
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Morphologic and functional properties of oralis neurons innervating bilateral trigeminal motor nuclei2006

    • Author(s)
      Yamamoto, M., Yoshida, A., Moritani, M., Chang, Z., Ono, T., Bae, Y C., Shigenaga, Y
    • Organizer
      International Mastication Symposium
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      20060600
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] ラット三叉神経節に存在する咬筋感覚伝達ニューロンにおけるP2X_3受容体発現2006

    • Author(s)
      森谷正之 等.
    • Organizer
      第111回日本解剖学会全国学術集会
    • Place of Presentation
      北里大学医学部
    • Year and Date
      20060329-31
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 三叉神経吻側核ニューロンの三叉神経運動核への両側投射に関する形態学的ならびに生理学的研究2006

    • Author(s)
      山本雅章 等.
    • Organizer
      第111回日本解剖学会全国学術集会
    • Place of Presentation
      北里大学医学部
    • Year and Date
      20060329-31
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 閉口筋運動核および開口筋運動核へ投射する運動前ニューロンの分布の相違2006

    • Author(s)
      山本雅章 等
    • Organizer
      第82回日本解剖学会近畿地区学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2006-11-25
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 生命歯科医学のカッティング・エッジ2008

    • Author(s)
      吉田篤, 等
    • Total Pages
      144-156
    • Publisher
      大阪大学出版会
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Encyclopedia of Pain2006

    • Author(s)
      Shigenaga Y., and Yoshida, A
    • Total Pages
      2536-2541
    • Publisher
      Springer Berlin Heidelberg
    • Description
      「研究成果報告書概要(和文)」より
  • [Remarks] 「研究成果報告書概要(和文)」より

    • URL

      http://www.dent.osaka-u.ac.jp/~anat2/

URL: 

Published: 2010-02-04  

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