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2007 Fiscal Year Final Research Report Summary

Study on the role of the primary afferent fibers in thedevelopment/maintenance of the intractable pain in the oro-facial region

Research Project

Project/Area Number 18592030
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionOhu University

Principal Investigator

YONEHARA Norifumi  Ohu University, School of Pharmaceutical Sciences, Professor (70124534)

Co-Investigator(Kenkyū-buntansha) TAKEMURA Motohide  Osaka University, Faculty of Dentistry, Associate professor (70192169)
SHINICHI Sugiyo  Osaka University, Faculty of Dentistry, Assistant professor (90397688)
KOIKE Yuuichi  Ohu University, School of Pharmaceutical Sciences, Professor (90109421)
TAKADA Yoshinobu  Ohu University, School of Pharmaceutical Sciences, Professor (40119590)
ABE Kenji  Ohu University, School of Pharmaceutical Sciences, Assistant Professor (60405991)
Project Period (FY) 2006 – 2007
KeywordsGlutamate / Nitric oxide / Peripheral nerve injury / Microdialysis / Trigeminal nucleus caudalis / Allodynia / Nerve injury
Research Abstract

It is well known that the pathological pain states such as allodynia, hyperalgesia, and phantom pain can result after nerve injury or chronic inflammation. It is also recognized that an increase in the afferent impulse flow from damaged nerve areas enhances the activity of spinal dorsal horn neurons and produces pain. The activation of N-methyl-D-aspartate (NMDA) receptors in spinal dorsal horn neurons is widely regarded to be critical for the development and maintenance of the hyperalgesia induced by nerve injury.
Increasing evidence suggests that, at the site of the first synaptic relay of nociceptive pathway, activation of N-methyl-D-aspartate (NMDA) receptors modulates nociceptive transmission via a nitric oxide (NO) pathway. Therefore, to further clarify the central mechanisms underlying the peripheral nerve injury-induced pathological pain in the trigeminal system, this project examined influence of NO to the change in excitatory amino acids (EAAs) level in the superficial layer of subnucleus caudalis of the brain-stem trigeminal sensory nuclear complex (SpVc-I, II) following a ligation injury to the inferior alveolar nerves.
A very high EAAs release responses was observed immediately after the start of the perfusion in ligated animals compared with sham-operated rats. The EAA level evoked by application of the 40-V tooth pulp-stimulation or 1% capsaicin cream was significantly higher in the ligated animals than those in the sham-operated animals. This increase of EAAs level induced by capsaicin cream was inhibited by adding carboxy-PTIO, an NO scavenger, to the perfusate.
These results suggest that alterations in the stimulus-evoked raised EAA levels that occur in the site of the first synaptic relay of the dental pain pathway and which are expressed via endogenous NO, and which play an important role in development and/or maintenance of pathological pain states following dental peripheral nerve injury

  • Research Products

    (8 results)

All 2008 2007 2006

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (1 results) Book (1 results)

  • [Journal Article] 痛みとグルタミン酸受容体2007

    • Author(s)
      米原典史, 八巻史子
    • Journal Title

      麻酔、56増刊

      Pages: S129-S140

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Alteration of sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain2006

    • Author(s)
      Yoshimura M.and Yonehara N.
    • Journal Title

      Neuroscience Res 56

      Pages: 21-28

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Effect of morphine on the release of excitatory amino acids in the rat hind instep: Pain is modulated by the interactionbetween the peripheral opioid and glutamate systems2006

    • Author(s)
      Jin Y-H., Nishioka H., Wakabayashi K., Fujita T.and Yonehara N.
    • Journal Title

      Neuroscience 138

      Pages: 1329-1339

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Trigeminal neuronal activation and projection to intralaminar thalamic nuclei after orofacial inflammation2006

    • Author(s)
      Sugiyo S., Takemura M., Dubner R. and Ren K.
    • Journal Title

      Brain Res 1097

      Pages: 116-122

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Alteration of sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain2006

    • Author(s)
      Yoshimura, M., Yonehara, N
    • Journal Title

      Neuroscience Res 56

      Pages: 21-28

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effect of morphine on the release of excitatory amino acids in the rat hind instep : Pain is modulated by the interactionbetween the peripheral opioid and glutamate systems2006

    • Author(s)
      Jin, Y-H., Nishioka, H., Wakabayashi, K., Fujita, T., Yonehara, N
    • Journal Title

      Neuroscience 138

      Pages: 1329-1339

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] グルタミン酸受容体と疼痛2007

    • Author(s)
      米原 典史
    • Organizer
      日本麻酔学会第54回学術集会
    • Place of Presentation
      札幌
    • Year and Date
      20070531-0602
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 口腔顔面の痛みのトピックス:生命歯科医学のカッティング、エッジ2008

    • Author(s)
      竹村 元秀、杉生 真一
    • Publisher
      大阪大学出版会(印刷中)
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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