2007 Fiscal Year Final Research Report Summary
Clarification of mechanisms of analgesia and immobility induced by general anesthesia, and exploration of new anesthetic methods
| Project/Area Number |
18592037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
IRIFUNE Masahiro Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor (10176521)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Michio Hiroshima University, Graduate School of Biomedical Sciences, Professor (30034094)
DOHI Toshihiro Hiroshima University, Graduate School of Biomedical Sciences, Professor (00034182)
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| Project Period (FY) |
2006 – 2007
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| Keywords | General Anesthesia / Behavioral pharmacology / μ-Opioid receptor agonist / α_2-Adrenergic receptor agonist / Glycine transporter inhibitor / Unconsciousness / Immobility / Analgesia |
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| Research Abstract |
The role of μ-opioid, α_2-adrenergic, and glycine receptors in general anesthetic action was examined in mice. All drugs were administered intraperitoneally. General anesthetic action was evaluated using three end points: 1) loss of righting reflex (LORR; as a measure of unconsciousness), 2) loss of movement in response to noxious stimulation (as a measure of immobility), and 3) loss of nociceptive response (as a measure of analgesia). Gabaculine, which is a γ-aminobutyric acid (GABA)-transaminase inhibitor that increases endogenous GABA in the brain, dose-dependently induced LORR. However, even a large dose produced no immobility. Both the μ-opioid receptor agonist morphine and the α_2-adrenergic receptor agonist dexmedetomidine dose-dependently induced analgesia. In addition, both morphine and dexmedetomidine in combination with gabaculine produced immobility in a dose-dependent fashion. However, glycine transporter inhibitors did not affect immobility. These findings suggest that LORR is associated with enhanced GABA activity, and immobility is involved in μ-opioid and α_2-adrenergic receptors, but not glycine receptors.
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[Journal Article] Riluzole, a glutamate release inhibitor, induces loss of righting reflex, antinociception, and immobility in response to noxious stimulation in mice2007
Author(s)
Irifune, M., Kikuchi, N., Saida, T., Takarada, T., Shimizu, Y., Endo, C., Morita, K., Dohi, T., Sato, T., Kawahara, M
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Journal Title
Anesth Analg 104(6)
Pages: 1415-21
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Increased gamma-aminobutyric acid levels in mouse brain induce loss of righting reflex, but not immobility, in response to noxious stimulation2007
Author(s)
Katayama, S., Irifune, M., Kikuchi, N., Takarada, T., Shimizu, Y., Endo, C., Takata, T., Debi, T., Sato, T., Kawahara, M
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Journal Title
Anesth Analg 104(6)
Pages: 104(6)
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] MK-801 enhances gabaculine-induced loss of the righting reflex in mice, but not immobility2007
Author(s)
Irifune, M., Katayama, S., Takarada, T., Shimizu, Y., Endo, C., Takata, T., Morita, K., Dohi, T., Sato, T., Kawahara, M
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Journal Title
Can J Anaesth 54(12)
Pages: 998-1005
Description
「研究成果報告書概要(欧文)」より
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