2007 Fiscal Year Final Research Report Summary
A genetic mode of regulation for the growth correlation of mandible and craniomaxilla
| Project/Area Number |
18592058
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
SAKAMOTO Maya Tohoku University, Tohoku University, Tohoku University Hospital, Lecture (90157686)
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| Co-Investigator(Kenkyū-buntansha) |
IIKUBO Masahiro Tohoku University, Graduate School of Dentistry, Lecture (80302157)
MORI Shiro Tohoku University, Tohoku University Hospital, Lecture (80230069)
SASANO Takashi Tohoku University, Graduate School of Dentistry, Professor (10125560)
SHOJI Noriaki Tohoku University, Tohoku University Hospital, Lecture (70250800)
ONO Masao Tohoku University, Graduate School of Medi, cine, Professor (20302218)
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| Project Period (FY) |
2006 – 2007
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| Keywords | mandibular size / mandibular shape / craniomaxillary development / linkage analysis / QTL analysis |
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| Research Abstract |
A growth correlation of mandible and craniomaxilla is essential for the inheritance of morphology, behavior, and cranial function of a species. The aim of this study is to demonstrate a genetic mode of regulation for the growth correlation of mandible and craniomaxilla. To identify a genetic link of the correlation, we analyzed genetically varied intercross F2 mice, which were generated from two different strains of mice, MRL/Mp.Faslpr-rpl/rpl (MRL/rpl) and C3H/HeJ.Faslpr (C3H/lpr). Morphological measurements for mandible and craniomaxilla were performed at 20 weeks of age for all mice. A genome-wide genetic analysis for the morphological indexes of mandible and craniomaxilla was performed using 247 F2 intercross mice at 96 microsattelite loci. The results are summarized as follows: 1. The indexes of mandibular width were highly, significantly different between male and female mice. 2. The morphological variation of maxillo-mandibular region (MMR) was significantly associated with several genetic loci, which were located in the vicinity of D1Mit46 (chr. 1), D10Mitl64 (chr. 10), and D11Mit263 (chr. 11). 3. The morphological variation of MMR was largely dependent on those in mandibular width. 4. As positional candidates associated with the chr. 1 locus, the genes encoding insulin-like growth-factor-binding proteins (IGFBP2 and 5) were pointed out.
In conclusion, the mouse model indicates that the morphology of MMR is controlled under the polygenic mode of inheritance. Presently, either of IGFBP2 or 5 was suggested to be a positional candidate for a genetic factor that affects the morphology of MMR.
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